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SMARCA5 [nucleoplasm]
Stable Identifier
R-HSA-417140
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, SNF2H, SMCA5_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Nucleosome assembly (Homo sapiens)
Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
RSF complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Homo sapiens)
RSF Complex [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
RSF Complex [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
WICH phosphorylates H2AFX on Y142 (Homo sapiens)
WICH [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
NoRC [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
NoRC [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
NoRC [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
NoRC [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
B-WICH complex positively regulates rRNA expression (Homo sapiens)
B-WICH complex binds rDNA promoter (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
B-WICH [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
B-WICH recruits histone acetyltransferases (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
B-WICH [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
B-WICH [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
B-WICH [nucleoplasm] (Homo sapiens)
SMARCA5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60264 SMARCA5
Gene Names
SMARCA5, SNF2H, WCRF135
Chain
initiator methionine:, chain:2-1052
Reference Genes
BioGPS Gene:8467 SMARCA5
COSMIC (genes):SMARCA5 SMARCA5
CTD Gene:8467 SMARCA5
dbSNP Gene:8467 SMARCA5
ENSEMBL:ENSG00000153147 SMARCA5
ENSEMBL_homo_sapiens_GENE:ENSG00000153147.6 SMARCA5
HGNC:11101 SMARCA5
KEGG Gene (Homo sapiens):8467 SMARCA5
Monarch:8467 SMARCA5
NCBI Gene:8467 SMARCA5
OMIM:603375 SMARCA5
UCSC:O60264 SMARCA5
Reference Transcript
RefSeq:NM_003601.3 SMARCA5
Other Identifiers
11718423_a_at
11764117_s_at
16971048
16971078
202303_PM_x_at
202303_x_at
213251_PM_at
213251_at
213859_PM_x_at
213859_x_at
240063_PM_at
240063_at
2745658
2745659
2745660
2745661
2745662
2745667
2745670
2745671
2745673
2745674
2745675
2745676
2745677
2745678
2745680
2745682
2745683
2745684
2745686
2745687
2745689
2745690
2745691
2745692
2745693
2745694
2745695
2745699
2745700
2745701
2745702
2745703
2745704
2745705
2745709
2745711
2745713
2745714
2745715
2745716
2745717
2745718
2745719
2745720
3053729
3709817
39132_at
75093_at
77754_at
8097600
8097626
8467
ADDON000038.hg
A_14_P201342
A_21_P0012750
A_23_P256716
A_23_P406591
A_32_P213678
GE578024
GE79039
GO:0000166
GO:0000183
GO:0000228
GO:0000278
GO:0000793
GO:0001650
GO:0003677
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005721
GO:0005730
GO:0006260
GO:0006275
GO:0006281
GO:0006325
GO:0006334
GO:0006338
GO:0006351
GO:0006352
GO:0006355
GO:0006357
GO:0006974
GO:0007059
GO:0008094
GO:0008623
GO:0016479
GO:0016589
GO:0016590
GO:0016787
GO:0016887
GO:0031010
GO:0031062
GO:0031065
GO:0031213
GO:0031491
GO:0031507
GO:0035066
GO:0035861
GO:0036211
GO:0042393
GO:0043226
GO:0043596
GO:0044030
GO:0045740
GO:0045893
GO:0045943
GO:0045944
GO:0045945
GO:0065003
GO:0090535
GO:0090536
GO:0110016
GO:0140014
GO:0140097
GO:0140657
GO:0140658
GO:0140751
GO:1905213
GO:1990830
HMNXSV003025925
HMNXSV003049298
Hs.130269.0.A1_3p_at
Hs.9456.1.A1_3p_a_at
Hs.9456.1.A1_3p_x_at
Hs.9456.2.A1_3p_at
ILMN_1693523
ILMN_1713163
ILMN_2223130
PH_hs_0022544
PH_hs_0036972
TC04000701.hg
TC04000702.hg
g4507074_3p_a_at
p34048
p34275
Participates
as a component of
NoRC [nucleoplasm] (Homo sapiens)
B-WICH [nucleoplasm] (Homo sapiens)
RSF Complex [nucleoplasm] (Homo sapiens)
WICH [nucleoplasm] (Homo sapiens)
as an input of
B-WICH complex binds rDNA promoter (Homo sapiens)
Inferred To
Smarca5 [nucleoplasm]
(Rattus norvegicus)
isw [nucleoplasm]
(Dictyostelium discoideum)
SMARCA5 [nucleoplasm]
(Bos taurus)
SMARCA5 [nucleoplasm]
(Caenorhabditis elegans)
SMARCA5 [nucleoplasm]
(Canis familiaris)
SMARCA5 [nucleoplasm]
(Drosophila melanogaster)
SMARCA5 [nucleoplasm]
(Gallus gallus)
SMARCA5 [nucleoplasm]
(Mus musculus)
SMARCA5 [nucleoplasm]
(Plasmodium falciparum)
SMARCA5 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_003592.3
OpenTargets
ENSG00000153147
GeneCards
O60264
HPA
ENSG00000153147-SMARCA5
Ensembl
ENSG00000153147
,
ENSP00000283131
,
ENST00000283131
PRO
O60264
Pharos - Targets
O60264
Orphanet
22572
PDB
8V7L
,
6NE3
,
8V4Y
,
8V6V
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UIG0 BAZ1B
1
BAZ1B [nucleoplasm]
(R-HSA-417153)
0.81
8
UniProt:Q9NRL2 BAZ1A
0.723
4
UniProt:Q96T23 RSF1
1
RSF1 [nucleoplasm]
(R-HSA-606345)
0.675
6
UniProt:Q12830 BPTF
0.564
2
IntAct:EBI-22235520 SHDAG
0.558
3
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.544
2
UniProt:Q9C005 DPY30
1
DPY30 [nucleoplasm]
(R-HSA-5669104)
0.527
2
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.527
5
UniProt:Q8IXM2 BAP18
0.527
2
UniProt:Q9NRF9 POLE3
1
POLE3 [nucleoplasm]
(R-HSA-8866685)
0.527
3
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.527
3
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.527
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.462
2
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