Reactome | p-Y179-NGEF [cytosol]

p-Y179-NGEF [cytosol]

Stable Identifier

R-HSA-3928441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ephexin-1, NGEF_HUMAN, NGEF

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External Reference Information

External Reference

UniProt:Q8N5V2 NGEF

Gene Names

NGEF

Chain

chain:1-710

Reference Genes

BioGPS Gene:25791 NGEF

COSMIC (genes):NGEF NGEF

CTD Gene:25791 NGEF

dbSNP Gene:25791 NGEF

ENSEMBL:ENSG00000066248 NGEF

ENSEMBL_homo_sapiens_GENE:ENSG00000066248.15 NGEF

HGNC:7807 NGEF

KEGG Gene (Homo sapiens):25791 NGEF

Monarch:25791 NGEF

NCBI Gene:25791 NGEF

OMIM:605991 NGEF

UCSC:Q8N5V2 NGEF

Reference Transcript

Other Identifiers

11720569_a_at

11741243_a_at

11752385_a_at

16909608

227240_PM_at

227240_at

243556_PM_at

243556_at

25791

2603988

2603989

2603990

2603992

2603993

2603994

2603997

2603998

2604000

2604001

2604003

2604004

2604011

2604012

2604013

2604014

2604020

2604024

2604025

2604031

2604033

2604034

2604037

45561_at

52384_s_at

62570_at

76705_at

8059783

A_23_P102364

A_33_P3240094

GE86970

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0007399

GO:0016020

GO:0023052

GO:0030154

GO:0030426

GO:0034330

GO:0042995

GO:0043087

GO:0048013

GO:0048856

GO:0051056

GO:0061002

GO:0098772

HMNXSV003026937

HMNXSV003031655

Hs.237517.0.A1_3p_at

Hs.271507.0.S1_3p_at

ILMN_1809613

PH_hs_0012859

RNA147288|p0392_imsncRNA810

TC02002880.hg

Participates

as a component of

EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)

Other forms of this molecule

NGEF [cytosol]

Inferred To

phospho-ngef [cytosol] (Xenopus tropicalis)

Ghost homologue of p-Y179-NGEF [cytosol] (Danio rerio)

phospho-NGEF [cytosol] (Bos taurus)

phospho-NGEF [cytosol] (Canis familiaris)

phospho-NGEF [cytosol] (Sus scrofa)

phospho-p-Y179-NGEF [cytosol] (Gallus gallus)

phospho-Ngef [cytosol] (Mus musculus)

phospho-Ngef [cytosol] (Rattus norvegicus)

phospho-ephx-1 [cytosol] (Caenorhabditis elegans)

phospho-Exn [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at 179

Coordinate

179

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011509225.1, NP_001107562.1, NP_062824.2

OpenTargets

ENSG00000066248

GeneCards

Q8N5V2

HPA

ENSG00000066248-NGEF

Ensembl

ENSP00000387033, ENST00000373552, ENSG00000066248, ENST00000409079, ENST00000264051, ENSP00000362653, ENSP00000264051

PRO

Q8N5V2

Pharos - Targets

Q8N5V2

HMDB Protein

HMDBP11508

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [secretory granule lumen] (R-HSA-6801082) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063)	0.527	2
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.527	2
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.527	2
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	3
UniProt:P08631-2 HCK			0.488	2

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