Reactome | STAG2 [nucleoplasm]

STAG2 [nucleoplasm]

Stable Identifier

R-HSA-163046

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SA2, Cohesin subunit SA-2, SCC3 homolog 2

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
        
        Cohesin Complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - BRCA1 is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Synapsis (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N3U4 STAG2

Gene Names

STAG2, SA2

Chain

chain:1-1231

Reference Genes

COSMIC (genes):STAG2 STAG2

dbSNP Gene:10735 STAG2

ENSEMBL:ENSG00000101972 STAG2

Participates

as a component of

Other forms of this molecule

monoSUMO1-K-STAG2 [nucleoplasm]

STAG2 [cytosol]

p-STAG2 [chromosome]

p-STAG2 [cytosol]

p-STAG2 [chromosome, centromeric region]

STAG2 [chromosome]

STAG2 [chromosome, centromeric region]

Inferred To

psc3 [nucleoplasm] (Schizosaccharomyces pombe)

Cohesin subunit SA-2 [nucleoplasm] (Mus musculus)

stag2b [nucleoplasm] (Danio rerio)

Homologues of STAG2 [nucleoplasm] (Drosophila melanogaster)

Homologues of STAG2 [nucleoplasm] (Schizosaccharomyces pombe)

SA1 [nucleoplasm] (Drosophila melanogaster)

Stag2 [nucleoplasm] (Rattus norvegicus)

scc-3 [nucleoplasm] (Caenorhabditis elegans)

IRR1 [nucleoplasm] (Saccharomyces cerevisiae)

SA2 [nucleoplasm] (Drosophila melanogaster)

STAG2 [nucleoplasm] (Bos taurus)

STAG2 [nucleoplasm] (Canis familiaris)

STAG2 [nucleoplasm] (Dictyostelium discoideum)

STAG2 [nucleoplasm] (Gallus gallus)

STAG2 [nucleoplasm] (Sus scrofa)

rec11 [nucleoplasm] (Schizosaccharomyces pombe)

stag2 [nucleoplasm] (Xenopus tropicalis)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.967	23
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.922	14
UniProt:Q5FBB7 SGO1	3	SGOL1 [cytosol] (R-HSA-376227) SGO1 [nucleoplasm] (R-HSA-2468161) p-S-SGO1 [nucleoplasm] (R-HSA-9929718)	0.774	7
UniProt:Q9CPY3	6	phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.643	5
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.577	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.539	3

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