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ACTN2 [platelet alpha granule lumen]
Stable Identifier
R-HSA-349727
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Alpha-actinin 2
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Alpha actinins [platelet alpha granule lumen] (Homo sapiens)
ACTN2 [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35609 ACTN2
Gene Names
ACTN2
Chain
chain:1-894
Reference Genes
BioGPS Gene:88 ACTN2
COSMIC (genes):ACTN2 ACTN2
CTD Gene:88 ACTN2
dbSNP Gene:88 ACTN2
ENSEMBL:ENSG00000077522 ACTN2
HGNC:164 ACTN2
KEGG:hsa:88 ACTN2
Monarch:88 ACTN2
NCBI Gene:88 ACTN2
OMIM:102573 ACTN2
UCSC:P35609 ACTN2
Reference Transcript
RefSeq:NM_001278344.1 ACTN2
RefSeq:NM_001278343.1 ACTN2
RefSeq:NM_001103.3 ACTN2
Other Identifiers
11734001_at
11734002_a_at
11734003_at
11749692_a_at
11751575_a_at
11758470_s_at
16679064
203861_PM_s_at
203861_s_at
203862_PM_s_at
203862_s_at
203863_PM_at
203863_at
203864_PM_s_at
203864_s_at
2386944
2386945
2386955
2386956
2386957
2386958
2386959
2386960
2386963
2386965
2386966
2386967
2386968
2386969
2386970
2386971
2386972
2386973
2386974
2386975
2386976
2386977
2386979
2386982
2386984
2386985
2386986
2386987
2386988
2386989
2386990
2386991
2386992
2386993
2386994
2386996
2386997
2386998
2386999
2387000
2387001
2387002
2387003
2387004
2387005
38448_at
61882_at
7910727
88
A_23_P115021
A_33_P3212167
GE61094
GE84365
GO:0003779
GO:0005178
GO:0005198
GO:0005509
GO:0005515
GO:0005546
GO:0005576
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006355
GO:0007010
GO:0007155
GO:0008092
GO:0008289
GO:0008307
GO:0019904
GO:0030017
GO:0030018
GO:0030035
GO:0030036
GO:0030054
GO:0030175
GO:0030274
GO:0030374
GO:0030864
GO:0031093
GO:0031143
GO:0031432
GO:0034330
GO:0042391
GO:0042802
GO:0042981
GO:0042995
GO:0043197
GO:0043226
GO:0043267
GO:0043268
GO:0044325
GO:0045214
GO:0045893
GO:0046872
GO:0048041
GO:0048856
GO:0051015
GO:0051373
GO:0051695
GO:0055001
GO:0055013
GO:0060090
GO:0070062
GO:0070080
GO:0072659
GO:0086097
GO:0098839
GO:0098871
GO:0098973
GO:0098978
GO:0099092
GO:0140110
GO:1901017
GO:1901018
GO:2000009
GO:2001137
GO:2001259
HMNXSV003055491
Hs.83672.0.S1_3p_a_at
Hs.83672.0.S2_3p_a_at
Hs.83672.0.S4_3p_at
ILMN_1654422
M86406_at
PH_hs_0004772
TC01001955.hg
g4501892_3p_a_at
Participates
as a member of
Alpha actinins [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
ACTN2 [cytosol]
ACTN2 [extracellular region]
Inferred To
actn2b [platelet alpha granule lumen]
(Danio rerio)
Actn2 [platelet alpha granule lumen]
(Rattus norvegicus)
ain1 [platelet alpha granule lumen]
(Schizosaccharomyces pombe)
atn-1 [platelet alpha granule lumen]
(Caenorhabditis elegans)
Homologues of ACTN2 [platelet alpha granule lumen]
(Dictyostelium discoideum)
ACTN2 [platelet alpha granule lumen]
(Bos taurus)
ACTN2 [platelet alpha granule lumen]
(Canis familiaris)
ACTN2 [platelet alpha granule lumen]
(Dictyostelium discoideum)
ACTN2 [platelet alpha granule lumen]
(Drosophila melanogaster)
ACTN2 [platelet alpha granule lumen]
(Gallus gallus)
ACTN2 [platelet alpha granule lumen]
(Mus musculus)
ACTN2 [platelet alpha granule lumen]
(Sus scrofa)
abpD [platelet alpha granule lumen]
(Dictyostelium discoideum)
actn2 [platelet alpha granule lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001265272.1
,
NP_001265273.1
,
NP_001094.1
OpenTargets
ENSG00000077522
ENSEMBL
ENSP00000443495
,
ENSP00000355537
,
ENST00000366578
,
ENST00000542672
HPA
ENSG00000077522-ACTN2
PRO
P35609
Pharos - Targets
P35609
Orphanet
ACTN2
GlyGen
P35609
PDB
1H8B
,
1QUU
,
4D1E
,
7B55
,
5A37
,
5A38
,
7B56
,
7B57
,
7A8U
,
7A8T
,
5A4B
,
6SWT
,
5A36
,
1HCI
,
6TS3
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.781
7
UniProt:P23497 SP100
3
polySUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
monoSUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.666
6
UniProt:P03950 ANG
2
ANG [extracellular region]
(R-HSA-5692435)
ANG [cytosol]
(R-HSA-9708345)
0.633
4
UniProt:P26842 CD27
1
CD27 [plasma membrane]
(R-HSA-5666994)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.556
3
UniProt:P29373 CRABP2
2
SUMO-K102-CRABP2 [nucleoplasm]
(R-HSA-5334813)
SUMO-K102-CRABP2 [cytosol]
(R-HSA-5334798)
0.556
3
UniProt:P78560 CRADD
1
CRADD [cytosol]
(R-HSA-5657970)
0.556
3
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
0.556
3
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.556
3
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.556
3
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.547
2
UniProt:O75923 DYSF
1
DYSF [cytoplasmic vesicle membrane]
(R-HSA-5263626)
0.454
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.454
2
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