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p-S303,307-HSF1 [cytosol]
Stable Identifier
R-HSA-4793922
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S303,307-Heat shock transcription factor 1, HSTF 1, Heat shock factor protein 1
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)
p-S303,307-HSF1 [cytosol] (Homo sapiens)
p-S303,307-HSF1:YWHAE [cytosol] (Homo sapiens)
p-S303,307-HSF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00613 HSF1
Gene Names
HSF1, HSTF1
Chain
chain:1-529
Reference Genes
BioGPS Gene:3297 HSF1
COSMIC (genes):HSF1 HSF1
CTD Gene:3297 HSF1
dbSNP Gene:3297 HSF1
ENSEMBL:ENSG00000185122 HSF1
ENSEMBL:ENSG00000284774 HSF1
HGNC:5224 HSF1
KEGG Gene (Homo sapiens):3297 HSF1
Monarch:3297 HSF1
NCBI Gene:3297 HSF1
OMIM:140580 HSF1
UCSC:Q00613 HSF1
Reference Transcript
RefSeq:NM_005526.3 HSF1
RefSeq:XM_017013377.1 HSF1
Other Identifiers
0005220722
11723695_s_at
17073759
202344_at
213756_s_at
244_at
2LDU
3120359
3120360
3120361
3120362
3120384
3120386
3120387
3120388
3120392
3120393
3120394
3120395
3120396
3120397
3120398
3120405
3120407
3120408
3120410
3120411
3120412
3120413
3297
40200_at
4049903
4049904
4049905
4049907
4049908
4049909
4049910
4049918
4049920
4049921
4049922
4049923
4049924
4049927
4049928
4049929
4239
5D5U
5D5V
5HDG
5HDN
8148824
8888
A0A087WWQ3
A0A087WXG6
A_23_P253841
A_33_P3347932
A_33_P3347937
AAA52695
AAH14638
AAP36015
AC110280
AF205589
AK290975
BAF83664
BC014638
BT007351
CAB004239
CCDS6419
E9PI02
E9PMQ6
ENSG00000185122
ENSG00000284774
ENSP00000431512
ENSP00000493830
ENST00000528838
ENST00000528838.5
ENST00000646252
EntrezGene:3297
EntrezGene:HSF1
g5031766_3p_at
g5031766_3p_x_at
GO:0000003
GO:0000122
GO:0000165
GO:0000228
GO:0000278
GO:0000775
GO:0000776
GO:0000777
GO:0000790
GO:0000791
GO:0000792
GO:0000922
GO:0000978
GO:0000981
GO:0001162
GO:0001227
GO:0001701
GO:0001892
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006281
GO:0006355
GO:0006397
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0006952
GO:0006974
GO:0007049
GO:0007143
GO:0007165
GO:0007283
GO:0007584
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009056
GO:0009058
GO:0009299
GO:0009408
GO:0009790
GO:0010243
GO:0010628
GO:0010629
GO:0010667
GO:0014070
GO:0014823
GO:0016605
GO:0019899
GO:0019901
GO:0022607
GO:0031072
GO:0031490
GO:0032355
GO:0032496
GO:0032720
GO:0032991
GO:0033574
GO:0034605
GO:0034620
GO:0034622
GO:0034641
GO:0034655
GO:0035690
GO:0035865
GO:0040007
GO:0040018
GO:0042531
GO:0042592
GO:0042802
GO:0043200
GO:0043226
GO:0043280
GO:0043497
GO:0043565
GO:0043621
GO:0045120
GO:0045931
GO:0045944
GO:0046982
GO:0048471
GO:0048856
GO:0051028
GO:0051260
GO:0051879
GO:0060136
GO:0061408
GO:0061770
GO:0065003
GO:0070207
GO:0070301
GO:0071222
GO:0071230
GO:0071276
GO:0071280
GO:0071392
GO:0071407
GO:0071478
GO:0071480
GO:0072738
GO:0090084
GO:0090261
GO:0097165
GO:0097431
GO:0097677
GO:0098847
GO:0120162
GO:1900034
GO:1900365
GO:1901215
GO:1901652
GO:1902512
GO:1903936
GO:1904385
GO:1904528
GO:1904843
GO:1904845
GO:1990841
GO:1990904
GO:1990910
GO:1990911
GO:2001033
HGNC:5224
HPA008888
Hs.1499.1.S1_3p_a_at
HSF1
HSF1-204
HSF1-226
ILMN_1665621
ILMN_1667060
ILMN_1679371
ILMN_1679867
IPR000232
IPR010542
IPR027725
IPR036388
IPR036390
M64673
M64673_at
MIM:140580
NM_005526
NP_005517
PF00447
PF06546
PH_hs_0031748
PR00056
SM00415
TC08000849.hg
TC08002160.hg
UPI0000000DE5
XM_005272315
XM_011517004
XM_017013377
XM_024447144
XP_005272372
XP_011515306
XP_016868866
XP_024302912
XR_001745526
XR_001745527
XR_246618
Participant Of
hasComponent
p-S303,307-HSF1:YWHAE [cytosol]
input
p-S303,307-HSF1 binds YWHAE (14-3-3)
Other forms of this molecule
p-S121-HSF1 [cytosol]
p-S303-HSF1 [cytosol]
p-S307-HSF1 [cytosol]
HSF1 [nucleoplasm]
hC36,103-HSF1 [cytosol]
p-S230-hC36,103-HSF1 [nucleoplasm]
p-S326-hC36,103-HSF1 [nucleoplasm]
Ac-K80-hC36,103-HSF1 [nucleoplasm]
HSF1 [cytosol]
hC36,103-HSF1 [nucleoplasm]
Inferred To
Homologues of p-S303,307-HSF1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-S303,307-HSF1 [cytosol] (Bos taurus)
phospho-p-S303,307-HSF1 [cytosol] (Canis familiaris)
phospho-p-S303,307-HSF1 [cytosol] (Danio rerio)
phospho-p-S303,307-HSF1 [cytosol] (Dictyostelium discoideum)
phospho-p-S303,307-HSF1 [cytosol] (Drosophila melanogaster)
phospho-p-S303,307-HSF1 [cytosol] (Mus musculus)
phospho-p-S303,307-HSF1 [cytosol] (Rattus norvegicus)
phospho-p-S303,307-HSF1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-S303,307-HSF1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-S303,307-HSF1 [cytosol] (Sus scrofa)
phospho-p-S303,307-HSF1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 307
Coordinate
307
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 303
Coordinate
303
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016868866.1
,
NP_005517.1
ZINC - Metabolites
HSF1_HUMAN
OpenTargets
ENSG00000185122
ZINC - Substances
HSF1_HUMAN
GeneCards
Q00613
ZINC - Biogenic
HSF1_HUMAN
ZINC target
Q00613
PRO
Q00613
Orphanet
24605
ZINC - Predictions - Purchasable
HSF1_HUMAN
PDB
5HDN
,
5HDG
,
2LDU
,
5D5V
,
5D5U
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03933 HSF2
0.729
8
UniProt:Q9NZL4 HPBP1
0.638
3
UniProt:O00505 KPNA3
2
KPNA3 [cytosol]
(R-HSA-1176070)
KPNA3 [nucleoplasm]
(R-HSA-1176061)
0.638
3
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.638
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.638
3
UniProt:Q00613 HSF1
11
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
HSF1 [cytosol]
(R-HSA-3371452)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
0.609
2
UniProt:P49137 MAPKAPK2
5
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.602
5
UniProt:Q5VY09 IER5
0.589
3
UniProt:Q8N4C8 MINK1
1
MINK1 [cytosol]
(R-HSA-2532788)
0.544
2
UniProt:Q04759 PRKCQ
9
PRKCQ(1-354) [cytosol]
(R-HSA-212526)
PRKCQ [photoreceptor disc membrane]
(R-HSA-2648997)
PRKCQ(355-706) [cytosol]
(R-HSA-212514)
PRKCQ [cytosol]
(R-HSA-58216)
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-2685606)
PRKQC closed conformation [cytosol]
(R-HSA-202185)
PRKCQ [plasma membrane]
(R-HSA-202346)
p-Y90-PRKCQ [plasma membrane]
(R-HSA-202395)
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-202152)
0.544
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:Q8NEH6 MNS1
0.508
2
UniProt:Q8NET4 RTL9
0.508
2
UniProt:P34931 HSPA1L
2
HSPA1L [nucleoplasm]
(R-HSA-5082367)
HSPA1L [cytosol]
(R-HSA-3371410)
0.508
2
UniProt:Q96SB8 SMC6
1
SMC6 [nucleoplasm]
(R-HSA-2993777)
0.508
2
UniProt:O43683 BUB1
1
BUB1 [cytosol]
(R-HSA-377888)
0.508
2
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.508
2
UniProt:Q5VZK9 CARMIL1
1
LRRC16A [cytosol]
(R-HSA-994131)
0.508
2
UniProt:P53350 PLK1
4
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [cytosol]
(R-HSA-164603)
0.508
2
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