Reactome | SUMO1-HIST1H4 [nucleoplasm]

SUMO1-HIST1H4 [nucleoplasm]

Stable Identifier

R-HSA-4570518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H4, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of Histone H4 with SUMO1 (Homo sapiens)
        
        SUMO1:HIST1H4 [nucleoplasm] (Homo sapiens)
        
        SUMO1-HIST1H4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62805 H4C1

Gene Names

H4C1, H4/A, H4FA, HIST1H4A, H4C2, H4/I, H4FI, HIST1H4B, H4C3, H4/G, H4FG, HIST1H4C, H4C4, H4/B, H4FB, HIST1H4D, H4C5, H4/J, H4FJ, HIST1H4E, H4C6, H4/C, H4FC, HIST1H4F, H4C8, H4/H, H4FH, HIST1H4H, H4C9, H4/M, H4FM, HIST1H4I, H4C11, H4/E, H4FE, HIST1H4J, H4C12, H4/D, H4FD, HIST1H4K, H4C13, H4/K, H4FK, HIST1H4L, H4C14, H4/N, H4F2, H4FN, HIST2H4, HIST2H4A, H4C15, H4/O, H4FO, HIST2H4B, H4-16, HIST4H4

Chain

initiator methionine:1, chain:2-103

Reference Genes

BioGPS Gene:121504 H4C1

BioGPS Gene:554313 H4C1

BioGPS Gene:8294 H4C1

BioGPS Gene:8359 H4C1

BioGPS Gene:8360 H4C1

BioGPS Gene:8361 H4C1

BioGPS Gene:8362 H4C1

BioGPS Gene:8363 H4C1

BioGPS Gene:8364 H4C1

BioGPS Gene:8365 H4C1

BioGPS Gene:8366 H4C1

BioGPS Gene:8367 H4C1

BioGPS Gene:8368 H4C1

BioGPS Gene:8370 H4C1

CTD Gene:121504 H4C1

CTD Gene:554313 H4C1

CTD Gene:8294 H4C1

CTD Gene:8359 H4C1

CTD Gene:8360 H4C1

CTD Gene:8361 H4C1

CTD Gene:8362 H4C1

CTD Gene:8363 H4C1

CTD Gene:8364 H4C1

CTD Gene:8365 H4C1

CTD Gene:8366 H4C1

CTD Gene:8367 H4C1

CTD Gene:8368 H4C1

CTD Gene:8370 H4C1

dbSNP Gene:121504 H4C1

dbSNP Gene:554313 H4C1

dbSNP Gene:8294 H4C1

dbSNP Gene:8359 H4C1

dbSNP Gene:8360 H4C1

dbSNP Gene:8361 H4C1

dbSNP Gene:8362 H4C1

dbSNP Gene:8363 H4C1

dbSNP Gene:8364 H4C1

dbSNP Gene:8365 H4C1

dbSNP Gene:8366 H4C1

dbSNP Gene:8367 H4C1

dbSNP Gene:8368 H4C1

dbSNP Gene:8370 H4C1

ENSEMBL:ENSG00000158406 HIST1H4A

ENSEMBL:ENSG00000197061 HIST1H4A

ENSEMBL:ENSG00000197238 HIST1H4A

ENSEMBL:ENSG00000197837 HIST1H4A

ENSEMBL:ENSG00000270276 HIST1H4A

ENSEMBL:ENSG00000270882 HIST1H4A

ENSEMBL:ENSG00000273542 HIST1H4A

ENSEMBL:ENSG00000274618 HIST1H4A

ENSEMBL:ENSG00000275126 HIST1H4A

ENSEMBL:ENSG00000276180 HIST1H4A

ENSEMBL:ENSG00000276966 HIST1H4A

ENSEMBL:ENSG00000277157 HIST1H4A

ENSEMBL:ENSG00000278637 HIST1H4A

ENSEMBL:ENSG00000278705 HIST1H4A

HGNC:20510 H4C1

HGNC:29607 H4C1

HGNC:4781 H4C1

HGNC:4782 H4C1

HGNC:4783 H4C1

HGNC:4784 H4C1

HGNC:4785 H4C1

HGNC:4787 H4C1

HGNC:4788 H4C1

HGNC:4789 H4C1

HGNC:4790 H4C1

HGNC:4791 H4C1

HGNC:4793 H4C1

HGNC:4794 H4C1

KEGG Gene (Homo sapiens):121504 H4C1

KEGG Gene (Homo sapiens):554313 H4C1

KEGG Gene (Homo sapiens):8294 H4C1

KEGG Gene (Homo sapiens):8359 H4C1

KEGG Gene (Homo sapiens):8360 H4C1

KEGG Gene (Homo sapiens):8361 H4C1

KEGG Gene (Homo sapiens):8362 H4C1

KEGG Gene (Homo sapiens):8363 H4C1

KEGG Gene (Homo sapiens):8364 H4C1

KEGG Gene (Homo sapiens):8365 H4C1

KEGG Gene (Homo sapiens):8366 H4C1

KEGG Gene (Homo sapiens):8367 H4C1

KEGG Gene (Homo sapiens):8368 H4C1

KEGG Gene (Homo sapiens):8370 H4C1

Monarch:121504 H4C1

Monarch:554313 H4C1

Monarch:8294 H4C1

Monarch:8359 H4C1

Monarch:8360 H4C1

Monarch:8361 H4C1

Monarch:8362 H4C1

Monarch:8363 H4C1

Monarch:8364 H4C1

Monarch:8365 H4C1

Monarch:8366 H4C1

Monarch:8367 H4C1

Monarch:8368 H4C1

Monarch:8370 H4C1

NCBI Gene:121504 H4C1

NCBI Gene:554313 H4C1

NCBI Gene:8294 H4C1

NCBI Gene:8359 H4C1

NCBI Gene:8360 H4C1

NCBI Gene:8361 H4C1

NCBI Gene:8362 H4C1

NCBI Gene:8363 H4C1

NCBI Gene:8364 H4C1

NCBI Gene:8365 H4C1

NCBI Gene:8366 H4C1

NCBI Gene:8367 H4C1

NCBI Gene:8368 H4C1

NCBI Gene:8370 H4C1

OMIM:142750 H4C1

OMIM:602822 H4C1

OMIM:602823 H4C1

OMIM:602824 H4C1

OMIM:602825 H4C1

OMIM:602826 H4C1

OMIM:602827 H4C1

OMIM:602828 H4C1

OMIM:602829 H4C1

OMIM:602830 H4C1

OMIM:602831 H4C1

OMIM:602833 H4C1

OMIM:615069 H4C1

UCSC:P62805 H4C1

Reference Transcript

Other Identifiers

0001050411

0002190092

0002760136

0003140609

0003520324

0003610035

0003800215

0004010551

0004120750

0004570465

0005570082

0005570184

0006110717

11715116_s_at

11726245_s_at

11726246_x_at

11728049_s_at

11733368_at

11733369_x_at

11735753_at

11735775_at

11735776_x_at

11735942_at

11737314_at

11738060_s_at

11738103_at

11738601_at

11741794_s_at

11742669_s_at

11759221_at

121504

152_f_at

16670377

16692626

16761778

17005560

17005586

17005790

17005868

17016360

17016383

17016406

17016494

17016506

205967_at

206951_at

207046_at

208046_at

208076_at

208180_s_at

208580_x_at

214463_x_at

214516_at

214562_at

214634_at

232035_at

2357894

2357895

2357896

2357897

2357898

2357899

2357900

2357901

2357902

2357903

2357904

2357906

2357910

2434056

2434103

2434104

2434105

2434106

2434107

2434108

2434109

2434110

2434111

2434116

2899096

2899097

2899147

2899148

2899149

2899217

2899218

2899219

2899220

2899244

2899245

2899246

2899247

2899248

2899769

2899770

2899771

2900064

2900065

2946209

2946210

2946211

2946212

2946213

2946214

2946320

2946321

2946377

2946379

2946380

2946382

2946384

2946387

2946388

2946389

2947057

2947058

2947082

2947083

2947084

31521_f_at

31751_f_at

33049_at

34027_f_at

3445648

3445649

3445653

3445654

3445655

3445656

3445661

39969_at

50025_at

554313

57785_at

59154_at

762_f_at

7905067

7919627

7961483

81125_at

8117334

8117368

8117402

8117422

8117537

8117598

8124385

8124413

8124448

8124521

8124534

8180255

8180321

82468_at

8294

8359

8360

8361

8362

8363

8364

8365

8366

8367

8368

8370

AB000905_at

ADDON000875.hg

ADDON001483.hg

ADDON002748.hg

ADDON002749.hg

ADDON002750.hg

ADDON002752.hg

ADDON002753.hg

ADDON002754.hg

ADDON002776.hg

ADDON002784.hg

ADDON002794.hg

ADDON002882.hg

A_14_P107645

A_14_P121153

A_14_P137590

A_21_P0014172

A_23_P214487

A_23_P30805

A_23_P30813

A_23_P323685

A_23_P359540

A_23_P388871

A_23_P395374

A_23_P415411

A_23_P431179

A_23_P436281

A_23_P70480

A_24_P166407

A_24_P20873

A_24_P261691

A_33_P3299865

A_33_P3344229

A_33_P3351851

A_33_P3410836

GE499003

GE501244

GE502647

GE506852

GE508495

GE572531

GE57844

GE58304

GE59861

GE79334

GE81299

GE81300

GE86856

GE87998

GO:0000183

GO:0000228

GO:0000784

GO:0000786

GO:0000788

GO:0002376

GO:0003674

GO:0003677

GO:0003723

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006303

GO:0006334

GO:0006335

GO:0006336

GO:0006352

GO:0006950

GO:0008150

GO:0009058

GO:0016020

GO:0016233

GO:0019904

GO:0022607

GO:0030154

GO:0032200

GO:0032991

GO:0034080

GO:0034641

GO:0042592

GO:0043226

GO:0044267

GO:0045652

GO:0045653

GO:0045814

GO:0046982

GO:0048856

GO:0051276

GO:0060964

GO:0065003

GO:0070062

Hs.131957.0.S1_3p_at

Hs.143080.0.S1_3p_at

Hs.248172.0.S2_3p_at

Hs.93758.1.S1_3p_at

Hs.93758.1.S1_3p_x_at

ILMN_1662359

ILMN_1670033

ILMN_1676580

ILMN_1681542

ILMN_1695199

ILMN_1698511

ILMN_1704284

ILMN_1708811

ILMN_1713436

ILMN_1723111

ILMN_1751120

ILMN_1777454

ILMN_1782329

ILMN_1797905

ILMN_2053992

ILMN_2075334

ILMN_2115340

ILMN_2119320

ILMN_2165369

ILMN_2224990

ILMN_3238233

M16707_rna1_at

M16707_rna1_s_at

PH_hs_0007863

PH_hs_0012922

PH_hs_0013176

PH_hs_0013177

PH_hs_0017043

PH_hs_0027130

PH_hs_0028888

PH_hs_0029036

PH_hs_0029514

PH_hs_0031203

PH_hs_0031792

PH_hs_0032299

PH_hs_0032446

PH_hs_0033270

PH_hs_0034759

PH_hs_0034804

TC01001173.hg

TC01003192.hg

TC06000163.hg

TC06000166.hg

TC06000172.hg

TC06000175.hg

TC06000224.hg

TC06000266.hg

TC06001341.hg

TC06001348.hg

TC06001355.hg

TC06001424.hg

TC06001428.hg

TC06002644.hg

TC12001272.hg

X00038_at

X60486_at

X60487_at

X67081_at

Z80787_at

g11415029_3p_x_at

g4504322_3p_at

g5579462_3p_at

g5579465_3p_at

g5579466_3p_a_at

g5579467_3p_at

Participant Of

hasComponent

SUMO1:HIST1H4 [nucleoplasm]

Other forms of this molecule

HIST1H4A [extracellular region]

SUMO3-HIST1H4 [nucleoplasm]

4xAcK-HIST1H4A [nucleoplasm]

AcK5,12-HIST1H4A [nucleoplasm]

AcK17-HIST1H4 [nucleoplasm]

AcK13-HIST1H4 [nucleoplasm]

AcK6-HIST1H4 [nucleoplasm]

AcK17-HIST1H4 [nucleoplasm]

AcK9-HIST1H4 [nucleoplasm]

Me2aR4-HIST1H4 [nucleoplasm]

Me2sR4-HIST1H4 [nucleoplasm]

MeR4-HIST1H4 [nucleoplasm]

Me3K21-HIST1H4 [nucleoplasm]

MeK21-HIST1H4 [nucleoplasm]

AcK-HIST1H4 [nucleoplasm]

MeK-HIST1H4A [nucleoplasm]

HIST1H4 [nucleoplasm]

Me2K21-HIST1H4 [nucleoplasm]

Inferred To

hhf3 [nucleoplasm] (Schizosaccharomyces pombe)

H4b [nucleoplasm] (Dictyostelium discoideum)

H4c11 [nucleoplasm] (Mus musculus)

SUMO1-HIST1H4 [nucleoplasm] (Bos taurus)

SUMO1-HIST1H4 [nucleoplasm] (Gallus gallus)

SUMO1-HIST1H4 [nucleoplasm] (Plasmodium falciparum)

SUMO1-HIST1H4 [nucleoplasm] (Sus scrofa)

SUMO1-HIST1H4 [nucleoplasm] (Xenopus tropicalis)

his-56 [nucleoplasm] (Caenorhabditis elegans)

H4-16 [nucleoplasm] (Canis familiaris)

Homologues of SUMO1-HIST1H4 [nucleoplasm] (Bos taurus)

H4c2 [nucleoplasm] (Rattus norvegicus)

HHF2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at unknown and 97

Modification

glycyl group

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_003537.1, NP_003532.1, NP_778224.1, NP_068803.1, NP_003533.1, NP_003486.1, NP_003539.1, NP_003530.1, NP_003534.1, NP_003535.1, NP_003529.1, NP_003531.1, NP_001029249.1, NP_003536.1

OpenTargets

ENSG00000278637

HPA

ENSG00000270882-HIST2H4A, ENSG00000274618-HIST1H4F, ENSG00000197238-HIST1H4J, ENSG00000197837-HIST4H4, ENSG00000277157-HIST1H4D, ENSG00000158406-HIST1H4H, ENSG00000276966-HIST1H4E, ENSG00000278705-HIST1H4B, ENSG00000275126-HIST1H4L, ENSG00000270276-HIST2H4B, ENSG00000278637-HIST1H4A, ENSG00000197061-HIST1H4C, ENSG00000276180-HIST1H4I, ENSG00000273542-HIST1H4K

GeneCards

P62805

ZINC target

P62805

Ensembl

ENST00000377803, ENSP00000479794, ENST00000615353, ENST00000358064, ENSP00000443017, ENST00000618305, ENSP00000482412, ENSG00000277157, ENSP00000478786, ENSP00000478519, ENSP00000366956, ENST00000614272, ENST00000578186, ENSP00000350767, ENSP00000484789, ENSG00000276966, ENSP00000366974, ENSP00000489236, ENSG00000278705, ENST00000612061, ENSP00000367034, ENSG00000197837, ENSP00000489319, ENST00000635491, ENSP00000481507, ENSP00000479461, ENSG00000273542, ENST00000613412, ENSP00000489567, ENSP00000479106, ENSP00000347168, ENSP00000462355, ENST00000377727, ENSG00000270882, ENSG00000274618, ENSG00000158406, ENSP00000481486, ENST00000579512, ENST00000244537, ENST00000621520, ENST00000614247, ENST00000615164, ENST00000634956, ENSG00000276180, ENSP00000462667, ENSG00000197061, ENST00000617569, ENST00000618193, ENSP00000480960, ENSP00000244537, ENST00000377745, ENST00000539745, ENST00000634560, ENSP00000481343, ENST00000355057, ENSG00000278637, ENSG00000197238, ENSG00000270276, ENST00000611927, ENSG00000275126

PRO

P62805

Orphanet

24599

PDB

5AV5, 5GTC, 5XF4, 3NQU, 3W98, 6V92, 5B0Z, 4QYD, 6J4X, 3AN2, 6J51, 5AY8, 6SEG, 3AZM, 4QUU, 4YYJ, 6KVD, 5B2I, 4GQB, 6ACP, 4H9O, 6FML, 4Z5T, 4M38, 3AZH, 6K1K, 3AZL, 3F9Z, 6JR1, 5AV8, 2KWO, 3QZV, 6R93, 6MUO, 2QQS, 5Y0D, 4YYH, 5Z30, 6L49, 6K1I, 5FWE, 6UHD, 3UW9, 5YE3, 1ZKK, 3JPX, 6JR0, 3AFA, 6A5P, 3CFV, 6HKT, 3QZS, 5JA4, 5GSU, 6INQ, 6C0W, 4U9W, 6E0C, 6A5U, 6R90, 5B33, 3WA9, 3UVX, 6IR9, 3X1U, 5CPI, 6A5L, 4YYG, 5GT3, 3AYW, 4H9P, 3WTP, 3IJ1, 5B2J, 3AZK, 3F9Y, 5CPJ, 3W97, 6SE6, 3AV2, 5C3I, 4YYM, 6J4Y, 5XF5, 5BO0, 4H9R, 6SEF, 5B24, 4YM6, 4YY6, 3AZJ, 3X1S, 3AZF, 3F9X, 3AV1, 4YYI, 6UPK, 4H9N, 6R0C, 2IG0, 2RJE, 5FFW, 6J4W, 5TEG, 3W99, 4N3W, 2BQZ, 5AV6, 3NQJ, 5JRG, 6UPL, 5XF3, 6R8Z, 6L4A, 5X7X, 6J50, 5AVB, 6MUP, 6BUZ, 6A5T, 4YYK, 6MLC, 5GSE, 3UVY, 4YM5, 6K1J, 3WAA, 5YE4, 5GT0, 6A5R, 5B0Y, 5AV9, 3A6N, 6R92, 2RNY, 2KWN, 5ZBX, 3AZN, 5Y0C, 5B32, 6R91, 4YYN, 5B40, 4H9S, 6SE0, 3AZE, 2CV5, 3UVW, 3AZI, 3X1T, 3F9W, 3O36, 6A5O, 3QZT, 3CFS, 3QBY, 5ZGC, 6R94, 6RNY, 6HTS, 4YYD, 5FA5, 5CPK, 4N4F, 3W96, 2RS9, 6J4Z, 5Z23, 6SEE, 5AVC, 6R8Y, 6E0P, 3X1V, 5BNV, 4Z2M, 3AZG, 4QUT, 2LVM, 6O1D, 5B31, 4H9Q, 3R45, 5KDM, 3WKJ, 4HGA, 5GXQ, 5BNX

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.925	14
UniProt:P68431 H3C1	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.891	7
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.87	14
UniProt:P84243 H3-3A	15	MeK-H3F3A [nucleoplasm] (R-HSA-427369) H3F3A [extracellular region] (R-HSA-977567) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [nucleoplasm] (R-HSA-212295) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.861	12
UniProt:P04908 H2AC4	13	K63polyUb-HIST1H2AB [nucleoplasm] (R-HSA-6783287) HIST1H2AB [extracellular region] (R-HSA-977555) Ub-HIST1H2AB [nucleoplasm] (R-HSA-6782483) Ack6-HIST1H2AB [nucleoplasm] (R-HSA-4568598) Ack-HIST1H2AB [nucleoplasm] (R-HSA-4551332) Me2aR30-HIST1H2AB [nucleoplasm] (R-HSA-5244538) MeR30-HIST1H2AB [nucleoplasm] (R-HSA-5244576) Me2aR4-HIST1H2AB [nucleoplasm] (R-HSA-5244628) MeR4-HIST1H2AB [nucleoplasm] (R-HSA-5244595) Me2sR4-HIST1H2AB [nucleoplasm] (R-HSA-5218304) Me2aR12-HIST1H2AB [nucleoplasm] (R-HSA-5229308) MeR12-HIST1H2AB [nucleoplasm] (R-HSA-5229221) HIST1H2AB [nucleoplasm] (R-HSA-181888)	0.835	11
UniProt:P49450 CENPA	2	CENPA [nucleoplasm] (R-HSA-606322) CENPA [cytosol] (R-HSA-375317)	0.793	6
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.793	9
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.756	6
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.748	9
UniProt:P16104 H2AX	7	p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.744	4
UniProt:O75164 KDM4A	2	KDM4A [nucleoplasm] (R-HSA-351646) K48PolyUb-KDM4A [nucleoplasm] (R-HSA-5683049)	0.743	7
UniProt:O60885-1 BRD4			0.739	10
IntAct:EBI-10097414 FOXP3			0.725	4
UniProt:Q12888-1 TP53BP1			0.722	3
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.71	5
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.704	7
UniProt:Q71DI3 H3C15	57	MeK-HIST2H3A [nucleoplasm] (R-HSA-417240) HIST2H3A [extracellular region] (R-HSA-977578) 2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) AcK24-HIST2H3A [nucleoplasm] (R-HSA-4568747) AcK19-HIST2H3A [nucleoplasm] (R-HSA-4568750) AcK15-HIST2H3A [nucleoplasm] (R-HSA-4568755) AcK5-HIST2H3A [nucleoplasm] (R-HSA-4568752) Ack15-HIST2H3A [nucleoplasm] (R-HSA-4549224) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5229060) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me3K10-HIST2H3A [nucleoplasm] (R-HSA-4754191) Me3K28-HIST2H3A [nucleoplasm] (R-HSA-4754178) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) Me2K10-HIST2H3A [nucleoplasm] (R-HSA-4724280) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803) Me3K37-HIST2H3A [nucleoplasm] (R-HSA-5638140) Me2K37-HIST2H3A [nucleoplasm] (R-HSA-4722126) MeK10-HIST2H3A [nucleoplasm] (R-HSA-4724283) MeK28-HIST2H3A [nucleoplasm] (R-HSA-5638326) MeK10-HIST2H3A [cytosol] (R-HSA-8943828) HIST2H3A [cytosol] (R-HSA-8943831) Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-5244518) MeK5-HIST2H3A [nucleoplasm] (R-HSA-4687009) Cit27-HIST2H3A [nucleoplasm] (R-HSA-5246539) Cit9-HIST2H3A [nucleoplasm] (R-HSA-5246545) Cit18-HIST2H3A [nucleoplasm] (R-HSA-5246536) MeR18-HIST2H3A [nucleoplasm] (R-HSA-5229044) MeR3-HIST2H3A [nucleoplasm] (R-HSA-5244520) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5244804) MeR9-HIST2H3A [nucleoplasm] (R-HSA-5244803) Ack10-HIST2H3A [nucleoplasm] (R-HSA-4568924) Me2K5,Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-8936570) Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-427407) p-T12-HIST2H3A [nucleoplasm] (R-HSA-5625871) p-T12,MeK-HIST2H3A [nucleoplasm] (R-HSA-5625857) Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-427744) p-T12, Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-5625792) p-T12, Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-5625754) Me3K5-HIST2H3A [nucleoplasm] (R-HSA-1214223) HIST2H3A [nucleoplasm] (R-HSA-212281) Me3K-28-HIST2H3A [nucleoplasm] (R-HSA-212253) Me2K5-HIST2H3A [nucleoplasm] (R-HSA-1214225)	0.704	4
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.688	3
UniProt:Q16695 H3-4	3	Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186) HIST3H3 [nucleoplasm] (R-HSA-181914)	0.676	3
UniProt:Q12830-4 BPTF			0.675	16
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.667	4
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.662	5
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.623	2
UniProt:Q582G4 ANM7			0.618	4
UniProt:Q9BVI0 PHF20	3	p-S291-PHF20 [nucleoplasm] (R-HSA-6805776) p-S291-PHF20 [cytosol] (R-HSA-6805794) PHF20 [nucleoplasm] (R-HSA-3222239)	0.618	3
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.618	6
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.564	3
UniProt:Q8NCD3 HJURP	1	HJURP [nucleoplasm] (R-HSA-606331)	0.564	3
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.564	2
UniProt:Q9NVP2 ASF1B			0.564	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	3
UniProt:Q86UY6-1 NAA40			0.558	3
UniProt:P55201 BRPF1	1	BRPF1 [nucleoplasm] (R-HSA-3318466)	0.558	8
UniProt:A8MW92 P20L1			0.558	2
UniProt:P49450-1 CENPA			0.558	2
IntAct:EBI-9077146 7SK			0.558	2
UniProt:P25440 BRD2	1	BRD2 [nucleoplasm] (R-HSA-8951979)	0.558	5
UniProt:Q9VK33	2	Sfmbt [nucleoplasm] (R-DME-6804477) Sfmbt [nucleoplasm] (R-DME-6804480)	0.558	10
UniProt:P35609 ACTN2	3	ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [cytosol] (R-HSA-390562) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:Q05BQ5 MBTD1			0.544	3
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.544	2
UniProt:Q14684-1 RRP1B			0.537	3
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	5
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	3
UniProt:Q9UER7-1 DAXX			0.527	9
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.525	3
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.499	2
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.499	2
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.499	2
UniProt:C4QZQ7 C4QZQ7			0.495	2
UniProt:Q9UHJ3 SMBT1			0.462	2

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