Reactome | MTA1 [nucleoplasm]

MTA1 [nucleoplasm]

Stable Identifier

R-HSA-3465550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Metastasis-associated protein MTA1, MTA1_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13330 MTA1

Gene Names

MTA1

Chain

chain:1-715

Reference Genes

BioGPS Gene:9112 MTA1

COSMIC (genes):MTA1 MTA1

CTD Gene:9112 MTA1

dbSNP Gene:9112 MTA1

ENSEMBL:ENSG00000182979 MTA1

HGNC:7410 MTA1

KEGG:hsa:9112 MTA1

Monarch:9112 MTA1

NCBI Gene:9112 MTA1

OMIM:603526 MTA1

UCSC:Q13330 MTA1

Reference Transcript

Other Identifiers

11727668_a_at

11746358_a_at

11757774_x_at

1642_at

1643_g_at

16789681

202247_PM_s_at

202247_s_at

211783_PM_s_at

211783_s_at

3554746

3554747

3554748

3554749

3554759

3554760

3554767

3554768

3554774

3554775

3554776

3554778

3554779

3554780

3554781

3554784

3554785

3554787

3554788

3554789

3554790

3554791

3554792

3554793

3554794

3554795

3554796

3554797

3554798

3554799

3554800

3554801

3554802

3554803

3554804

3554805

3554806

3554807

3554808

3554810

3554811

3554812

3554813

3554815

3554816

3554817

38633_at

7977373

9112

A_14_P105611

A_14_P119329

A_14_P123297

A_14_P123899

A_23_P9513

A_24_P241370

A_24_P241373

A_33_P3359306

GE59104

GO:0000122

GO:0000978

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0006281

GO:0006302

GO:0006325

GO:0006338

GO:0006355

GO:0007165

GO:0010212

GO:0016581

GO:0030163

GO:0032922

GO:0042659

GO:0042826

GO:0043153

GO:0043161

GO:0043226

GO:0043231

GO:0043565

GO:0045475

GO:0045814

GO:0045892

GO:0045893

GO:0046872

GO:0048511

GO:0060090

GO:0061629

GO:0140110

GO:1902499

GO:2000736

HMNXSV003027770

Hs.101448.0.S1_3p_s_at

ILMN_1671911

PH_hs_0005642

TC14000836.hg

U35113_at

g13544097_3p_s_at

Participates

as an input of

PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-K509-MTA1 [nucleoplasm]

Inferred To

MTA1-like [nucleoplasm] (Drosophila melanogaster)

lin-40 [nucleoplasm] (Caenorhabditis elegans)

MTA1 [nucleoplasm] (Bos taurus)

MTA1 [nucleoplasm] (Canis familiaris)

MTA1 [nucleoplasm] (Gallus gallus)

MTA1 [nucleoplasm] (Sus scrofa)

mybS [nucleoplasm] (Dictyostelium discoideum)

Mta1 [nucleoplasm] (Mus musculus)

Mta1 [nucleoplasm] (Rattus norvegicus)

mta1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001190187.1, NP_004680.2

OpenTargets

ENSG00000182979

ENSEMBL

ENST00000331320, ENST00000405646, ENST00000438610, ENSP00000333633, ENSP00000393438, ENSP00000384180

HPA

ENSG00000182979-MTA1

PRO

Q13330

Pharos - Targets

Q13330

GlyGen

Q13330

PDB

4PBZ, 7AO9, 6ZRC, 4PC0, 7AOA, 4PBY, 5FXY, 4BKX, 5ICN, 7AO8, 6G16, 6ZRD

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.929	16
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.904	14
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.886	7
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	6
UniProt:Q13422 IKZF1			0.666	5
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.666	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.666	4
UniProt:O14519 CDKA1			0.643	4
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.612	12
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.597	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.59	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.577	9
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.556	6
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.556	3
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q58EX7 PLEKHG4	1	PLEKHG4 [cytosol] (R-HSA-9679579)	0.556	3
UniProt:Q6FGM0 Q6FGM0			0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	4
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.527	3
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.527	2
UniProt:Q9NSY1 BMP2K			0.488	2
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.483	2
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.483	2
UniProt:A2A935 Prdm16	2	Prdm16 [nucleoplasm] (R-MMU-9854760) Prdm16 [cytosol] (R-MMU-5634812)	0.462	2