Reactome | DYNC1H1 [azurophil granule lumen]

DYNC1H1 [azurophil granule lumen]

Stable Identifier

R-HSA-6799155

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

cytoplasmic dynein 1 heavy chain 1

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External Reference Information

External Reference

UniProt:Q14204 DYNC1H1

Gene Names

DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325

Chain

initiator methionine:, chain:2-4646

Reference Genes

BioGPS Gene:1778 DYNC1H1

COSMIC (genes):DYNC1H1 DYNC1H1

CTD Gene:1778 DYNC1H1

dbSNP Gene:1778 DYNC1H1

ENSEMBL:ENSG00000197102 DYNC1H1

ENSEMBL_homo_sapiens_GENE:ENSG00000197102.14 DYNC1H1

HGNC:2961 DYNC1H1

KEGG Gene (Homo sapiens):1778 DYNC1H1

Monarch:1778 DYNC1H1

NCBI Gene:1778 DYNC1H1

OMIM:600112 DYNC1H1

UCSC:Q14204 DYNC1H1

Reference Transcript

RefSeq:NM_001376.4 DYNC1H1

Other Identifiers

11715589_at

11715590_at

11715591_s_at

11715592_x_at

16788883

1778

211928_PM_at

211928_at

229115_PM_at

229115_at

241084_PM_x_at

241084_x_at

244768_PM_at

244768_at

3107195

3552855

3552861

3552862

3552863

3552864

3552865

3552866

3552867

3552868

3552869

3552870

3552872

3552873

3552874

3552875

3552876

3552877

3552878

3552880

3552881

3552882

3552884

3552885

3552886

3552888

3552889

3552890

3552892

3552893

3552894

3552896

3552897

3552899

3552900

3552901

3552903

3552904

3552906

3552907

3552908

3552909

3552910

3552912

3552913

3552914

3552915

3552919

3552922

3552923

3552924

3552925

3552926

3552928

3552929

3552930

3552932

3552933

3552934

3552936

3552937

3552938

3552941

3552945

3552946

3552947

3552948

3552950

3552951

3552952

3552953

3552954

3552955

3552956

3552957

3552958

3552959

3552962

3552964

3552966

3552969

3552970

3552971

3552974

3552975

3552976

3552977

3552978

3552979

3552980

3552981

3552982

3552996

3552997

3552999

37300_at

50084_at

7976876

A_14_P118619

GE53058

GO:0000166

GO:0000278

GO:0003723

GO:0003774

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005881

GO:0005938

GO:0007010

GO:0007018

GO:0007049

GO:0007052

GO:0007059

GO:0007097

GO:0008090

GO:0008569

GO:0016020

GO:0016787

GO:0016887

GO:0030175

GO:0030286

GO:0031122

GO:0031410

GO:0032388

GO:0033962

GO:0034063

GO:0035578

GO:0043226

GO:0045505

GO:0051293

GO:0051301

GO:0051959

GO:0060236

GO:0070062

GO:0090235

GO:0120162

GO:0140657

GO:1904115

GO:1905832

HMNXSV003036130

Hs.302653.0.S1_3p_at

Hs.309947.0.A1_3p_s_at

Hs.7720.0.A1_3p_at

Hs.7720.3.A1_3p_at

PH_hs_0000792

TC14000777.hg

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

DYNC1H1 [extracellular region]

DYNC1H1 [cytosol]

Inferred To

DYNC1H1 [azurophil granule lumen] (Bos taurus)

DYNC1H1 [azurophil granule lumen] (Caenorhabditis elegans)

DYNC1H1 [azurophil granule lumen] (Canis familiaris)

DYNC1H1 [azurophil granule lumen] (Dictyostelium discoideum)

DYNC1H1 [azurophil granule lumen] (Drosophila melanogaster)

DYNC1H1 [azurophil granule lumen] (Gallus gallus)

DYNC1H1 [azurophil granule lumen] (Mus musculus)

DYNC1H1 [azurophil granule lumen] (Plasmodium falciparum)

DYNC1H1 [azurophil granule lumen] (Rattus norvegicus)

DYNC1H1 [azurophil granule lumen] (Saccharomyces cerevisiae)

DYNC1H1 [azurophil granule lumen] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001367.2

OpenTargets

ENSG00000197102

GeneCards

Q14204

HPA

ENSG00000197102-DYNC1H1

Ensembl

ENSG00000197102, ENST00000360184, ENSP00000348965

PRO

Q14204

Pharos - Targets

Q14204

Orphanet

20586

PDB

8PQV, 7Z8L, 8PR1, 8FDT, 6F3A, 6F1V, 7Z8H, 8PTK, 6F1Y, 8PQZ, 7Z8K, 6F38, 6F1T, 8PR0, 7Z8G, 6F1U, 7Z8J, 8PQY, 8DYU, 5NUG, 8FD6, 8DYV, 7Z8F, 8PR3, 5OWO, 8FCY, 7Z8I, 8PQW, 8FDU, 8PR2

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.766	8
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.725	4
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	20
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2

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