Reactome | MTA1 [nucleoplasm]

MTA1 [nucleoplasm]

Stable Identifier

R-HSA-3465550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Metastasis-associated protein MTA1, MTA1_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13330 MTA1

Gene Names

MTA1

Chain

chain:1-715

Reference Genes

BioGPS Gene:9112 MTA1

COSMIC (genes):MTA1 MTA1

CTD Gene:9112 MTA1

dbSNP Gene:9112 MTA1

ENSEMBL:ENSG00000182979 MTA1

ENSEMBL:ENSG00000182979.18 MTA1

HGNC:7410 MTA1

KEGG Gene (Homo sapiens):9112 MTA1

Monarch:9112 MTA1

NCBI Gene:9112 MTA1

OMIM:603526 MTA1

UCSC:Q13330 MTA1

Reference Transcript

Other Identifiers

11727668_a_at

11746358_a_at

11757774_x_at

1642_at

1643_g_at

16789681

202247_PM_s_at

202247_s_at

211783_PM_s_at

211783_s_at

3554748

3554749

3554760

3554767

3554776

3554778

3554780

3554781

3554785

3554787

3554788

3554790

3554792

3554794

3554795

3554796

3554797

3554799

3554800

3554802

3554805

3554806

3554810

3554812

3554813

3554815

3554816

3554817

38633_at

7977373

9112

A_14_P123899

A_23_P9513

A_24_P241370

A_33_P3359306

GE59104

GO:0000122

GO:0000978

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0006281

GO:0006302

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0007165

GO:0010212

GO:0016575

GO:0016581

GO:0023052

GO:0030154

GO:0030163

GO:0032922

GO:0036211

GO:0040029

GO:0042659

GO:0042826

GO:0043153

GO:0043161

GO:0043226

GO:0043231

GO:0043565

GO:0045475

GO:0045892

GO:0045893

GO:0046872

GO:0048511

GO:0061629

GO:0140110

GO:1902499

GO:2000736

HMNXSV003027770

Hs.101448.0.S1_3p_s_at

ILMN_1671911

PH_hs_0005642

TC14000836.hg

U35113_at

g13544097_3p_s_at

Participates

as an input of

PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-K509-MTA1 [nucleoplasm]

Inferred To

MTA1-like [nucleoplasm] (Drosophila melanogaster)

lin-40 [nucleoplasm] (Caenorhabditis elegans)

MTA1 [nucleoplasm] (Bos taurus)

MTA1 [nucleoplasm] (Canis familiaris)

MTA1 [nucleoplasm] (Danio rerio)

MTA1 [nucleoplasm] (Gallus gallus)

MTA1 [nucleoplasm] (Sus scrofa)

mybS [nucleoplasm] (Dictyostelium discoideum)

Mta1 [nucleoplasm] (Mus musculus)

Mta1 [nucleoplasm] (Rattus norvegicus)

mta1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001190187.1, NP_004680.2

OpenTargets

ENSG00000182979

HPA

ENSG00000182979-MTA1

GeneCards

Q13330

Ensembl

ENSP00000393438, ENSP00000384180, ENST00000331320, ENST00000405646, ENST00000438610, ENSP00000333633, ENSG00000182979

PRO

Q13330

Pharos - Targets

Q13330

Orphanet

29654

PDB

4PBZ, 4BKX, 6ZRC, 5FXY, 7AO9, 6G16, 6ZRD, 7AOA, 4PC0, 7AO8, 5ICN, 4PBY

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.914	12
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.848	6
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.832	10
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.666	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.612	12
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.597	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.59	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.577	9
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q6FGM0 Q6FGM0			0.556	3
UniProt:Q58EX7 PLEKHG4	1	PLEKHG4 [cytosol] (R-HSA-9679579)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P0DPK4 NT2NC			0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.556	3
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.556	6
UniProt:O14519 CDKA1			0.527	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	4
UniProt:Q9NSY1 BMP2K			0.488	2
UniProt:A2A935	1	Prdm16 [cytosol] (R-MMU-5634812)	0.462	2