Reactome | TJP2 [plasma membrane]

TJP2 [plasma membrane]

Stable Identifier

R-HSA-351862

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ZO-2, Zonula occludens protein 2, Tight junction protein 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UDY2 TJP2

Gene Names

TJP2, X104, ZO2

Chain

chain:1-1190

Reference Genes

BioGPS Gene:9414 TJP2

COSMIC (genes):TJP2 TJP2

CTD Gene:9414 TJP2

dbSNP Gene:9414 TJP2

ENSEMBL:ENSG00000119139 TJP2

ENSEMBL:ENSG00000119139.21 TJP2

HGNC:11828 TJP2

KEGG Gene (Homo sapiens):9414 TJP2

Monarch:9414 TJP2

NCBI Gene:9414 TJP2

OMIM:607709 TJP2

UCSC:Q9UDY2 TJP2

Reference Transcript

Other Identifiers

11716742_a_at

11716743_s_at

11716744_x_at

11745848_a_at

11751951_a_at

11756897_x_at

17085685

202085_PM_at

202085_at

3173886

3173887

3173888

3173889

3173890

3173892

3173893

3173895

3173896

3173897

3173898

3173900

3173901

3173902

3173903

3173904

3173905

3173906

3173908

3173911

3173912

3173916

3173919

3173920

3173921

3173922

3173927

3173928

3173929

36655_at

8155707

9414

A_23_P9293

GE57705

GO:0003013

GO:0003824

GO:0004385

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005912

GO:0005923

GO:0007155

GO:0010033

GO:0016020

GO:0016740

GO:0019904

GO:0022600

GO:0030154

GO:0030674

GO:0034109

GO:0034330

GO:0035633

GO:0043226

GO:0044291

GO:0044325

GO:0045216

GO:0045296

GO:0046037

GO:0046710

GO:0048856

GO:0050839

GO:0050892

GO:0055086

GO:0060090

GO:0070160

GO:0070161

GO:0090557

GO:0090559

GO:0098609

GO:0150105

GO:1901135

GO:1905605

GO:1990782

HMNXSV003022400

HMNXSV003023127

ILMN_1664978

ILMN_1763972

ILMN_2384561

L27476_at

PH_hs_0004346

TC09001995.hg

TC09001996.hg

g4759341_3p_at

Participates

as a candidate of

as an input of

Caspase-mediated cleavage of Z0-2 (Homo sapiens)

Other forms of this molecule

TJP2 [cytosol]

TJP2 [nucleoplasm]

TJP2(?-?) [plasma membrane]

Inferred To

tjp2.1 [plasma membrane] (Danio rerio)

pyd [plasma membrane] (Drosophila melanogaster)

Tjp2 [plasma membrane] (Mus musculus)

Tjp2 [plasma membrane] (Rattus norvegicus)

zoo-1 [plasma membrane] (Caenorhabditis elegans)

tjp2 [plasma membrane] (Xenopus tropicalis)

TJP2 [plasma membrane] (Bos taurus)

TJP2 [plasma membrane] (Canis familiaris)

TJP2 [plasma membrane] (Gallus gallus)

TJP2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_011517511.1, XP_011517508.1, XP_011517509.1, NP_004808.2, NP_001163887.1, NP_001163886.1, XP_011517510.1

OpenTargets

ENSG00000119139

HPA

ENSG00000119139-TJP2

GeneCards

Q9UDY2

Ensembl

ENSP00000438262, ENSP00000345893, ENST00000348208, ENST00000535702, ENSG00000119139, ENST00000539225, ENSP00000366453, ENSP00000442090, ENST00000377245

PRO

Q9UDY2

Pharos - Targets

Q9UDY2

Orphanet

19466

PDB

2OSG, 3E17

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.688	3
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.625	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.589	2
UniProt:Q14847 LASP1			0.584	9
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	13

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