Reactome | PABPC1 [cytosol]

PABPC1 [cytosol]

Stable Identifier

R-HSA-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PABP

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External Reference Information

External Reference

UniProt:P11940 PABPC1

Gene Names

PABPC1, PAB1, PABP, PABP1, PABPC2

Chain

chain:1-636

Reference Genes

BioGPS Gene:26986 PABPC1

COSMIC (genes):PABPC1 PABPC1

CTD Gene:26986 PABPC1

dbSNP Gene:26986 PABPC1

ENSEMBL:ENSG00000070756 PABPC1

ENSEMBL:ENSG00000070756.17 PABPC1

HGNC:8554 PABPC1

KEGG Gene (Homo sapiens):26986 PABPC1

Monarch:26986 PABPC1

NCBI Gene:26986 PABPC1

OMIM:604679 PABPC1

UCSC:P11940 PABPC1

Reference Transcript

Other Identifiers

11748097_x_at

11752278_x_at

11754246_x_at

17079672

215157_3p_x_at

215157_PM_x_at

215157_x_at

26986

2701791

2766680

3146787

3146788

3146789

3146791

3146793

3146794

3146795

3146796

3146799

3146801

3146802

3146805

3146806

3146807

3146809

3146812

3146814

3146815

3146819

3146820

3146821

3146822

3146823

3146824

3146825

3146826

3146827

31950_at

31951_s_at

3419625

3419626

3482124

59809_f_at

64962_r_at

8152079

GE60230

GO:0000184

GO:0000398

GO:0002181

GO:0003676

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005681

GO:0005737

GO:0005829

GO:0005925

GO:0006378

GO:0006397

GO:0008143

GO:0008266

GO:0008380

GO:0008494

GO:0010494

GO:0016020

GO:0016071

GO:0030027

GO:0031047

GO:0031252

GO:0036464

GO:0042995

GO:0043226

GO:0045070

GO:0045182

GO:0048255

GO:0060213

GO:0070062

GO:0070934

GO:0071013

GO:0106002

GO:1900152

GO:1900153

GO:1990904

GO:2000623

GO:2000767

HMNXSV003038156

Hs.172182.2.A1_3p_s_at

ILMN_2136133

PH_hs_0028309

TC08001481.hg

U68105_s_at

Z48501_s_at

Participates

as a component of

as an input of

as an output of

Inferred To

Dmel\CG4612 [cytosol] (Drosophila melanogaster)

Homologues of PABPC1 [cytosol] (Caenorhabditis elegans)

Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)

Homologues of PABPC1 [cytosol] (Drosophila melanogaster)

Homologues of PABPC1 [cytosol] (Plasmodium falciparum)

Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)

pabpc1B [cytosol] (Dictyostelium discoideum)

rnp24 [cytosol] (Schizosaccharomyces pombe)

PAB1 [cytosol] (Saccharomyces cerevisiae)

pabpc1A [cytosol] (Dictyostelium discoideum)

pab-2 [cytosol] (Caenorhabditis elegans)

crp79 [cytosol] (Schizosaccharomyces pombe)

pAbp [cytosol] (Drosophila melanogaster)

pabpc1a [cytosol] (Danio rerio)

pab-1 [cytosol] (Caenorhabditis elegans)

pabpc1 [cytosol] (Xenopus tropicalis)

PES4 [cytosol] (Saccharomyces cerevisiae)

pab1 [cytosol] (Schizosaccharomyces pombe)

PABPC1 [cytosol] (Bos taurus)

PABPC1 [cytosol] (Canis familiaris)

PABPC1 [cytosol] (Dictyostelium discoideum)

PABPC1 [cytosol] (Gallus gallus)

PABPC1 [cytosol] (Plasmodium falciparum)

PABPC1 [cytosol] (Sus scrofa)

MIP6 [cytosol] (Saccharomyces cerevisiae)

Pabpc1 [cytosol] (Mus musculus)

Pabpc1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002559.2, XP_005250918.1

OpenTargets

ENSG00000070756

HPA

ENSG00000070756-PABPC1

GeneCards

P11940

Ensembl

ENSP00000313007, ENSP00000428749, ENST00000520804, ENSP00000428840, ENST00000522658, ENST00000521865, ENSP00000429119, ENSP00000429790, ENSP00000429892, ENST00000318607, ENSP00000430012, ENSG00000070756, ENST00000522720, ENST00000523555, ENST00000520142

PRO

P11940

Pharos - Targets

P11940

PDB

5LGS, 3KUS, 1JGN, 2X04, 3PTH, 4F25, 2RQH, 7BN3, 5DXA, 3KUR, 3KTR, 5LGR, 2RQG, 1G9L, 4F02, 3PKN, 5LGQ, 3KUJ, 3KTP, 2K8G, 5DX8, 1CVJ, 5DX1, 3KUI, 5LGP, 3KUT, 1JH4, 4F26

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H074 PAIP1	1	PAIP1 [cytosol] (R-HSA-429861)	0.966	20
UniProt:Q9HCJ0 TNRC6C	1	TNRC6C [cytosol] (R-HSA-427776)	0.941	22
UniProt:Q9BPZ3 PAIP2			0.86	15
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.855	8
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.835	6
UniProt:Q99700 ATX2			0.822	8
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.798	5
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.789	10
UniProt:Q58A45 PAN3	1	PAN3 [cytosol] (R-HSA-429938)	0.704	4
UniProt:P15130 NCAP			0.697	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.662	9
UniProt:Q14106 TOB2			0.656	5
UniProt:Q9UPQ9 TNRC6B	1	TNRC6B [cytosol] (R-HSA-427777)	0.656	3
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.643	6
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.623	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.564	3
UniProt:P50616 TOB1			0.558	4
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.558	5
UniProt:Q99700-5 Q997005			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.544	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P33469 NCAP			0.527	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.527	4
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q15366 PCBP2	2	PCBP2 [nucleoplasm] (R-HSA-71921) PCBP2 [cytosol] (R-HSA-983457)	0.527	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.527	2
UniProt:O55778 PHOSP			0.524	2
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.499	2
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:P0C6U8-PRO_0000338257			0.499	2
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.499	2
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.499	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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