SUMO1-HIST1H4 [nucleoplasm]

Stable Identifier
R-HSA-4570518
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H4, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P62805 H4C1
Gene Names
H4C1, H4/A, H4FA, HIST1H4A, H4C2, H4/I, H4FI, HIST1H4B, H4C3, H4/G, H4FG, HIST1H4C, H4C4, H4/B, H4FB, HIST1H4D, H4C5, H4/J, H4FJ, HIST1H4E, H4C6, H4/C, H4FC, HIST1H4F, H4C8, H4/H, H4FH, HIST1H4H, H4C9, H4/M, H4FM, HIST1H4I, H4C11, H4/E, H4FE, HIST1H4J, H4C12, H4/D, H4FD, HIST1H4K, H4C13, H4/K, H4FK, HIST1H4L, H4C14, H4/N, H4F2, H4FN, HIST2H4, HIST2H4A, H4C15, H4/O, H4FO, HIST2H4B, H4-16, HIST4H4
Chain
initiator methionine:1, chain:2-103
Reference Genes
BioGPS Gene:121504 H4C1
BioGPS Gene:554313 H4C1
BioGPS Gene:8294 H4C1
BioGPS Gene:8359 H4C1
BioGPS Gene:8360 H4C1
BioGPS Gene:8361 H4C1
BioGPS Gene:8362 H4C1
BioGPS Gene:8363 H4C1
BioGPS Gene:8364 H4C1
BioGPS Gene:8365 H4C1
BioGPS Gene:8366 H4C1
BioGPS Gene:8367 H4C1
BioGPS Gene:8368 H4C1
BioGPS Gene:8370 H4C1
CTD Gene:121504 H4C1
CTD Gene:554313 H4C1
CTD Gene:8294 H4C1
CTD Gene:8359 H4C1
CTD Gene:8360 H4C1
CTD Gene:8361 H4C1
CTD Gene:8362 H4C1
CTD Gene:8363 H4C1
CTD Gene:8364 H4C1
CTD Gene:8365 H4C1
CTD Gene:8366 H4C1
CTD Gene:8367 H4C1
CTD Gene:8368 H4C1
CTD Gene:8370 H4C1
dbSNP Gene:121504 H4C1
dbSNP Gene:554313 H4C1
dbSNP Gene:8294 H4C1
dbSNP Gene:8359 H4C1
dbSNP Gene:8360 H4C1
dbSNP Gene:8361 H4C1
dbSNP Gene:8362 H4C1
dbSNP Gene:8363 H4C1
dbSNP Gene:8364 H4C1
dbSNP Gene:8365 H4C1
dbSNP Gene:8366 H4C1
dbSNP Gene:8367 H4C1
dbSNP Gene:8368 H4C1
dbSNP Gene:8370 H4C1
ENSEMBL:ENSG00000158406 HIST1H4A
ENSEMBL:ENSG00000197061 HIST1H4A
ENSEMBL:ENSG00000197238 HIST1H4A
ENSEMBL:ENSG00000197837 HIST1H4A
ENSEMBL:ENSG00000270276 HIST1H4A
ENSEMBL:ENSG00000270882 HIST1H4A
ENSEMBL:ENSG00000273542 HIST1H4A
ENSEMBL:ENSG00000274618 HIST1H4A
ENSEMBL:ENSG00000275126 HIST1H4A
ENSEMBL:ENSG00000276180 HIST1H4A
ENSEMBL:ENSG00000276966 HIST1H4A
ENSEMBL:ENSG00000277157 HIST1H4A
ENSEMBL:ENSG00000278637 HIST1H4A
ENSEMBL:ENSG00000278705 HIST1H4A
HGNC:20510 H4C1
HGNC:29607 H4C1
HGNC:4781 H4C1
HGNC:4782 H4C1
HGNC:4783 H4C1
HGNC:4784 H4C1
HGNC:4785 H4C1
HGNC:4787 H4C1
HGNC:4788 H4C1
HGNC:4789 H4C1
HGNC:4790 H4C1
HGNC:4791 H4C1
HGNC:4793 H4C1
HGNC:4794 H4C1
KEGG Gene (Homo sapiens):121504 H4C1
KEGG Gene (Homo sapiens):554313 H4C1
KEGG Gene (Homo sapiens):8294 H4C1
KEGG Gene (Homo sapiens):8359 H4C1
KEGG Gene (Homo sapiens):8360 H4C1
KEGG Gene (Homo sapiens):8361 H4C1
KEGG Gene (Homo sapiens):8362 H4C1
KEGG Gene (Homo sapiens):8363 H4C1
KEGG Gene (Homo sapiens):8364 H4C1
KEGG Gene (Homo sapiens):8365 H4C1
KEGG Gene (Homo sapiens):8366 H4C1
KEGG Gene (Homo sapiens):8367 H4C1
KEGG Gene (Homo sapiens):8368 H4C1
KEGG Gene (Homo sapiens):8370 H4C1
Monarch:121504 H4C1
Monarch:554313 H4C1
Monarch:8294 H4C1
Monarch:8359 H4C1
Monarch:8360 H4C1
Monarch:8361 H4C1
Monarch:8362 H4C1
Monarch:8363 H4C1
Monarch:8364 H4C1
Monarch:8365 H4C1
Monarch:8366 H4C1
Monarch:8367 H4C1
Monarch:8368 H4C1
Monarch:8370 H4C1
NCBI Gene:121504 H4C1
NCBI Gene:554313 H4C1
NCBI Gene:8294 H4C1
NCBI Gene:8359 H4C1
NCBI Gene:8360 H4C1
NCBI Gene:8361 H4C1
NCBI Gene:8362 H4C1
NCBI Gene:8363 H4C1
NCBI Gene:8364 H4C1
NCBI Gene:8365 H4C1
NCBI Gene:8366 H4C1
NCBI Gene:8367 H4C1
NCBI Gene:8368 H4C1
NCBI Gene:8370 H4C1
OMIM:142750 H4C1
OMIM:602822 H4C1
OMIM:602823 H4C1
OMIM:602824 H4C1
OMIM:602825 H4C1
OMIM:602826 H4C1
OMIM:602827 H4C1
OMIM:602828 H4C1
OMIM:602829 H4C1
OMIM:602830 H4C1
OMIM:602831 H4C1
OMIM:602833 H4C1
OMIM:615069 H4C1
UCSC:P62805 H4C1
Reference Transcript
Other Identifiers
0001050411
0002190092
0002760136
0003140609
0003520324
0003610035
0003800215
0004010551
0004120750
0004570465
0005570082
0005570184
0006110717
11715116_s_at
11726245_s_at
11726246_x_at
11728049_s_at
11733368_at
11733369_x_at
11735753_at
11735775_at
11735776_x_at
11735942_at
11737314_at
11738060_s_at
11738103_at
11738601_at
11741794_s_at
11742669_s_at
11759221_at
121504
152_f_at
16670377
16692626
16761778
17005560
17005586
17005790
17005868
17016360
17016383
17016406
17016494
17016506
205967_at
206951_at
207046_at
208046_at
208076_at
208180_s_at
208580_x_at
214463_x_at
214516_at
214562_at
214634_at
232035_at
2357894
2357895
2357896
2357897
2357898
2357899
2357900
2357901
2357902
2357903
2357904
2357906
2357910
2434056
2434103
2434104
2434105
2434106
2434107
2434108
2434109
2434110
2434111
2434116
2899096
2899097
2899147
2899148
2899149
2899217
2899218
2899219
2899220
2899244
2899245
2899246
2899247
2899248
2899769
2899770
2899771
2900064
2900065
2946207
2946209
2946210
2946211
2946212
2946213
2946320
2946321
2946377
2946379
2946380
2946382
2946384
2946387
2946388
2946389
2947057
2947058
2947082
2947083
2947084
31521_f_at
31751_f_at
33049_at
34027_f_at
3445648
3445649
3445653
3445654
3445655
3445656
3445661
39969_at
50025_at
554313
57785_at
59154_at
762_f_at
7905067
7919627
7961483
81125_at
8117334
8117368
8117402
8117422
8117537
8117598
8124385
8124413
8124448
8124521
8124534
8180255
8180321
82468_at
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370
AB000905_at
ADDON000875.hg
ADDON001483.hg
ADDON002748.hg
ADDON002749.hg
ADDON002750.hg
ADDON002752.hg
ADDON002753.hg
ADDON002754.hg
ADDON002776.hg
ADDON002784.hg
ADDON002794.hg
ADDON002882.hg
A_14_P107645
A_14_P121153
A_14_P137590
A_21_P0014172
A_23_P214487
A_23_P30805
A_23_P30813
A_23_P323685
A_23_P359540
A_23_P388871
A_23_P395374
A_23_P415411
A_23_P431179
A_23_P436281
A_23_P70480
A_24_P166407
A_24_P20873
A_24_P261691
A_33_P3299865
A_33_P3344229
A_33_P3351851
A_33_P3410836
GE499003
GE501244
GE502647
GE506852
GE508495
GE572531
GE57844
GE58304
GE59861
GE79334
GE81299
GE81300
GE86856
GE87998
GO:0000183
GO:0000228
GO:0000278
GO:0000781
GO:0000786
GO:0002376
GO:0003674
GO:0003677
GO:0003723
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006302
GO:0006303
GO:0006334
GO:0006335
GO:0006336
GO:0006352
GO:0006950
GO:0007049
GO:0007059
GO:0007076
GO:0007165
GO:0008150
GO:0009058
GO:0016020
GO:0016233
GO:0019058
GO:0019904
GO:0022607
GO:0030154
GO:0032200
GO:0032991
GO:0034080
GO:0034641
GO:0042592
GO:0043226
GO:0044403
GO:0045007
GO:0045652
GO:0045653
GO:0045814
GO:0046982
GO:0048239
GO:0048856
GO:0051276
GO:0060765
GO:0060964
GO:0065003
GO:0070062
GO:0140014
GO:1900051
GO:1990000
HMNXSV003000546
HMNXSV003001014
HMNXSV003002656
HMNXSV003005824
HMNXSV003015566
HMNXSV003016171
HMNXSV003017340
HMNXSV003023270
HMNXSV003027409
HMNXSV003037762
HMNXSV003046538
HMNXSV003054339
HMNXSV003057871
Hs.131957.0.S1_3p_at
Hs.143080.0.S1_3p_at
Hs.248172.0.S2_3p_at
Hs.93758.1.S1_3p_at
Hs.93758.1.S1_3p_x_at
ILMN_1662359
ILMN_1670033
ILMN_1676580
ILMN_1681542
ILMN_1695199
ILMN_1698511
ILMN_1704284
ILMN_1708811
ILMN_1713436
ILMN_1723111
ILMN_1751120
ILMN_1777454
ILMN_1782329
ILMN_1797905
ILMN_2053992
ILMN_2075334
ILMN_2115340
ILMN_2119320
ILMN_2165369
ILMN_2224990
ILMN_3238233
M16707_rna1_at
M16707_rna1_s_at
PH_hs_0007863
PH_hs_0012922
PH_hs_0013176
PH_hs_0013177
PH_hs_0017043
PH_hs_0027130
PH_hs_0028888
PH_hs_0029036
PH_hs_0029514
PH_hs_0031203
PH_hs_0031792
PH_hs_0032299
PH_hs_0032446
PH_hs_0033270
PH_hs_0034759
PH_hs_0034804
TC01001173.hg
TC01003192.hg
TC06000163.hg
TC06000166.hg
TC06000172.hg
TC06000175.hg
TC06000224.hg
TC06000266.hg
TC06001341.hg
TC06001348.hg
TC06001355.hg
TC06001424.hg
TC06001428.hg
TC06002644.hg
TC12001272.hg
X00038_at
X60486_at
X60487_at
X67081_at
Z80787_at
g11415029_3p_x_at
g4504322_3p_at
g5579462_3p_at
g5579465_3p_at
g5579466_3p_a_at
g5579467_3p_at
Participates
as a component of
Other forms of this molecule
HIST1H4A [extracellular region]
SUMO3-HIST1H4 [nucleoplasm]
4xAcK-HIST1H4A [nucleoplasm]
AcK5,12-HIST1H4A [nucleoplasm]
AcK17-HIST1H4 [nucleoplasm]
AcK13-HIST1H4 [nucleoplasm]
AcK6-HIST1H4 [nucleoplasm]
AcK17-HIST1H4 [nucleoplasm]
AcK9-HIST1H4 [nucleoplasm]
Me2aR4-HIST1H4 [nucleoplasm]
Me2sR4-HIST1H4 [nucleoplasm]
MeR4-HIST1H4 [nucleoplasm]
Me3K21-HIST1H4 [nucleoplasm]
MeK21-HIST1H4 [nucleoplasm]
AcK-HIST1H4 [nucleoplasm]
MeK-HIST1H4A [nucleoplasm]
HIST1H4 [nucleoplasm]
Me2K21-HIST1H4 [nucleoplasm]
Inferred To
hhf3 [nucleoplasm] (Schizosaccharomyces pombe)
H4b [nucleoplasm] (Dictyostelium discoideum)
H4c11 [nucleoplasm] (Mus musculus)
SUMO1-HIST1H4 [nucleoplasm] (Plasmodium falciparum)
SUMO1-HIST1H4 [nucleoplasm] (Xenopus tropicalis)
H4-VI [nucleoplasm] (Gallus gallus)
his-56 [nucleoplasm] (Caenorhabditis elegans)
H4c2 [nucleoplasm] (Rattus norvegicus)
HHF2 [nucleoplasm] (Saccharomyces cerevisiae)
Modified Residues
Name
Inter-chain Crosslink via sumoylated lysine at unknown and 97
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
ZINC target
Ensembl
ENSP00000366974, ENST00000617569, ENST00000578186, ENST00000615164, ENST00000634956, ENST00000614247, ENSG00000277157, ENST00000615353, ENSP00000244537, ENSG00000274618, ENST00000377727, ENSG00000158406, ENST00000358064, ENST00000618305, ENSP00000350767, ENSG00000275126, ENST00000613412, ENSP00000481486, ENSP00000462667, ENST00000611927, ENSP00000479106, ENSG00000273542, ENSP00000481343, ENSP00000478519, ENST00000579512, ENSG00000278705, ENSG00000276180, ENSP00000489319, ENSP00000480960, ENSG00000197061, ENST00000377745, ENST00000614272, ENST00000618193, ENSP00000347168, ENSG00000197238, ENSP00000489567, ENST00000539745, ENSP00000479461, ENSP00000367034, ENSG00000197837, ENSG00000270882, ENST00000377803, ENST00000244537, ENSP00000462355, ENSP00000478786, ENSP00000479794, ENSP00000443017, ENSP00000484789, ENSP00000482412, ENSG00000278637, ENST00000355057, ENSP00000366956, ENSG00000270276, ENSP00000481507, ENST00000634560, ENST00000621520, ENST00000612061, ENSG00000276966
PRO
Pharos - Targets
Orphanet
GlyGen
PDB
7K60, 5GXQ, 2QQS, 3WA9, 6RNY, 4N3W, 6T79, 6V92, 6XJD, 3UW9, 4M38, 3X1U, 6INQ, 5BO0, 5BNX, 5B0Y, 5B40, 6M4H, 3AZN, 6M4G, 3X1V, 7C0M, 6R0C, 7K61, 6T7A, 6A5P, 7LMM, 6JOU, 6LAB, 4YYN, 6J50, 3AV1, 2RS9, 7JOA, 4Z5T, 6J51, 4YYM, 6L9Z, 6SEG, 3AV2, 5FA5, 6KE9, 5AVB, 6R92, 3QBY, 5Z23, 6R91, 6O1D, 2BQZ, 5AVC, 6IR9, 4H9O, 6A5L, 6KVD, 3W98, 3AZH, 3W97, 5Z30, 6A5O, 6JR0, 4QUU, 7K5Y, 5B33, 7LMK, 7K5X, 6M44, 5Y0D, 5FFW, 4H9S, 6USJ, 5BNV, 5B32, 3F9W, 3AZL, 5FWE, 5X7X, 5GT3, 7DBP, 3AZM, 6R90, 6R8Z, 6LA8, 6X59, 2KWO, 5KDM, 6M4D, 5TEG, 4YYK, 3WTP, 6HKT, 4YYJ, 6MLC, 3JPX, 6J4Z, 5XF5, 5AV9, 6FML, 3X1S, 3QZT, 5AV8, 6LA9, 6Y5D, 3CFV, 3QZV, 2IG0, 3F9Y, 3AFA, 6L9H, 4Z2M, 6SEF, 5XF4, 5GTC, 6J4Y, 7JZV, 7JO9, 6SEE, 3X1T, 4QUT, 6E0C, 3W96, 6T93, 7A08, 3AZF, 3F9Z, 3AZG, 4YY6, 4YM5, 4H9N, 4H9Q, 3W99, 3AZJ, 6V2K, 5CPJ, 4GQB, 5B31, 6L4A, 6YOV, 3AZK, 7CCR, 6M3V, 2CV5, 5C3I, 4H9R, 6R8Y, 6LA2, 7BY0, 4YYI, 6T7D, 6J4W, 6KXV, 2KWN, 3O36, 4YYH, 5JRG, 6UPL, 5AY8, 5AV6, 7D1Z, 6SE6, 5B2J, 5GT0, 7D20, 6SE0, 5AV5, 5GSE, 2RNY, 4HGA, 1ZKK, 3QZS, 6K1J, 6MUP, 6J4X, 6RXS, 5XF3, 2LVM, 3AYW, 3CFS, 6A5U, 3F9X, 3IJ1, 3AZE, 6X5A, 6LER, 5ZGC, 5Y0C, 3R45, 3A6N, 6K1K, 6T90, 3UVY, 5GSU, 3UVX, 5B2I, 3AZI, 5YE4, 3WAA, 5CPI, 4H9P, 4YM6, 3WKJ, 6C0W, 5YE3, 4YYG, 6HTS, 4N4F, 6L49, 6E0P, 4YYD, 6A5R, 6BUZ, 7BXT, 3NQU, 6T7C, 4U9W, 7K63, 6T7B, 6UPK, 5B0Z, 6K1I, 3AN2, 6R94, 6LE9, 6MUO, 6R93, 5CPK, 6A5T, 6VO5, 5B24, 3NQJ, 7CCQ, 6JR1, 5JA4, 3UVW, 6ACP, 2RJE, 4QYD, 5ZBX
Interactors (64)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9Y294 ASF1A  1 0.951 15
 UniProt:P68431 H3C1  20 0.891 7
 UniProt:Q12888 TP53BP1  3 0.87 14
 UniProt:P84243 H3-3A  15 0.861 12
 UniProt:P04908 H2AC4  13 0.835 11
 UniProt:P16104 H2AX  7 0.802 5
 UniProt:P49450 CENPA  2 0.793 6
 UniProt:Q16576 RBBP7  1 0.793 9
 UniProt:Q9NQR1 KMT5A  1 0.775 6
 UniProt:O14744 PRMT5  3 0.756 6
 UniProt:P49736 MCM2  1 0.748 9
 UniProt:O75164 KDM4A  2 0.743 7
 UniProt:O60885-1 BRD4      0.739 10
 IntAct:EBI-10097414 FOXP3      0.725 4
 UniProt:Q12888-1 TP53BP1      0.722 3
 UniProt:O14929 HAT1  1 0.704 7
 UniProt:Q71DI3 H3C15  20 0.704 4
 UniProt:Q13547 HDAC1  2 0.688 3
 UniProt:Q92993 KAT5  1 0.683 4
 UniProt:Q16695 H3-4  3 0.676 3
 UniProt:Q12830-4 BPTF      0.675 16
 UniProt:P45973 CBX5  2 0.669 3
 UniProt:Q9NVP2 ASF1B      0.669 4
 UniProt:Q9UER7 DAXX  13 0.669 4
 UniProt:Q9Y468 L3MBTL1  1 0.667 4
 UniProt:Q15672 TWIST1  1 0.662 5
 UniProt:Q99873 PRMT1  2 0.623 2
 UniProt:Q9BVI0 PHF20  3 0.618 3
 UniProt:Q582G4 ANM7      0.618 4
 UniProt:Q92793 CREBBP  3 0.618 6
 UniProt:Q8NCD3 HJURP  1 0.564 3
 UniProt:P63104 YWHAZ  2 0.564 3
 UniProt:Q86UY6-1 NAA40      0.558 3
 UniProt:P55201 BRPF1  1 0.558 8
 UniProt:A8MW92 P20L1      0.558 2
 UniProt:P49450-1 CENPA      0.558 2
 IntAct:EBI-9077146 7SK      0.558 2
 UniProt:P25440 BRD2  1 0.558 5
 UniProt:Q9VK33  2 0.558 10
 UniProt:P35609 ACTN2  3 0.556 3
 UniProt:Q8TAP4-4 LMO3      0.556 3
 UniProt:P61981 YWHAG  1 0.556 3
 UniProt:Q15047-2 SETDB1      0.556 3
 UniProt:Q8IUQ4 SIAH1  1 0.556 3
 UniProt:P17252 PRKCA  8 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:O60264 SMARCA5  1 0.544 2
 UniProt:Q05BQ5 MBTD1      0.544 3
 UniProt:Q14684-1 RRP1B      0.537 3
 UniProt:P33993 MCM7  1 0.527 3
 UniProt:Q92731 ESR2  5 0.527 5
 UniProt:P33991 MCM4  1 0.527 3
 UniProt:Q9UER7-1 DAXX      0.527 9
 UniProt:Q13112 CAF1B      0.527 2
 UniProt:Q14566 MCM6  1 0.527 3
 UniProt:P83916 CBX1  1 0.527 2
 UniProt:Q13185 CBX3  1 0.527 2
 UniProt:P62993 GRB2  1 0.527 2
 UniProt:Q9NQ92 COPRS  1 0.525 3
 UniProt:P33992 MCM5  1 0.499 2
 UniProt:Q09028 RBBP4  1 0.499 2
 UniProt:P25205 MCM3  1 0.499 2
 UniProt:C4QZQ7 C4QZQ7      0.495 2
 UniProt:Q9UHJ3 SMBT1      0.462 2
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