Reactome | SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]

SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sequestosome-1, SQSTM_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21134980	Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma Takeuchi, K, Soda, M, Togashi, Y, Ota, Y, Sekiguchi, Y, Hatano, S, Asaka, R, Noguchi, M, Mano, H	Haematologica	2011
25813404	Novel ALK fusion partners in lung cancer Iyevleva, AG, Raskin, GA, Tiurin, VI, Sokolenko, AP, Mitiushkina, NV, Aleksakhina, SN, Garifullina, AR, Strelkova, TN, Merkulov, VO, Ivantsov, AO, Kuligina, ESh, Pozharisski, KM, Togo, AV, Imyanitov, EN	Cancer Lett	2015

External Reference Information

External Reference

UniProt:Q13501 SQSTM1

Gene Names

SQSTM1, ORCA, OSIL

Chain

initiator methionine:1, chain:2-440, initiator methionine:1

Reference Genes

BioGPS Gene:8878 SQSTM1

COSMIC (genes):SQSTM1 SQSTM1

CTD Gene:8878 SQSTM1

dbSNP Gene:8878 SQSTM1

ENSEMBL:ENSG00000161011 SQSTM1

HGNC:11280 SQSTM1

KEGG:hsa:8878 SQSTM1

Monarch:8878 SQSTM1

NCBI Entrez Gene:8878 SQSTM1

OMIM:601530 SQSTM1

UCSC:Q13501 SQSTM1

Reference Transcript

Other Identifiers

11717290_s_at

11727031_a_at

11745754_x_at

11752843_x_at

11756761_x_at

16993458

201471_PM_s_at

201471_s_at

213112_PM_s_at

213112_s_at

235530_PM_at

235530_at

239004_PM_at

239004_at

242568_PM_s_at

242568_s_at

244804_PM_at

244804_at

2844480

2844481

2844482

2844484

2844485

2844486

2844487

2844488

2844489

2844498

2844499

2844500

2844503

2844504

2844505

2844506

2844507

2844508

2844509

2844511

2844512

2844513

2844514

2844515

2844516

2844517

2844518

2844519

2844520

2844523

2844524

2844525

2844526

2844527

2844528

2844529

2844535

2844536

2844537

2844538

2844539

2844540

2844541

2844542

40898_at

54456_at

8110569

8878

A_14_P109999

A_23_P81399

A_24_P612020

GE79794

GO:0000122

GO:0000407

GO:0000422

GO:0000423

GO:0000425

GO:0000932

GO:0001659

GO:0002376

GO:0002931

GO:0005080

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005776

GO:0005783

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0006511

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0006915

GO:0007032

GO:0008104

GO:0008270

GO:0010508

GO:0010821

GO:0016192

GO:0016197

GO:0016234

GO:0016235

GO:0016236

GO:0016605

GO:0019899

GO:0019901

GO:0030017

GO:0030154

GO:0030163

GO:0030674

GO:0030971

GO:0031397

GO:0031410

GO:0031625

GO:0033554

GO:0034142

GO:0034144

GO:0035255

GO:0035556

GO:0035591

GO:0035973

GO:0038023

GO:0042169

GO:0042802

GO:0043065

GO:0043122

GO:0043130

GO:0043226

GO:0043232

GO:0044753

GO:0044754

GO:0044877

GO:0045202

GO:0045944

GO:0046578

GO:0046872

GO:0060090

GO:0061635

GO:0070062

GO:0070342

GO:0070530

GO:0070534

GO:0071211

GO:0097009

GO:0097225

GO:0097413

GO:0098780

GO:0098978

GO:0110076

GO:0140036

GO:0140311

GO:0140313

GO:0140693

GO:0140694

GO:1900273

GO:1903078

GO:1905719

HMNXSV003033729

Hs.152454.0.A1_3p_at

Hs.252782.0.A1_3p_at

Hs.279891.1.A1_3p_at

Hs.97259.0.A1_3p_at

Hs.97259.1.S1_3p_a_at

Hs.97259.1.S1_3p_x_at

ILMN_1662618

PH_hs_0010763

U46751_at

g4505570_3p_s_at

Participates

as a component of

SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

SQSTM1 [cytosol]

SQSTM1 [nucleoplasm]

ub K420 p-S349 SQSTM1 [cytosol]

p-S349 SQSTM1 [cytosol]

K7 ub-SQSTM1 [cytosol]

SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 252 from UniProt:Q9UM73 ALK

Coordinate

252

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
diffuse large B-cell lymphoma	DOID:0050745
lung adenocarcinoma	DOID:3910	nonsmall cell adenocarcinoma

Cross References

RefSeq

NP_001135771.1, NP_003891.1, NP_001135770.1, XP_016865499.1

Guide to Pharmacology - Targets

3213

OpenTargets

ENSG00000161011

ENSEMBL

ENST00000643389, ENSP00000491834, ENST00000389805, ENSP00000495843, ENSP00000353944, ENSG00000161011, ENST00000360718, ENSG00000284099, ENSP00000374455, ENST00000640444

Mondo

0018905, 0005061

PRO

Q13501

GlyGen

Q13501

PDB

2K0B, 4UF9, 5YPC, 5YPH, 5YPB, 4UF8, 2JY8, 2JY7, 4MJS, 2KNV, 1Q02, 6TH3, 6TGY, 6MJ7, 5YP7, 5YPE, 5YP8, 6KHZ, 5YPG, 5YPF, 7R1O, 6JM4, 5YPA

COSMIC

COSF1051

GeneCards

SQSTM1

HPA

ENSG00000161011-SQSTM1

Pharos - Targets

Q13501

Orphanet

SQSTM1

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.978	31
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.97	25
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.967	21
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.953	18
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A [cytosol] (R-HSA-5205676) MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [autophagosome membrane] (R-HSA-5683640)	0.951	16
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.948	17
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [cytosol] (R-HSA-5679223) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [autophagosome membrane] (R-HSA-5683638)	0.901	8
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.894	11
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.888	10
IntAct:EBI-4399559 UBIQ			0.829	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122)	0.806	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.801	8
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.775	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.771	11
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.728	9
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.725	6
UniProt:Q8IZQ1 WDFY3			0.709	7
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.688	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.67	18
UniProt:Q15038 DAZP2			0.666	4
UniProt:P54253 ATX1			0.666	4
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.666	5
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.666	4
UniProt:Q9BPW8 NIPS1			0.65	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.635	3
UniProt:P11473 VDR	2	VDR [nucleoplasm] (R-HSA-375512) polySUMO2-VDR [nucleoplasm] (R-HSA-4546376)	0.591	4
UniProt:Q6IRU7	1	Cep78 [cytosol] (R-MMU-380304)	0.564	2
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.558	7
UniProt:Q9UGJ0 PRKAG2	3	PRKAG2 [endoplasmic reticulum lumen] (R-HSA-9931280) PRKAG2 [nucleoplasm] (R-HSA-164130) PRKAG2 [cytosol] (R-HSA-200419)	0.556	3
UniProt:O14682 ENC1			0.556	7
UniProt:O14576-2 O145762			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:P34972 CNR2	1	CNR2 [plasma membrane] (R-HSA-419372)	0.556	5
UniProt:P19544-6 WT1			0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [cytosol] (R-HSA-6792602) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [nucleoplasm] (R-HSA-6792605)	0.556	3
UniProt:P12709	4	GPI [ficolin-1-rich granule lumen] (R-SCE-6801506) GPI [extracellular region] (R-SCE-6806478) GPI [secretory granule lumen] (R-SCE-6801495) GPI [cytosol] (R-SCE-70468)	0.556	3
UniProt:A8K2U6 A8K2U6			0.556	3
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	6
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q2V2M9 FHOD3			0.543	6
UniProt:Q2V2M9-4 FHOD3			0.543	4
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.543	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.537	3
UniProt:P57739 CLDN2	2	CLDN2 [plasma membrane] (R-HSA-419994) CLDN2 [cell junction] (R-HSA-421235)	0.537	4
UniProt:P46098 HTR3A	1	HTR3A [plasma membrane] (R-HSA-975301)	0.527	2
UniProt:Q96DN2 VWCE			0.527	2
UniProt:Q9NT22 EMILIN3	1	EMILIN3 [extracellular region] (R-HSA-2161272)	0.527	2
UniProt:Q15334 L2GL1			0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	3
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.527	2
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.524	4
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.524	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.524	2
UniProt:P38182	12	ATG8 [cytosol] (R-SCE-5205651) ATG8 [cytosol] (R-SCE-5205676) ATG8 [cytosol] (R-SCE-975521) ATG8 [cytosol] (R-SCE-5679223) ATG8 [cytosol] (R-SCE-5682696) ATG8 [cytosol] (R-SCE-5682674) ATG8 [cytosol] (R-SCE-5682653) ATG8 [cytosol] (R-SCE-5682681) ATG8 [autophagosome membrane] (R-SCE-5683634) ATG8 [autophagosome membrane] (R-SCE-5683638) ATG8 [autophagosome membrane] (R-SCE-5683640) ATG8 [autophagosome membrane] (R-SCE-5683641)	0.508	3
UniProt:P12504 VIF			0.499	2
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.499	2
UniProt:O70405	7	ULK1 [recycling endosome] (R-MMU-8854761) phospho-p-S758-ULK1 [cytosol] (R-MMU-5672131) phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (R-MMU-5673747) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-MMU-5675858) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-MMU-8948047) ULK1 [mitochondrial outer membrane] (R-MMU-8948145) ULK1 [cytosol] (R-MMU-1632847)	0.499	2
UniProt:Q9NX00 TM160			0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	14

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