Reactome | RABGEF1 [early endosome membrane]

RABGEF1 [early endosome membrane]

Stable Identifier

R-HSA-2029032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Rabex5, Rab5 GDP/GTP exchange factor, RABX5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UJ41 RABGEF1

Gene Names

RABGEF1, RABEX5

Chain

chain:1-491

Reference Genes

BioGPS Gene:27342 RABGEF1

COSMIC (genes):RABGEF1 RABGEF1

CTD Gene:27342 RABGEF1

dbSNP Gene:27342 RABGEF1

ENSEMBL:ENSG00000154710 RABGEF1

ENSEMBL_homo_sapiens_GENE:ENSG00000154710.18 RABGEF1

HGNC:17676 RABGEF1

KEGG Gene (Homo sapiens):27342 RABGEF1

Monarch:27342 RABGEF1

NCBI Gene:27342 RABGEF1

OMIM:609700 RABGEF1

UCSC:Q9UJ41 RABGEF1

Reference Transcript

Other Identifiers

11742970_at

11748733_a_at

17046683

17124746

218310_PM_at

218310_at

27342

3005746

3005750

3005752

3005753

3005757

3005758

3005759

3005762

3005764

3005765

3005766

3005767

3005768

3053802

3053803

3053974

3053976

3053988

3053989

3053993

3057603

3057607

3057608

3057609

3057610

45273_at

8133176

A_14_P138299

A_21_P0013322

A_23_P250825

A_24_P232049

A_24_P337746

GE61693

GO:0001933

GO:0002376

GO:0002686

GO:0003677

GO:0003824

GO:0005085

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0006612

GO:0006886

GO:0006897

GO:0006898

GO:0006954

GO:0007018

GO:0007265

GO:0008270

GO:0015031

GO:0016192

GO:0016740

GO:0023052

GO:0030139

GO:0030425

GO:0031267

GO:0031410

GO:0031901

GO:0031982

GO:0032715

GO:0032764

GO:0033004

GO:0036211

GO:0038109

GO:0043226

GO:0043303

GO:0043305

GO:0046580

GO:0046872

GO:0048261

GO:0048870

GO:0050728

GO:0051649

GO:0055037

GO:0060368

GO:0061630

GO:0097531

GO:0098772

GO:0098935

GO:0140096

GO:1900235

HMNXSV003023640

ILMN_2230577

ILMN_2230579

PH_hs_0010985

TC07003328.hg

g7657495_3p_at

Participates

as a component of

GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)

Other forms of this molecule

RABGEF1 [cytosol]

Inferred To

Rabex-5 [early endosome membrane] (Drosophila melanogaster)

RABGEF1 [early endosome membrane] (Gallus gallus)

RABGEF1 [early endosome membrane] (Sus scrofa)

rabx-5 [early endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001273991.1, NP_001273990.1, NP_001273989.1, NP_055319.1

OpenTargets

ENSG00000154710

HPA

ENSG00000154710-RABGEF1

GeneCards

Q9UJ41

Ensembl

ENSP00000415815, ENSP00000284957, ENST00000284957, ENST00000450873, ENSG00000154710

PRO

Q9UJ41

Pharos - Targets

Q9UJ41

HMDB Protein

HMDBP08515

PDB

2C7M, 4N3X, 4N3Z, 4Q9U, 2OT3, 1TXU, 4N3Y, 2C7N

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.749	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.643	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.632	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.599	4
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3

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