Reactome | SORL1 [endosome membrane]

SORL1 [endosome membrane]

Stable Identifier

R-HSA-8871475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Sortilin-related receptor, SORL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92673 SORL1

Gene Names

SORL1, C11orf32

Chain

signal peptide:1-28, propeptide:29-81, chain:82-2214

Reference Genes

COSMIC (genes):SORL1 SORL1

dbSNP Gene:6653 SORL1

ENSEMBL:ENSG00000137642 SORL1

Participates

as a component of

SORL1:APP(18-770) [endosome lumen] (Homo sapiens)

as an input of

SORL1 binds APP(18-770) (Homo sapiens)

Other forms of this molecule

SORL1 [Golgi membrane]

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673-PRO_0000033164 SORL1			0.813	9
UniProt:P30533 AMRP			0.8	5
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.774	6
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.744	5
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.727	8
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.69	5
UniProt:P26992 CNTFR	1	CNTFR [plasma membrane] (R-HSA-5696438)	0.672	7
UniProt:P08887 IL6R	1	IL6R [plasma membrane] (R-HSA-197824)	0.619	7
UniProt:P05067-PRO_0000000093 APP			0.618	3
UniProt:P39905-PRO_0000034005 GDNF			0.571	6
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.571	4
UniProt:Q62997 Gfra1	2	GFRalpha-1 [plasma membrane] (R-RNO-420354) Gfra1 [plasma membrane] (R-RNO-375067)	0.567	5
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q15669 RHOH	1	RHOH [plasma membrane] (R-HSA-194859)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	3
UniProt:Q8N0S8 Q8N0S8			0.556	3
UniProt:P00491 PNP	7	PNP [secretory granule lumen] (R-HSA-6803318) PNP [extracellular region] (R-HSA-6806505) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278) PNP [cytosol] (R-HSA-61933) PNP D128G [cytosol] (R-HSA-9735785) PNP E89K [cytosol] (R-HSA-9735781) PNP R234P [cytosol] (R-HSA-9735772)	0.556	3
IntAct:EBI-16882364 CALM1			0.556	3
IntAct:EBI-25857140 ORF			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.556	3
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P05067-8 APP			0.554	2
UniProt:O75462 CRLF1	2	CRLF1 [cytosol] (R-HSA-8950296) CRLF1 [extracellular region] (R-HSA-5693174)	0.544	3
UniProt:P56159-2 GFRA1			0.544	3
UniProt:O43301 HSPA12A	2	HSPA12A [cytosol] (R-HSA-5252017) HSPA12A [nucleoplasm] (R-HSA-5252130)	0.543	5
UniProt:O00214 LEG8			0.527	2
UniProt:Q6ZMY9 ZNF517	1	ZNF517 [nucleoplasm] (R-HSA-1973869)	0.527	2
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.527	2
UniProt:Q6IPR3 TYW3	1	TYW3 [cytoplasm] (R-HSA-6782888)	0.527	3
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667)	0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:P15408 FOSL2			0.527	3
UniProt:Q9NZL3 ZNF224	1	ZNF224 [nucleoplasm] (R-HSA-1027352)	0.527	2
UniProt:O95395 GCNT3	1	GCNT3 [Golgi membrane] (R-HSA-914013)	0.527	4
UniProt:O43296 ZNF264	1	ZNF264 [nucleoplasm] (R-HSA-1027386)	0.527	3
UniProt:Q8TA94 ZNF563	1	ZNF563 [nucleoplasm] (R-HSA-1973875)	0.527	2
UniProt:Q14929 ZNF169	1	ZNF169 [nucleoplasm] (R-HSA-975014)	0.527	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	3
UniProt:Q86Y25 ZNF354C	1	ZNF354C [nucleoplasm] (R-HSA-1247525)	0.527	2
UniProt:Q3SY56 SP6			0.527	3
UniProt:P05067-PRO_0000000091 APP			0.518	4
UniProt:O75462-PRO_0000011039 CRLF1			0.463	2