Reactome | UBQLN2 [cytosol]

UBQLN2 [cytosol]

Stable Identifier

R-HSA-8866007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquilin-2, UBQL2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UHD9 UBQLN2

Gene Names

UBQLN2, N4BP4, PLIC2, HRIHFB2157

Chain

initiator methionine:1, chain:2-624

Reference Genes

BioGPS Gene:29978 UBQLN2

COSMIC (genes):UBQLN2 UBQLN2

CTD Gene:29978 UBQLN2

dbSNP Gene:29978 UBQLN2

ENSEMBL:ENSG00000188021.9 UBQLN2

HGNC:12509 UBQLN2

KEGG Gene (Homo sapiens):29978 UBQLN2

Monarch:29978 UBQLN2

NCBI Gene:29978 UBQLN2

OMIM:300264 UBQLN2

UCSC:Q9UHD9 UBQLN2

Reference Transcript

RefSeq:NM_013444.3 UBQLN2

Other Identifiers

11716768_a_at

11746046_a_at

11758656_s_at

17104176

215884_PM_s_at

215884_s_at

239888_PM_at

239888_at

29978

34824_at

3978682

3979001

3979002

3979003

3979004

3979005

3979006

3979007

3979008

3979009

3979010

3979011

3979012

3979013

44866_s_at

51353_at

8167924

A_14_P124954

A_14_P202225

A_23_P114164

GE54953

GO:0000045

GO:0005515

GO:0005634

GO:0005737

GO:0005773

GO:0005776

GO:0005829

GO:0005886

GO:0006511

GO:0006914

GO:0016020

GO:0016192

GO:0016241

GO:0023052

GO:0030163

GO:0030433

GO:0031410

GO:0031593

GO:0032434

GO:0033554

GO:0042802

GO:0043226

GO:0060090

GO:0140693

GO:1900186

GO:1903071

GO:1904021

GO:2000785

HMNXSV003025863

Hs.179309.0.A1_3p_at

Hs.4552.1.S1_3p_a_at

ILMN_1680770

PH_hs_0027549

TC0X000339.hg

Participates

as a member of

UBQLN2,1 [cytosol] (Homo sapiens)

as a component of

UBQLN2:UIM-containing proteins [cytosol] (Homo sapiens)

Inferred To

Dmel\CG31528 [cytosol] (Drosophila melanogaster)

Ubqln2 [cytosol] (Mus musculus)

Ubqln2 [cytosol] (Rattus norvegicus)

Ubqn [cytosol] (Drosophila melanogaster)

Homologues of UBQLN2 [cytosol] (Caenorhabditis elegans)

Homologues of UBQLN2 [cytosol] (Drosophila melanogaster)

Homologues of UBQLN2 [cytosol] (Gallus gallus)

Homologues of UBQLN2 [cytosol] (Plasmodium falciparum)

Homologues of UBQLN2 [cytosol] (Schizosaccharomyces pombe)

ubql-1 [cytosol] (Caenorhabditis elegans)

DSK2 [cytosol] (Saccharomyces cerevisiae)

ubqln [cytosol] (Dictyostelium discoideum)

ubqln1 [cytosol] (Xenopus tropicalis)

dph1 [cytosol] (Schizosaccharomyces pombe)

UBQLN2 [cytosol] (Bos taurus)

UBQLN2 [cytosol] (Caenorhabditis elegans)

UBQLN2 [cytosol] (Gallus gallus)

UBQLN2 [cytosol] (Plasmodium falciparum)

UBQLN2 [cytosol] (Schizosaccharomyces pombe)

UBQLN2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_038472.2

OpenTargets

ENSG00000188021

HPA

ENSG00000188021-UBQLN2

GeneCards

Q9UHD9

Ensembl

ENSP00000345195, ENST00000338222, ENSG00000188021

PRO

Q9UHD9

Pharos - Targets

Q9UHD9

Orphanet

20541

PDB

7F7X, 2NBV, 6MUN, 1J8C

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.713	5
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.601	4
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.556	3
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.556	6
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:P00742 F10	13	11xCbxE-3D-F10(41-179) [Golgi lumen] (R-HSA-159718) factor X light chain propeptide [Golgi lumen] (R-HSA-159824) 11xCbxE-3D-F10(32-179) [Golgi lumen] (R-HSA-159774) factor X heavy chain [Golgi lumen] (R-HSA-159846) 11xCbxE-3D-F10(32-179) [endoplasmic reticulum lumen] (R-HSA-159786) factor X heavy chain [endoplasmic reticulum lumen] (R-HSA-159776) 3D-F10(32-179) [endoplasmic reticulum lumen] (R-HSA-159810) factor X activation peptide [extracellular region] (R-HSA-140785) factor X heavy chain [extracellular region] (R-HSA-140738) 11xCbxE-3D-F10(41-179) [extracellular region] (R-HSA-140687) factor Xa heavy chain [extracellular region] (R-HSA-140688) 11xCbxE-3D-F10(41-179) [plasma membrane] (R-HSA-140631) factor Xa heavy chain [plasma membrane] (R-HSA-140642)	0.556	3
UniProt:Q07654 TFF3	1	TFF3 [extracellular region] (R-HSA-9017888)	0.556	3
UniProt:P05121 SERPINE1	3	SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [extracellular region] (R-HSA-158797)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:Q9UNW1 MINPP1	1	MINPP1 [endoplasmic reticulum lumen] (R-HSA-1604613)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.556	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [extracellular region] (R-HSA-1454879) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q15726 KISS1	1	KISS1(68-121) [extracellular region] (R-HSA-389043)	0.556	3
UniProt:Q8TCZ2 CD99L2	1	CD99L2 [plasma membrane] (R-HSA-8867207)	0.556	3
UniProt:Q9UHM6 OPN4	1	OPN4 [photoreceptor disc membrane] (R-HSA-391825)	0.556	3
UniProt:P01160 NPPA	5	NPPA(26-55) [extracellular region] (R-HSA-5578794) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-153) [extracellular region] (R-HSA-976950)	0.556	3
UniProt:O15467 CCL16	1	CCL16 [extracellular region] (R-HSA-373103)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:Q969H8 MYDGF	1	C19orf10 [endoplasmic reticulum lumen] (R-HSA-535584)	0.556	3
UniProt:P01303 NPY	1	NPY [extracellular region] (R-HSA-388906)	0.556	3
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) Ub-48-UBA52(1-76) [lysosomal membrane] (R-HSA-9762994) Ub-48-UBA52(1-76) [endocytic vesicle membrane] (R-HSA-9763054) UBA52(1-76) [endosome membrane] (R-HSA-939189) UBA52(1-76) [plasma membrane] (R-HSA-3149452) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082) Ub-33-UBA52(1-76) [cytosol] (R-HSA-5689141)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.556	3
UniProt:P20809 IL11	1	IL11 [extracellular region] (R-HSA-447097)	0.556	3
UniProt:P05814 CSN2	1	CSN2 [extracellular region] (R-HSA-1254293)	0.556	6
UniProt:P59665 DEFA1	9	DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282)	0.556	3
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.556	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.556	3
UniProt:P08294 SOD3	3	SOD3 [Golgi lumen] (R-HSA-3697878) SOD3 (19-227) [extracellular region] (R-HSA-4837350) SOD3 [extracellular region] (R-HSA-3299690)	0.556	3
UniProt:P08123 COL1A2	20	GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023602) 3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023558) GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023547) 3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023674) 3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023580) 3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023663) 3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022070) 3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022501) 3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022977) 3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022966) 5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022455) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396490) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396080) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396375) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396493) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396241) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396064) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396361) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396431) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396174)	0.556	5
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.556	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.556	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.556	3
UniProt:P16150 SPN	1	SPN [plasma membrane] (R-HSA-204438)	0.556	3
UniProt:Q9UMD9 COL17A1	20	GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172232) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) 3x4Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173162) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173230) 5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173044) 3x4Hyp-GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471866) 5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471851) 3x4Hyp-3Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471867) 3x4Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471913) 3x4Hyp-3Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471897) COL17A1(?-1497) [extracellular region] (R-HSA-2471870) GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471903) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471916)	0.556	3
UniProt:Q8NBS9 TXNDC5	4	TXNDC5 [Golgi lumen] (R-HSA-434325) TXNDC5 [lysosomal lumen] (R-HSA-429813) TXNDC5 [extracellular region] (R-HSA-6806246) TXNDC5 [azurophil granule lumen] (R-HSA-6799367)	0.556	3
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	5
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.524	2

Cite Us!