Reactome | p-S303,307-HSF1 [cytosol]

p-S303,307-HSF1 [cytosol]

Stable Identifier

R-HSA-4793922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S303,307-Heat shock transcription factor 1, HSTF 1, Heat shock factor protein 1

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q00613 HSF1

Gene Names

HSF1, HSTF1

Chain

chain:1-529

Reference Genes

BioGPS Gene:3297 HSF1

COSMIC (genes):HSF1 HSF1

CTD Gene:3297 HSF1

dbSNP Gene:3297 HSF1

ENSEMBL:ENSG00000185122 HSF1

ENSEMBL:ENSG00000284774 HSF1

HGNC:5224 HSF1

KEGG Gene (Homo sapiens):3297 HSF1

Monarch:3297 HSF1

NCBI Gene:3297 HSF1

OMIM:140580 HSF1

UCSC:Q00613 HSF1

Reference Transcript

Other Identifiers

0005220722

11723695_s_at

17073759

202344_at

213756_s_at

244_at

3120359

3120360

3120361

3120362

3120384

3120386

3120387

3120388

3120392

3120393

3120394

3120395

3120396

3120397

3120398

3120405

3120407

3120408

3120410

3120411

3120412

3120413

3297

40200_at

4049903

4049904

4049905

4049907

4049908

4049909

4049910

4049918

4049920

4049921

4049922

4049923

4049924

4049927

4049928

4049929

8148824

A_23_P253841

A_33_P3347932

A_33_P3347937

GO:0000122

GO:0000165

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0000785

GO:0000791

GO:0000792

GO:0000922

GO:0000978

GO:0000981

GO:0001162

GO:0001227

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006281

GO:0006355

GO:0006357

GO:0006397

GO:0006464

GO:0006810

GO:0006950

GO:0006952

GO:0006974

GO:0007049

GO:0007165

GO:0007584

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009299

GO:0009408

GO:0010243

GO:0010628

GO:0010629

GO:0010667

GO:0014070

GO:0014823

GO:0016032

GO:0016605

GO:0019899

GO:0019901

GO:0022607

GO:0031072

GO:0031333

GO:0031490

GO:0032355

GO:0032991

GO:0033574

GO:0034605

GO:0034620

GO:0034622

GO:0034641

GO:0034655

GO:0035690

GO:0035865

GO:0042025

GO:0042531

GO:0042592

GO:0042802

GO:0043200

GO:0043226

GO:0043280

GO:0043565

GO:0043621

GO:0044403

GO:0045931

GO:0045944

GO:0046982

GO:0048471

GO:0051028

GO:0051879

GO:0061408

GO:0061770

GO:0065003

GO:0070301

GO:0071222

GO:0071230

GO:0071276

GO:0071280

GO:0071392

GO:0071407

GO:0071478

GO:0071480

GO:0072738

GO:0090084

GO:0090261

GO:0097165

GO:0097431

GO:0097677

GO:0098847

GO:0101031

GO:0120162

GO:1900034

GO:1900365

GO:1901215

GO:1901652

GO:1902512

GO:1903936

GO:1904385

GO:1904528

GO:1904843

GO:1904845

GO:1990837

GO:1990841

GO:1990904

GO:1990910

GO:1990911

GO:2001033

HMNXSV003007205

HMNXSV003033648

Hs.1499.1.S1_3p_a_at

ILMN_1665621

ILMN_1667060

ILMN_1679371

ILMN_1679867

M64673_at

PH_hs_0031748

TC08000849.hg

TC08002160.hg

g5031766_3p_at

g5031766_3p_x_at

Participates

as a component of

p-S303,307-HSF1:YWHAE [cytosol] (Homo sapiens)

as an input of

p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)

Other forms of this molecule

p-S121-HSF1 [cytosol]

p-S303-HSF1 [cytosol]

p-S307-HSF1 [cytosol]

HSF1 [nucleoplasm]

hC36,103-HSF1 [cytosol]

p-S230-hC36,103-HSF1 [nucleoplasm]

p-S326-hC36,103-HSF1 [nucleoplasm]

Ac-K80-hC36,103-HSF1 [nucleoplasm]

HSF1 [cytosol]

hC36,103-HSF1 [nucleoplasm]

Inferred To

phospho-hsf1 [cytosol] (Danio rerio)

phospho-HSF1 [cytosol] (Canis familiaris)

phospho-Hsf1 [cytosol] (Mus musculus)

phospho-Hsf1 [cytosol] (Rattus norvegicus)

phospho-Hsf [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 307

Coordinate

307

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 303

Coordinate

303

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005517.1, XP_016868866.1

OpenTargets

ENSG00000185122

ZINC - Substances

HSF1_HUMAN

ZINC - Biogenic

HSF1_HUMAN

ZINC target

Q00613

PRO

Q00613

PDB

5HDN, 2LDU, 5D5V, 5D5U, 5HDG

ZINC - Metabolites

HSF1_HUMAN

Target Pathogen

5b354852be737e166372e9e9

HPA

ENSG00000185122-HSF1

GeneCards

Q00613

Ensembl

ENST00000528838, ENST00000646252, ENSG00000185122, ENSP00000431512, ENSG00000284774, ENSP00000493830

Orphanet

24605

ZINC - Predictions - Purchasable

HSF1_HUMAN

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03933 HSF2			0.729	8
UniProt:Q9NZL4 HPBP1			0.638	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.638	3
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.638	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.638	3
UniProt:P49137 MAPKAPK2	5	p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.602	5
UniProt:Q5VY09 IER5			0.589	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.571	2
IntAct:EBI-25856799 CCSB			0.556	3
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	3
UniProt:Q96CM3 RUSD4			0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [nucleoplasm] (R-HSA-606325) ITGB3BP [cytosol] (R-HSA-3006405)	0.556	3
UniProt:P11684 UTER			0.556	3
UniProt:Q6ZMY6-2 Q6ZMY62			0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q8N4C8 MINK1	1	MINK1 [cytosol] (R-HSA-2532788)	0.544	2
UniProt:Q04759 PRKCQ	9	p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216)	0.544	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.508	2
UniProt:Q96SB8 SMC6	1	SMC6 [nucleoplasm] (R-HSA-2993777)	0.508	2
UniProt:Q8NEH6 MNS1			0.508	2
UniProt:Q8NET4 RTL9			0.508	2
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.508	2
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.508	2
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q5VZK9 CARMIL1	1	LRRC16A [cytosol] (R-HSA-994131)	0.508	2