Reactome | Ub,SUMO-XPC [nucleoplasm]

Ub,SUMO-XPC [nucleoplasm]

Stable Identifier

R-HSA-6790460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO-XPC [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO-XPC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01831 XPC

Gene Names

XPC, XPCC

Chain

initiator methionine:1, chain:2-940

Reference Genes

BioGPS Gene:7508 XPC

COSMIC (genes):XPC XPC

CTD Gene:7508 XPC

dbSNP Gene:7508 XPC

ENSEMBL:ENSG00000154767 XPC

ENSEMBL:ENSG00000154767.15 XPC

HGNC:12816 XPC

KEGG Gene (Homo sapiens):7508 XPC

Monarch:7508 XPC

NCBI Gene:7508 XPC

OMIM:613208 XPC

UCSC:Q01831 XPC

Reference Transcript

RefSeq:NM_004628.4 XPC

Other Identifiers

11728207_a_at

11740553_a_at

16951007

1873_at

209375_PM_at

209375_at

2663807

2663809

2663811

2663812

2663813

2663814

2663815

2663817

2663820

2663823

2663824

2663828

2663834

2663835

2663836

2663837

2663839

2663840

2663841

2663842

2663843

2663844

2663847

2663848

2663849

2663850

2663851

2663852

2663853

2663855

2663856

35647_at

7508

8085486

D21089_at

GE57108

GO:0000109

GO:0000111

GO:0000278

GO:0000404

GO:0000405

GO:0000720

GO:0000785

GO:0003677

GO:0003684

GO:0003697

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006281

GO:0006289

GO:0006298

GO:0006351

GO:0006355

GO:0006974

GO:0009410

GO:0010224

GO:0010996

GO:0023052

GO:0031573

GO:0043226

GO:0043231

GO:0044877

GO:0045893

GO:0061629

GO:0070914

GO:0071942

GO:0090734

GO:0140110

GO:0140299

GO:0140612

GO:1901990

HMNXSV003012819

HMNXSV003019064

ILMN_1790807

PH_hs_0000038

PH_hs_0030850

TC03001194.hg

TC03002817.hg

g475156_3p_at

Participates

as a component of

Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K655-XPC [nucleoplasm]

Ub,SUMO,K63polyUb-XPC [nucleoplasm]

Ub-XPC [nucleoplasm]

XPC [nucleoplasm]

Inferred To

XPC [nucleoplasm] (Bos taurus)

XPC [nucleoplasm] (Sus scrofa)

Ub,SUMO-XPC [nucleoplasm] (Canis familiaris)

Ub,SUMO-XPC [nucleoplasm] (Gallus gallus)

rad4 [nucleoplasm] (Dictyostelium discoideum)

xpc-1 [nucleoplasm] (Caenorhabditis elegans)

Xpc [nucleoplasm] (Drosophila melanogaster)

Xpc [nucleoplasm] (Mus musculus)

Xpc [nucleoplasm] (Rattus norvegicus)

wu:fb12d05 [nucleoplasm] (Danio rerio)

xpc [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

sumoylated lysine at unknown position

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_004619.3

OpenTargets

ENSG00000154767

HPA

ENSG00000154767-XPC

GeneCards

Q01831

Ensembl

ENSP00000424548, ENST00000285021, ENSG00000154767, ENST00000476581, ENSP00000285021

PRO

Q01831

Pharos - Targets

Q01831

Orphanet

15736

HMDB Protein

HMDBP12797

PDB

2RVB, 2GGM, 2A4J, 2OBH

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.779	9
UniProt:P41208 CETN2	3	polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486) CETN2 [nucleoplasm] (R-HSA-4570490) CETN2 [cytosol] (R-HSA-380298)	0.777	7
UniProt:P13288 KR2			0.645	9
UniProt:Q9R1K9	3	polySUMO2,3-CETN2 [nucleoplasm] (R-MMU-4570486) CETN2 [nucleoplasm] (R-MMU-4570490) CETN2 [cytosol] (R-MMU-380298)	0.564	2
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.527	2
UniProt:O15182 CETN3			0.527	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.527	2
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.483	2

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