Based on structural and functional studies of PIK3CA E542K mutant (Miled et al. 2007), substitution of glutamic acid residue at position 542 of PIK3CA with glutamine is expected to disrupt inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1, resulting in constitutive activity of the PI3K complex containing PIK3CA E542Q mutant.
Inbar, Y, Miled, N, Hon, WC, Williams, RL, Yan, Y, Backer, JM, Zvelebil, M, Wolfson, HJ, Schneidman-Duhovny, D, Perisic, O
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