PTEN missense mutation that results in the substitution of histidine at position 93 with tyrosine affects the phosphatase domain of PTEN. PTEN H93Y (His93Tyr) mutant shows markedly decreased phosphoinositide phosphatase activity (Han et al. 2000).
Han, SY, Kato, H, Kato, S, Suzuki, T, Shibata, H, Ishii, S, Shiiba, K, Matsuno, S, Kanamaru, R, Ishioka, C
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