Reactome | TJP2 [plasma membrane]

TJP2 [plasma membrane]

Stable Identifier

R-HSA-351862

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ZO-2, Zonula occludens protein 2, Tight junction protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UDY2 TJP2

Gene Names

TJP2, X104, ZO2

Chain

chain:1-1190

Reference Genes

BioGPS Gene:9414 TJP2

COSMIC (genes):TJP2 TJP2

CTD Gene:9414 TJP2

dbSNP Gene:9414 TJP2

ENSEMBL:ENSG00000119139 TJP2

HGNC:11828 TJP2

KEGG:hsa:9414 TJP2

Monarch:9414 TJP2

NCBI Gene:9414 TJP2

OMIM:607709 TJP2

UCSC:Q9UDY2 TJP2

Reference Transcript

Other Identifiers

11716742_a_at

11716743_s_at

11716744_x_at

11745848_a_at

11751951_a_at

11756897_x_at

11763304_at

17085685

202085_PM_at

202085_at

232017_PM_at

232017_at

237132_PM_at

237132_at

242991_PM_at

242991_at

3173881

3173882

3173883

3173884

3173885

3173886

3173887

3173888

3173889

3173890

3173891

3173892

3173893

3173894

3173895

3173896

3173897

3173898

3173900

3173901

3173902

3173903

3173904

3173905

3173906

3173907

3173908

3173909

3173910

3173911

3173912

3173913

3173914

3173915

3173916

3173917

3173919

3173920

3173921

3173922

3173923

3173924

3173925

3173926

3173927

3173928

3173929

3173942

3173943

3173962

3173967

3173969

36655_at

50087_at

54505_at

71323_r_at

8155707

9414

A_14_P139168

A_23_P9293

A_24_P201153

A_33_P3215527

A_33_P3215529

A_33_P3282963

GE57705

GO:0003013

GO:0003824

GO:0004385

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005912

GO:0005923

GO:0007155

GO:0016740

GO:0019904

GO:0022600

GO:0030674

GO:0034109

GO:0034330

GO:0035633

GO:0043226

GO:0044291

GO:0044325

GO:0045216

GO:0045296

GO:0046037

GO:0046710

GO:0048856

GO:0050839

GO:0050892

GO:0055086

GO:0060090

GO:0070160

GO:0090557

GO:0090559

GO:0098609

GO:0150105

GO:1901135

GO:1905605

GO:1990782

HMNXSV003002300

HMNXSV003007454

HMNXSV003022400

HMNXSV003023127

Hs.213904.0.A1_3p_at

Hs.26402.0.A1_3p_at

Hs.289005.0.S1_3p_at

ILMN_1652151

ILMN_1664978

ILMN_1763972

ILMN_2384561

L27476_at

PH_hs_0004346

TC09000319.hg

TC09001995.hg

TC09001996.hg

g4759341_3p_at

p16793

Participates

as a candidate of

as an input of

Caspase-mediated cleavage of Z0-2 (Homo sapiens)

Other forms of this molecule

TJP2(?-?) [plasma membrane]

TJP2 [cytosol]

TJP2 [nucleoplasm]

Inferred To

pyd [plasma membrane] (Drosophila melanogaster)

Tjp2 [plasma membrane] (Mus musculus)

Tjp2 [plasma membrane] (Rattus norvegicus)

zoo-1 [plasma membrane] (Caenorhabditis elegans)

tjp2 [plasma membrane] (Xenopus tropicalis)

TJP2 [plasma membrane] (Bos taurus)

TJP2 [plasma membrane] (Canis familiaris)

TJP2 [plasma membrane] (Gallus gallus)

TJP2 [plasma membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000119139

ENSEMBL

ENSP00000438262, ENST00000535702, ENST00000348208, ENSP00000345893, ENST00000377245, ENSP00000442090, ENSP00000366453, ENSG00000119139, ENST00000539225

HPA

ENSG00000119139-TJP2

GeneCards

TJP2

PRO

Q9UDY2

Pharos - Targets

Q9UDY2

Orphanet

TJP2

GlyGen

Q9UDY2

PDB

3E17, 2OSG

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.862	7
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.714	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.688	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.671	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.589	2
UniProt:Q14847 LASP1			0.584	9
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	3
UniProt:Q15058 KIF14	1	KIF14 [cytosol] (R-HSA-1629804)	0.483	2
UniProt:Q07157 TJP1	5	TJP1 [cytosol] (R-HSA-532659) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [cell junction] (R-HSA-8936023)	0.483	3
UniProt:Q9NQT4 EXOSC5	3	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [nucleolus] (R-HSA-9935829)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	13
UniProt:Q66GS9 CEP135	1	CEP135 [cytosol] (R-HSA-380266)	0.483	3
UniProt:Q96HS1 PGAM5			0.483	2