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phospho-Irs1 [plasma membrane]
Stable Identifier
R-RNO-198366
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
p-Y-IRS1, P35570
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Rattus norvegicus)
phospho-Irs1 [plasma membrane] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Rattus norvegicus)
phospho-Irs1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P35570 Irs1
Gene Names
Irs1, Irs-1
Chain
chain:1-1235
Reference Genes
BioGPS Gene:25467 Irs1
KEGG Gene (Rattus norvegicus):25467 Irs1
Monarch:25467 Irs1
NCBI Gene:25467 Irs1
UCSC:P35570 Irs1
Reference Transcript
RefSeq:NM_012969.1 Irs1
Participates
as a member of
Phospho-IRS1/2 (by TRKA) [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Irs1 [cytosol]
phospho-Irs1 [plasma membrane]
Irs1 [plasma membrane]
p-Y-Irs1 [cytosol]
Irs1 [cytosol]
phospho-Irs1 [cytosol]
Inferred From
p-Y-IRS1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_037101.1
PRO
P35570
RGD
2922
PDB
5WRK
,
5WRL
,
5WRM
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.791
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.737
5
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.656
3
UniProt:Q63787 Pik3r1
4
Pik3r1 [cytosol]
(R-RNO-3080572)
Pi3k-p85 [cytosol]
(R-RNO-912643)
Pik3r1 [cytosol]
(R-RNO-74789)
Pik3r1 [plasma membrane]
(R-RNO-198365)
0.589
2
UniProt:Q13625-2 TP53BP2
0.567
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.564
2
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.525
3
UniProt:Q8VDD9
1
Phip [cytosol]
(R-MMU-9715153)
0.508
2
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
(R-MMU-9032530)
pFyn (420) [cytosol]
(R-MMU-420335)
pFyn(Y531) [cytosol]
(R-MMU-420350)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
0.462
4
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