Reactome | RIPK1 D324Y [cytosol]

RIPK1 D324Y [cytosol]

Stable Identifier

R-HSA-9693931

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Receptor-interacting serine/threonine-protein kinase 1 D324Y, receptor interacting protein 1 kinase D324Y, RIP1 D324Y

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Literature References

PubMed ID	Title	Journal	Year
31827281	Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease Stoffels, M, Light, A, Voss, AK, Kratina, T, Yang, D, Hawkins, ED, Lalaoui, N, Gutierrez-Cruz, G, Kastner, DL, Liu, L, Moura, NS, Kuehn, HS, Ombrello, AK, Zhou, Q, Lawlor, KE, Wachsmuth, L, Mullikin, JC, Zaal, KJM, Kueh, AJ, Lenardo, MJ, Silke, N, Gadina, M, Boehm, M, Zheng, L, Chau, D, Pinto-Patarroyo, GP, Shield-Artin, K, Wood, GM, Anderton, H, Hall, C, Chae, JJ, Hoffmann, PM, Aksentijevich, I, Rosenzweig, SD, Pasparakis, M, Jones, A, Boyden, SE, Wang, H, Dmitrieva, NI, Tsai, WL, Gross, AJ, Biben, C, Romeo, TM, Etemadi, N, Blake, MD, Masters, SL, Barham, BK, Silke, J, Shum, AK, McKenzie, M, Herold, MJ, Stone, DL, Oda, H, Beck, DB	Nature	2020

External Reference Information

External Reference

UniProt:Q13546 RIPK1

Gene Names

RIPK1, RIP, RIP1

Chain

chain:1-671

Reference Genes

BioGPS Gene:8737 RIPK1

COSMIC (genes):RIPK1 RIPK1

CTD Gene:8737 RIPK1

dbSNP Gene:8737 RIPK1

ENSEMBL:ENSG00000137275 RIPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000137275.16 RIPK1

HGNC:10019 RIPK1

KEGG Gene (Homo sapiens):8737 RIPK1

Monarch:8737 RIPK1

NCBI Gene:8737 RIPK1

OMIM:603453 RIPK1

UCSC:Q13546 RIPK1

Reference Transcript

Other Identifiers

11737938_a_at

11737939_a_at

11737940_s_at

11750849_a_at

11756807_a_at

17004295

209941_PM_at

209941_at

226551_PM_at

226551_at

2892343

2892344

2892345

2892349

2892350

2892352

2892355

2892356

2892357

2892358

2892359

2892363

2892364

2892372

2892373

2892375

2892376

2892377

2892378

2892379

2892383

2892385

2892386

2892387

2892388

2892389

2939062

2939063

40696_at

475_at

51161_at

8116622

8737

A_23_P370005

A_33_P3279059

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004706

GO:0005123

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006950

GO:0006954

GO:0006979

GO:0007165

GO:0008152

GO:0010008

GO:0010628

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0031047

GO:0031264

GO:0031349

GO:0031410

GO:0031625

GO:0032103

GO:0032757

GO:0032760

GO:0032991

GO:0033209

GO:0034612

GO:0035556

GO:0035591

GO:0036211

GO:0036289

GO:0042327

GO:0042802

GO:0042803

GO:0043065

GO:0043066

GO:0043068

GO:0043123

GO:0043124

GO:0043226

GO:0043235

GO:0043410

GO:0043525

GO:0044877

GO:0045651

GO:0045944

GO:0046330

GO:0046777

GO:0048856

GO:0050729

GO:0051092

GO:0055085

GO:0060090

GO:0060545

GO:0060546

GO:0062100

GO:0065003

GO:0070105

GO:0070231

GO:0070266

GO:0070301

GO:0070513

GO:0070926

GO:0071345

GO:0071356

GO:0071363

GO:0097191

GO:0097300

GO:0097342

GO:0097343

GO:0097527

GO:0106310

GO:0140096

GO:1900119

GO:1901026

GO:1901224

GO:1903265

GO:1903800

GO:1990000

GO:2000377

GO:2000379

GO:2001237

GO:2001238

GO:2001240

HMNXSV003025407

HMNXSV003028067

Hs.77273.1.A1_3p_at

Hs.77273.1.A1_3p_x_at

ILMN_2119535

PH_hs_0018906

TC06000023.hg

TC06002463.hg

U50062_at

g3426026_3p_at

Participates

as a member of

non-cleavable RIPK1 variants [cytosol] (Homo sapiens)

Other forms of this molecule

K48polyUb-RIPK1 [cytosol]

PolyUb-RIPK1 [cytosol]

RIPK1 D324N [cytosol]

RIPK1 D324V [cytosol]

RIPK1 D324H [cytosol]

RIPK1 [plasma membrane]

K48polyUb-K571,K604,K627-RIPK1 [cytosol]

K63,Met1polyUb-p-S25-RIPK1 [cytosol]

K63,M1polyUb-RIPK1 [cytosol]

RIPK1(1-324) [cytosol]

RIPK1(325-671) [cytosol]

polyUb-K377,K604,K634-RIPK1 [cytosol]

K63,M1polyUb, p-T189-RIPK1 [cytosol]

p-S320-RIPK1 [cytosol]

p-S357-RIPK1 [cytosol]

p-S166-RIPK1 [cytosol]

K63polyUb-RIPK1 [cytosol]

RIPK1 [endosome membrane]

RIPK1 [cytosol]

Modified Residues

Name

L-aspartic acid 324 replaced with L-tyrosine

Coordinate

324

PsiMod

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

L-tyrosine residue

A protein modification that effectively converts a source amino acid residue to L-tyrosine.

Disease

Name	Identifier	Synonyms
genetic disease	DOID:630

Cross References

RefSeq

XP_005249514.2, NP_003795.2

ZINC - World Drugs

RIPK1_HUMAN

Guide to Pharmacology - Targets

2189

OpenTargets

ENSG00000137275

ZINC - FDA approved

RIPK1_HUMAN

ZINC - Substances

RIPK1_HUMAN

ZINC target

Q13546

PRO

Q13546

PDB

7CJB, 5HX6, 5V7Z, 6HHO, 4ITJ, 4NEU, 6C3E, 6NW2, 7XMK, 5TX5, 8I2N, 6R5F, 7FCZ, 6NYH, 6RLN, 7YDX, 4ITH, 6C4D, 4ITI, 6AC5, 6OCQ, 7FD0

ZINC - Investigational

RIPK1_HUMAN

HPA

ENSG00000137275-RIPK1

GeneCards

Q13546

Ensembl

ENST00000259808, ENSP00000259808, ENST00000380409, ENSP00000369773, ENSG00000137275

Pharos - Targets

Q13546

ZINC - Predictions - Purchasable

RIPK1_HUMAN

HMDB Protein

HMDBP09499

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y572 RIPK3	8	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825)	0.972	27
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.959	30
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.928	12
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.893	9
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.892	11
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.884	10
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.877	7
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.837	9
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.798	8
UniProt:P0DTD1-PRO_0000449629 REP			0.788	6
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.703	5
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.697	5
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.602	5
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	2
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.564	3
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.556	5
IntAct:EBI-4399559 UBIQ			0.544	3
UniProt:Q13107 USP4	1	USP4 [cytosol] (R-HSA-5212663)	0.524	4
UniProt:Q8IVM0 CCD50			0.524	2
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.508	2
UniProt:B7UI21 NLEB1			0.508	4
UniProt:U5TQE9 U5TQE9			0.499	3
UniProt:Q96AB6 NTAN1			0.499	2

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