Reactome | 3OHH216-RPL8 [nucleoplasm]

3OHH216-RPL8 [nucleoplasm]

Stable Identifier

R-HSA-9630976

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

3OHH216-60S ribosomal protein L8, RL8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62917 RPL8

Gene Names

RPL8

Chain

initiator methionine:, chain:2-257

Reference Genes

BioGPS Gene:6132 RPL8

COSMIC (genes):RPL8 RPL8

CTD Gene:6132 RPL8

dbSNP Gene:6132 RPL8

ENSEMBL:ENSG00000161016 RPL8

ENSEMBL_homo_sapiens_GENE:ENSG00000161016.18 RPL8

HGNC:10368 RPL8

KEGG Gene (Homo sapiens):6132 RPL8

Monarch:6132 RPL8

NCBI Gene:6132 RPL8

OMIM:604177 RPL8

UCSC:P62917 RPL8

Reference Transcript

Other Identifiers

11744120_a_at

11753565_x_at

11756258_x_at

17082873

200936_PM_at

200936_at

31505_at

3159041

3159042

3159044

3159049

3159050

3159051

3159053

3159054

3159055

3159057

3159058

3159059

3159060

3159062

3928439

6132

8153903

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0015934

GO:0016020

GO:0019843

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:0098794

GO:1990904

HMNXSV003000800

HMNXSV003004133

ILMN_1764721

ILMN_1811433

PH_hs_0010606

TC08001762.hg

Z28407_at

g4506662_3p_at

Participates

as an output of

RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Homo sapiens)

Other forms of this molecule

RPL8 [nucleoplasm]

RPL8 [cytosol]

Inferred To

RPL2A [nucleoplasm] (Saccharomyces cerevisiae)

rpl801 [nucleoplasm] (Schizosaccharomyces pombe)

RpL8 [nucleoplasm] (Drosophila melanogaster)

Homologues of 3OHH216-RPL8 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of 3OHH216-RPL8 [nucleoplasm] (Schizosaccharomyces pombe)

rpl802 [nucleoplasm] (Schizosaccharomyces pombe)

rpl803 [nucleoplasm] (Schizosaccharomyces pombe)

rpl-2 [nucleoplasm] (Caenorhabditis elegans)

Rpl8 [nucleoplasm] (Mus musculus)

Rpl8 [nucleoplasm] (Rattus norvegicus)

3OHH216-RPL8 [nucleoplasm] (Plasmodium falciparum)

rpl8 [nucleoplasm] (Danio rerio)

rpl8 [nucleoplasm] (Dictyostelium discoideum)

rpl8 [nucleoplasm] (Xenopus tropicalis)

RPL2B [nucleoplasm] (Saccharomyces cerevisiae)

RPL8 [nucleoplasm] (Bos taurus)

RPL8 [nucleoplasm] (Canis familiaris)

RPL8 [nucleoplasm] (Gallus gallus)

RPL8 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

modified L-histidine residue at 216

Coordinate

216

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

RefSeq

NP_150644.1, NP_000964.1, NP_001304711.1, NP_001304700.1

OpenTargets

ENSG00000161016

HPA

ENSG00000161016-RPL8

GeneCards

P62917

Ensembl

ENSG00000161016, ENST00000262584, ENST00000528957, ENST00000394920, ENSP00000262584, ENSP00000378378, ENSP00000433464

PRO

P62917

Pharos - Targets

P62917

PDB

5LKS, 4V6X, 6Z6N, 6W6L, 6OLI, 8OHD, 8IR3, 6Z6M, 6LU8, 6LQM, 4CCO, 8INK, 8IR1, 8FLF, 5T2C, 8INF, 6IP8, 6OLG, 6Z6L, 8FLE, 6OLF, 8FLD, 6OLZ, 8IE3, 4CCM, 6OM0, 5AJ0, 8JDJ, 8FL6, 8FL4, 6OLE, 6OM7, 8IDY, 7XNY, 7XNX, 8A3D, 6XA1, 8IDT, 7UN3, 6Y0G, 8JDM, 6Y6X, 6LSR, 6LSS, 8FL9, 8OJ5, 6ZM7, 8OJ0, 8JDK, 4Y3O, 8IPD, 6Y57, 8JDL, 6ZMO, 7OW7, 8FL7, 6QZP, 8IFE, 6Y2L, 8IPY, 6IP6, 6IP5, 6ZMI, 8INE, 8FLC, 8Y0X, 4UG0, 8QFD, 4CCN, 8Y0W, 8FKZ, 8FLB, 8FLA, 8IFD, 8IPX, 8OJ8, 7BHP, 8FL3, 6ZME, 8FL2, 7F5S

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	20
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.528	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:P42696 RBM34			0.527	3
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	2
UniProt:P51608 MECP2			0.527	3
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15397 PUM3			0.527	3
UniProt:Q6PK04 CC137			0.527	2
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:Q13823 NOG2			0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q96ME7 ZN512			0.527	3
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q8NDF8 PAPD5			0.527	3
UniProt:O43167 ZBT24			0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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