Reactome | p-2S,S376,T,T209,T387-IRAK1 [cytosol]

p-2S,S376,T,T209,T387-IRAK1 [cytosol]

Stable Identifier

R-HSA-446682

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-6T-IRAK1, hp-IRAK1, Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN, IRAK1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
        
        Activated TAK complexes [cytosol] (Homo sapiens)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Homo sapiens)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Homo sapiens)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Homo sapiens)
        
        p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51617 IRAK1

Gene Names

IRAK1, IRAK

Chain

chain:1-712

Reference Genes

COSMIC (genes):IRAK1 IRAK1

dbSNP Gene:3654 IRAK1

ENSEMBL:ENSG00000184216 IRAK1

Participates

as a component of

as a member of

p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] (Homo sapiens)

Other forms of this molecule

IRAK1 [cytosol]

p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

p-T209,T387-IRAK1 [plasma membrane]

p-T209-IRAK1 [plasma membrane]

IRAK1 [plasma membrane]

p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]

IRAK1 [endosome membrane]

p-T209,T387-IRAK1 [endosome membrane]

p-T209-IRAK1 [endosome membrane]

K63polyUb-hp-IRAK1 [cytosol]

p-S376,T387-IRAK1 [cytosol]

K63polyUb-hp-IRAK1 [endosome membrane]

p-S,T-IRAK1 [cytosol]

Inferred To

phospho-IRAK1 [cytosol] (Canis familiaris)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Bos taurus)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Caenorhabditis elegans)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Dictyostelium discoideum)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Drosophila melanogaster)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Mus musculus)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Rattus norvegicus)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Sus scrofa)

Homologues of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Danio rerio)

Ghost homologue of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Gallus gallus)

Ghost homologue of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 387

Coordinate

387

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 376

Coordinate

376

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 209

Coordinate

209

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.77	4
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.743	4
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.734	4
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.723	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.645	10
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.623	3
UniProt:Q8N2H9-2 PELI3			0.589	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.564	3
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.564	3
UniProt:Q9NWZ3 IRAK4	9	IRAK4 [cytosol] (R-HSA-166081) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 E402* [cytosol] (R-HSA-5602517) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 Q293* [cytosol] (R-HSA-5602426)	0.547	2
UniProt:Q5D1E7	1	ZC3H12A [nucleoplasm] (R-MMU-9774235)	0.544	3
UniProt:Q96EY1 DNJA3			0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	2
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.527	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.527	2
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.499	2
UniProt:Q92985 IRF7	5	IRF7 [cytosol] (R-HSA-450281) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154)	0.499	2
UniProt:Q15306 IRF4	2	IRF4 [nucleoplasm] (R-HSA-9907101) IRF4 [cytosol] (R-HSA-1015679)	0.499	2
UniProt:Q8VCW4	2	Unc93b1 [endoplasmic reticulum membrane] (R-MMU-1678930) Unc93b1 [Golgi membrane] (R-MMU-1679064)	0.499	2

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