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p-Y179-NGEF [cytosol]
Stable Identifier
R-HSA-3928441
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ephexin-1, NGEF_HUMAN, NGEF
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
p-Y179-NGEF [cytosol] (Homo sapiens)
p-Y179-NGEF [cytosol] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
p-Y179-NGEF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N5V2 NGEF
Gene Names
NGEF
Chain
chain:1-710
Reference Genes
BioGPS Gene:25791 NGEF
COSMIC (genes):NGEF NGEF
CTD Gene:25791 NGEF
dbSNP Gene:25791 NGEF
ENSEMBL:ENSG00000066248 NGEF
HGNC:7807 NGEF
KEGG Gene (Homo sapiens):25791 NGEF
Monarch:25791 NGEF
NCBI Gene:25791 NGEF
OMIM:605991 NGEF
UCSC:Q8N5V2 NGEF
Reference Transcript
RefSeq:NM_019850.2 NGEF
RefSeq:XM_011510923.2 NGEF
RefSeq:NM_001114090.1 NGEF
Other Identifiers
0007000735
11720569_a_at
11741243_a_at
11752385_a_at
16909608
227240_at
243556_at
25791
2603988
2603989
2603990
2603992
2603993
2603994
2603997
2603998
2604000
2604001
2604003
2604004
2604011
2604012
2604013
2604014
2604020
2604024
2604025
2604031
2604033
2604034
2604037
45561_at
52384_s_at
62570_at
76705_at
8059783
A_23_P102364
A_33_P3240094
GE86970
GO:0000902
GO:0003674
GO:0005085
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0007165
GO:0007186
GO:0007275
GO:0007399
GO:0008150
GO:0008219
GO:0016020
GO:0019899
GO:0030154
GO:0030426
GO:0034330
GO:0042995
GO:0043065
GO:0043087
GO:0048013
GO:0048856
GO:0051056
GO:0061002
GO:0090630
HMNXSV003026937
HMNXSV003031655
Hs.237517.0.A1_3p_at
Hs.271507.0.S1_3p_at
ILMN_1809613
PH_hs_0012859
TC02002880.hg
Participates
as a component of
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
Other forms of this molecule
NGEF [cytosol]
Inferred To
phospho-ngef [cytosol]
(Danio rerio)
phospho-NGEF [cytosol]
(Bos taurus)
phospho-NGEF [cytosol]
(Canis familiaris)
phospho-NGEF [cytosol]
(Gallus gallus)
phospho-NGEF [cytosol]
(Sus scrofa)
phospho-Ngef [cytosol]
(Mus musculus)
phospho-Ngef [cytosol]
(Rattus norvegicus)
phospho-ephx-1 [cytosol]
(Caenorhabditis elegans)
phospho-Exn [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at 179
Coordinate
179
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011509225.1
,
NP_062824.2
,
NP_001107562.1
OpenTargets
ENSG00000066248
GeneCards
Q8N5V2
HPA
ENSG00000066248-NGEF
Ensembl
ENSP00000387033
,
ENSP00000362653
,
ENSG00000066248
,
ENST00000373552
,
ENST00000264051
,
ENST00000409079
,
ENSP00000264051
PRO
Q8N5V2
HMDB Protein
HMDBP11508
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:P28799 GRN
2
GRN [extracellular region]
(R-HSA-6806217)
GRN [azurophil granule lumen]
(R-HSA-6799168)
0.556
3
UniProt:P01112 HRAS
23
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.556
3
UniProt:P22607 FGFR3
40
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 795fs*139 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
p-6Y-FGFR3 S371C [plasma membrane]
(R-HSA-2011886)
p-6Y-FGFR3 G370C [plasma membrane]
(R-HSA-2011883)
p-6Y-FGFR3 Y373C [plasma membrane]
(R-HSA-2011889)
p-6Y-FGFR3 795fs*139 [plasma membrane]
(R-HSA-2038360)
p-6Y-FGFR3 R248C [plasma membrane]
(R-HSA-2011884)
pY-FGFR3 [plasma membrane]
(R-HSA-2038368)
p-6Y-FGFR3 K650Q [plasma membrane]
(R-HSA-2032962)
p-6Y-FGFR3 K650N [plasma membrane]
(R-HSA-2032961)
p-6Y-FGFR3 K650E [plasma membrane]
(R-HSA-2032952)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853147)
p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853155)
p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853145)
p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853129)
p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853151)
p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853128)
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P06396 GSN
7
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P08631-2 HCK
0.488
2
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