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RPS3 [nucleoplasm]
Stable Identifier
R-HSA-6798714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
40S small ribosomal protein 3, P23396, 40S ribosomal protein S3
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
18SE pre-40S particle [nucleoplasm] (Homo sapiens)
RPS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23396 RPS3
Gene Names
RPS3, OK/SW-cl.26
Chain
initiator methionine:, chain:2-243
Reference Genes
BioGPS Gene:6188 RPS3
COSMIC (genes):RPS3 RPS3
CTD Gene:6188 RPS3
dbSNP Gene:6188 RPS3
ENSEMBL:ENSG00000149273 RPS3
HGNC:10420 RPS3
KEGG:hsa:6188 RPS3
Monarch:6188 RPS3
NCBI Gene:6188 RPS3
OMIM:600454 RPS3
UCSC:P23396 RPS3
Reference Transcript
RefSeq:NM_001260507.1 RPS3
RefSeq:NM_001005.4 RPS3
RefSeq:NM_001260506.1 RPS3
RefSeq:NM_001256802.1 RPS3
Other Identifiers
11757129_at
11757130_x_at
11757131_at
11757264_s_at
16729103
16729126
17118802
208692_PM_at
208692_at
214208_at
2940643
2940649
3340547
3340548
3340549
3340550
3340551
3340552
3340553
3340554
3340555
3340556
3340557
3340558
3340559
3340560
3340561
3340562
3340563
3340564
3340565
3340566
3340567
3340568
3340569
3340570
3340571
3340572
3340577
34645_at
6188
63493_at
7942586
7942592
7942594
A_14_P112056
A_21_P0000223
A_23_P139376
A_24_P218765
A_33_P3578325
GE79155
GE84158
GO:0000977
GO:0002181
GO:0003677
GO:0003684
GO:0003723
GO:0003729
GO:0003735
GO:0003824
GO:0003906
GO:0004520
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005783
GO:0005819
GO:0005829
GO:0005840
GO:0005856
GO:0005886
GO:0005925
GO:0006281
GO:0006284
GO:0006355
GO:0006412
GO:0006413
GO:0006417
GO:0006915
GO:0006974
GO:0007010
GO:0007059
GO:0008017
GO:0008092
GO:0010628
GO:0012501
GO:0014069
GO:0015631
GO:0015935
GO:0016020
GO:0016787
GO:0016829
GO:0017148
GO:0019899
GO:0019900
GO:0019901
GO:0022626
GO:0022627
GO:0030544
GO:0031116
GO:0031334
GO:0031397
GO:0032079
GO:0032357
GO:0032358
GO:0032587
GO:0032743
GO:0034614
GO:0042104
GO:0042981
GO:0043226
GO:0043507
GO:0044390
GO:0044877
GO:0045202
GO:0045738
GO:0045739
GO:0050862
GO:0051018
GO:0051092
GO:0051225
GO:0051301
GO:0051536
GO:0051879
GO:0061481
GO:0070062
GO:0070181
GO:0070301
GO:0071159
GO:0071356
GO:0072686
GO:0097100
GO:0140078
GO:0140097
GO:0140297
GO:1901224
GO:1902231
GO:1905053
GO:1990904
GO:2001235
GO:2001272
HMNXSV003006450
HMNXSV003035177
HMNXSV003045985
Hs.59728.0.A1_3p_at
ILMN_1713832
ILMN_1760714
ILMN_1767869
PH_hs_0030001
PH_hs_0036216
PH_hs_0036296
RNA33435|snoRNA_scaRNA_31_146
TC11000806.hg
TC11000807.hg
TC11000808.hg
X55715_at
g555940_3p_at
Participates
as a component of
18SE pre-40S particle [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RPS3 [cytosol]
Inferred To
Homologues of RPS3 [nucleoplasm]
(Sus scrofa)
RpS3 [nucleoplasm]
(Drosophila melanogaster)
RPS3 [nucleoplasm]
(Bos taurus)
RPS3 [nucleoplasm]
(Canis familiaris)
RPS3 [nucleoplasm]
(Gallus gallus)
RPS3 [nucleoplasm]
(Plasmodium falciparum)
RPS3 [nucleoplasm]
(Saccharomyces cerevisiae)
RPS3 [nucleoplasm]
(Sus scrofa)
rps3 [nucleoplasm]
(Danio rerio)
rps3 [nucleoplasm]
(Dictyostelium discoideum)
rps3 [nucleoplasm]
(Schizosaccharomyces pombe)
rps3 [nucleoplasm]
(Xenopus tropicalis)
Rps3 [nucleoplasm]
(Mus musculus)
Rps3 [nucleoplasm]
(Rattus norvegicus)
rps-3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001243731.1
,
NP_001247435.1
,
NP_001247436.1
,
NP_000996.2
OpenTargets
ENSG00000149273
ENSEMBL
ENST00000524851
,
ENST00000527446
,
ENST00000278572
,
ENST00000531188
,
ENSP00000436971
,
ENSP00000278572
,
ENSP00000434643
,
ENSP00000433821
IntEnz
4.2.99.18
HPA
ENSG00000149273-RPS3
PRO
P23396
Pharos - Targets
P23396
GlyGen
P23396
PDB
7XNX
,
7QVP
,
6OLG
,
6Z6M
,
6Z6L
,
8PPL
,
6ZN5
,
1WH9
,
8G60
,
6OLI
,
8G5Y
,
4V6X
,
8JDL
,
6OLF
,
5VYC
,
6OLE
,
8JDM
,
8JDK
,
6G53
,
6ZXH
,
6OM7
,
7R4X
,
7K5I
,
6QZP
,
6ZME
,
5T2C
,
6Y57
,
5OA3
,
8GLP
,
5AJ0
,
6IP5
,
7A09
,
6FEC
,
8OZ0
,
6YBS
,
6ZON
,
5FLX
,
7QP7
,
6ZVH
,
7XNY
,
6ZMI
,
6Y0G
,
8T4S
,
8G5Z
,
6ZMT
,
8XXN
,
8Y0W
,
8Y0X
,
8XXL
,
6Z6N
,
6ZV6
,
6ZVJ
,
8IFE
,
6OLZ
,
8PPK
,
6G51
,
8JDJ
,
6OM0
,
5A2Q
,
8G61
,
8QOI
,
6ZXF
,
8G6J
,
5LKS
,
4UG0
,
6Y2L
,
6ZXE
,
6ZP4
,
6G5I
,
6ZXD
,
6ZUO
,
6G5H
,
7TQL
,
6ZXG
,
6ZM7
,
6XA1
,
6IP6
,
6ZLW
,
6ZOL
,
6IP8
,
7QP6
,
6ZMO
,
8XXM
,
6ZOJ
,
8IFD
,
6ZMW
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.797
8
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.787
5
UniProt:Q96GA3 LTV1
2
LTV1 [cytosol]
(R-HSA-6791520)
LTV1 [nucleoplasm]
(R-HSA-6791566)
0.737
5
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.706
4
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.686
8
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.677
6
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.643
6
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.642
4
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.623
5
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
NEDD8 [cytosol]
(R-HSA-416969)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
0.623
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.602
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.59
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.527
3
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
3
UniProt:P62249 RPS16
2
RPS16 [cytosol]
(R-HSA-72337)
RPS16 [nucleoplasm]
(R-HSA-6791196)
0.527
3
UniProt:Q01523 DEFA5
5
DEFA5(1-94) [Golgi lumen]
(R-HSA-1467267)
DEFA5(20-94) [Golgi lumen]
(R-HSA-1467208)
DEFA5(20-94) [secretory granule lumen]
(R-HSA-1471358)
DEFA5(20-94) [extracellular region]
(R-HSA-1471344)
DEFA5(?-94) [extracellular region]
(R-HSA-1462017)
0.527
2
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
2
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.527
2
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.483
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:Q5VYS8 ZCCHC6
1
TUT7 [cytosol]
(R-HSA-8941313)
0.483
2
UniProt:Q00341 HDLBP
1
HDLBP [plasma membrane]
(R-HSA-8858026)
0.483
2
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