Reactome | p-T183-STK4(1-487) [cytosol]

p-T183-STK4(1-487) [cytosol]

Stable Identifier

R-HSA-2028258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T183-STK4, p-STK4, phosphorylated Serine/threonine-protein kinase 4, p-MST1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13043 STK4

Gene Names

STK4, KRS2, MST1

Chain

chain:1-487, chain:1-326, chain:327-487

Reference Genes

BioGPS Gene:6789 STK4

COSMIC (genes):STK4 STK4

CTD Gene:6789 STK4

dbSNP Gene:6789 STK4

ENSEMBL:ENSG00000101109 STK4

ENSEMBL:ENSG00000101109.13 STK4

HGNC:11408 STK4

KEGG Gene (Homo sapiens):6789 STK4

Monarch:6789 STK4

NCBI Gene:6789 STK4

OMIM:604965 STK4

UCSC:Q13043 STK4

Reference Transcript

Other Identifiers

11723400_a_at

11723401_x_at

11723402_a_at

11750551_a_at

11756934_a_at

16914147

205411_PM_at

205411_at

211085_PM_s_at

211085_s_at

225364_PM_at

225364_at

236259_PM_at

236259_at

36294_at

3886705

3886706

3886707

3886710

3886718

3886720

3886722

3886724

3886725

3886727

3886728

3886732

3886738

3886743

3886744

3886745

3886746

3886747

3886749

3886751

53858_at

59278_at

6789

77474_at

8062908

A_14_P120879

A_23_P143199

A_24_P185615

A_24_P94054

A_33_P3222648

GE511474

GE705798

GE81616

GE86072

GO:0000166

GO:0000287

GO:0000902

GO:0001569

GO:0001841

GO:0001934

GO:0002376

GO:0003157

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0006606

GO:0006886

GO:0006913

GO:0006915

GO:0007155

GO:0007165

GO:0007417

GO:0008283

GO:0008285

GO:0008625

GO:0012501

GO:0016301

GO:0016310

GO:0016604

GO:0016740

GO:0018105

GO:0022414

GO:0023052

GO:0030154

GO:0030216

GO:0032092

GO:0032991

GO:0033138

GO:0035265

GO:0035329

GO:0035556

GO:0036211

GO:0042802

GO:0042803

GO:0043065

GO:0043226

GO:0043408

GO:0043539

GO:0045600

GO:0046621

GO:0046777

GO:0046872

GO:0048856

GO:0048870

GO:0050673

GO:0050680

GO:0050821

GO:0051262

GO:0060070

GO:0060215

GO:0060706

GO:0060800

GO:0061629

GO:0065003

GO:0090090

GO:0097284

GO:0098772

GO:0106310

GO:0140096

GO:1902043

GO:1903945

GO:1904237

HMNXSV003045854

HMNXSV003047655

Hs.250824.0.S1_3p_at

Hs.268051.0.A1_3p_at

ILMN_1711383

PH_hs_0002864

TC20000339.hg

TC20001234.hg

U18297_s_at

g405738_3p_s_at

g5454095_3p_at

Participates

as a component of

p-STK4 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

p-T183-STK4(1-326) [cytosol]

STK4(327-487) [cytosol]

STK4(1-487) [cytosol]

Inferred To

Homologues of p-T183-STK4(1-487) [cytosol] (Caenorhabditis elegans)

phospho-STK4 [cytosol] (Gallus gallus)

phospho-p-T183-STK4(1-487) [cytosol] (Bos taurus)

phospho-p-T183-STK4(1-487) [cytosol] (Caenorhabditis elegans)

phospho-p-T183-STK4(1-487) [cytosol] (Canis familiaris)

phospho-p-T183-STK4(1-487) [cytosol] (Drosophila melanogaster)

phospho-p-T183-STK4(1-487) [cytosol] (Mus musculus)

phospho-p-T183-STK4(1-487) [cytosol] (Rattus norvegicus)

phospho-p-T183-STK4(1-487) [cytosol] (Sus scrofa)

phospho-p-T183-STK4(1-487) [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 183

Coordinate

183

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005260590.1, NP_006273.1

ZINC - World Drugs

STK4_HUMAN

Guide to Pharmacology - Targets

2225

OpenTargets

ENSG00000101109

ZINC - FDA approved

STK4_HUMAN

ZINC - Substances

STK4_HUMAN

ZINC target

Q13043

ZINC - Biogenic

STK4_HUMAN

PRO

Q13043

PDB

5TWG, 4OH8, 2JO8, 8A5J, 6YAT, 5TWH, 4NR2, 3COM

ZINC - Investigational

STK4_HUMAN

HPA

ENSG00000101109-STK4

GeneCards

Q13043

Ensembl

ENSP00000361887, ENST00000372806, ENSG00000101109, ENSP00000361892, ENST00000372801

Pharos - Targets

Q13043

Orphanet

21606

ZINC - Predictions - Purchasable

STK4_HUMAN

HMDB Protein

HMDBP01490

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.937	20
UniProt:P50749 RASF2			0.91	16
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(1-491) [cytosol] (R-HSA-2028280)	0.904	19
UniProt:Q8WWW0 RASF5			0.84	8
UniProt:Q9NS23 RASF1			0.827	8
UniProt:Q9H2L5 RASF4			0.779	6
UniProt:Q86WH2 RASF3			0.772	6
UniProt:Q9H8S9 MOB1A	2	p-T12,T35-MOB1A [cytosol] (R-HSA-2028628) MOB1A [cytosol] (R-HSA-2028568)	0.747	9
UniProt:Q9NS23-2 RASSF1			0.729	4
UniProt:Q14BN4 SLMAP			0.726	7
UniProt:Q13043 STK4	4	p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) STK4(327-487) [cytosol] (R-HSA-2028668) STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258)	0.678	4
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.66	11
UniProt:P46821 MAP1B			0.643	3
UniProt:Q6ZTQ3 RASF6			0.632	4
UniProt:Q7L9L4 MOB1B	2	p-T12,T35-MOB1B [cytosol] (R-HSA-2028643) MOB1B [cytosol] (R-HSA-2028569)	0.629	4
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.619	13
UniProt:Q66K74 MAP1S			0.615	4
UniProt:P35700 Prdx1	3	p-T90-Prdx1 [cytosol] (R-MMU-8868582) Prdx1 [cytosol] (R-MMU-5629198) Prdx1 [cytosol] (R-MMU-8868585)	0.611	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.591	7
UniProt:Q8WWW0-2 RASSF5			0.581	4
UniProt:Q99MK9 RASF1			0.564	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.544	2
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.544	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.544	2
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.527	2
UniProt:Q91VJ4	1	STK38 [cytosol] (R-MMU-9715143)	0.525	2
UniProt:Q8WWW0-3 RASSF5			0.508	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.483	3

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