Reactome | YTHDC1 [nucleoplasm]

YTHDC1 [nucleoplasm]

Stable Identifier

R-HSA-9935812

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="19"YTH domain-containing protein 1, YTDC1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96MU7 YTHDC1

Gene Names

YTHDC1, KIAA1966, YT521

Chain

chain:1-727

Reference Genes

BioGPS Gene:91746 YTHDC1

COSMIC (genes):YTHDC1 YTHDC1

CTD Gene:91746 YTHDC1

dbSNP Gene:91746 YTHDC1

ENSEMBL:ENSG00000083896 YTHDC1

HGNC:30626 YTHDC1

KEGG:hsa:91746 YTHDC1

Monarch:91746 YTHDC1

NCBI Gene:91746 YTHDC1

UCSC:Q96MU7 YTHDC1

Reference Transcript

Other Identifiers

11717001_s_at

11717002_a_at

11740514_a_at

16982426

212455_PM_at

212455_at

228556_PM_at

228556_at

240459_PM_at

240459_at

2772016

2772018

2772019

2772020

2772021

2772022

2772023

2772024

2772025

2772027

2772028

2772031

2772033

2772034

2772035

2772038

2772042

2772043

2772044

2772045

2772046

2772047

2772050

2772051

2772053

2772054

2772055

2772059

2772060

2772061

2772062

2772065

2772066

39897_at

46050_r_at

75055_i_at

75057_r_at

8100714

83578_at

87919_at

91604_at

91746

A_23_P92590

A_24_P208961

A_32_P352697

GE56160

GO:0000381

GO:0000398

GO:0001701

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005886

GO:0006325

GO:0006376

GO:0006397

GO:0006406

GO:0006913

GO:0007283

GO:0008380

GO:0009048

GO:0010608

GO:0016071

GO:0016607

GO:0022414

GO:0043226

GO:0043488

GO:0048024

GO:0048160

GO:0048856

GO:0060090

GO:0065003

GO:0110104

GO:1990247

HMNXSV003033615

Hs.12797.3.S1_3p_at

Hs.159286.0.A1_3p_at

Hs.159286.0.A1_3p_x_at

Hs.331938.0.S1_3p_at

ILMN_1666111

ILMN_1670878

ILMN_1707506

PH_hs_0022198

TC04001259.hg

TC4_ctg9_hap1000003.hg

Participates

as an output of

RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)

as a component of

PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)

as an input of

The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 (Homo sapiens)

Inferred To

Ghost homologue of YTHDC1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of YTHDC1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of YTHDC1 [nucleoplasm] (Schizosaccharomyces pombe)

ythdc1 [nucleoplasm] (Xenopus tropicalis)

YTHDC1 [nucleoplasm] (Bos taurus)

YTHDC1 [nucleoplasm] (Canis familiaris)

YTHDC1 [nucleoplasm] (Drosophila melanogaster)

YTHDC1 [nucleoplasm] (Gallus gallus)

YTHDC1 [nucleoplasm] (Mus musculus)

YTHDC1 [nucleoplasm] (Rattus norvegicus)

YTHDC1 [nucleoplasm] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

3288

OpenTargets

ENSG00000083896

ENSEMBL

ENSP00000347888, ENST00000355665, ENST00000344157, ENST00000615500, ENSP00000479213, ENSP00000339245, ENSP00000484604, ENSG00000083896, ENSG00000275272, ENST00000613637

HPA

ENSG00000083896-YTHDC1

GeneCards

YTHDC1

PRO

Q96MU7

Pharos - Targets

Q96MU7

GlyGen

Q96MU7

PDB

6ZCN, 6T11, 8Q3A, 6SZR, 6SZY, 6ZD9, 6T08, 6T04, 7P8B, 8Q4U, 6T10, 6T0A, 6T0D, 6RT7, 8Q37, 2YUD, 6YNO, 8Q38, 4R3I, 7PJB, 7P88, 6SZ3, 8Q33, 7PO6, 6YNN, 8Q35, 8K2E, 6SZX, 6T09, 8Q2Y, 8Q4N, 6SZN, 8Q4W, 8Q4P, 6T05, 7P8A, 6T0O, 8Q2V, 7PJ7, 8Q2W, 6T02, 7PJA, 6T0X, 8Q31, 8Q39, 6YKZ, 8Q2R, 6YKI, 6T01, 7P87, 6SZ1, 8Q2T, 6YNK, 6YNI, 7L4X, 8Q3G, 6SZL, 8Q4R, 6T12, 6T06, 8Q4T, 8Q4M, 4R3H, 6WE8, 6YL0, 6T03, 8Q2X, 6YL8, 6RT6, 6YNP, 6WEA, 6YOQ, 6YM8, 8Q2S, 6SZ2, 8Q32, 6YNL, 6YNJ, 6ZCM, 6YM2, 7L4Y, 6SZT, 7P8F, 6T0C, 8Q4Q, 7PJP, 6YKE, 6T07, 8Q4V, 6WE9, 6RT4, 6YL9, 7PJ8, 8Q2U, 6YNM, 7PJ9, 6YKJ, 6SYZ, 6T0Z, 6RT5, 8Q2Q, 7PJQ

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49760 CLK2			0.782	7
UniProt:Q9H190 SDCB2			0.781	7
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.744	5
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.718	6
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.718	6
UniProt:Q15415 RBY1F			0.718	6
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.718	6
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.666	4
UniProt:P62995 TRA2B	2	TRA2B [cytosol] (R-HSA-9715137) TRA2B [nucleoplasm] (R-HSA-8850859)	0.666	4
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.567	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P0DJD3-2 RBMY1A1			0.556	3
UniProt:O15084 ANKRD28	2	ANKRD28 [cytosol] (R-HSA-5685714) ANKRD28 [nucleoplasm] (R-HSA-9686571)	0.556	3
UniProt:P60371 KRTAP10-6	1	KRTAP10-6 [cytosol] (R-HSA-6810247)	0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.556	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q13595 TRA2A			0.547	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q4G0J3 LARP7			0.483	2

Cite Us!