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DNM1L [mitochondrial outer membrane]
Stable Identifier
R-HSA-351942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Drp1
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Mitochondrial recruitment of Drp1 (Homo sapiens)
DNM1L [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00429 DNM1L
Gene Names
DNM1L, DLP1, DRP1
Chain
chain:1-736
Reference Genes
BioGPS Gene:10059 DNM1L
COSMIC (genes):DNM1L DNM1L
CTD Gene:10059 DNM1L
dbSNP Gene:10059 DNM1L
ENSEMBL:ENSG00000087470 DNM1L
ENSEMBL_homo_sapiens_GENE:ENSG00000087470.21 DNM1L
HGNC:2973 DNM1L
KEGG Gene (Homo sapiens):10059 DNM1L
Monarch:10059 DNM1L
NCBI Gene:10059 DNM1L
OMIM:603850 DNM1L
UCSC:O00429 DNM1L
Reference Transcript
RefSeq:NM_001278464.1 DNM1L
RefSeq:NM_001278466.1 DNM1L
RefSeq:NM_001278463.1 DNM1L
RefSeq:NM_005690.4 DNM1L
RefSeq:NM_001278465.1 DNM1L
RefSeq:NM_012063.3 DNM1L
RefSeq:NM_001330380.1 DNM1L
RefSeq:NM_012062.4 DNM1L
Other Identifiers
10059
11737604_a_at
11742435_a_at
11743371_x_at
11750026_a_at
16749826
203105_PM_s_at
203105_s_at
226154_PM_at
226154_at
3410696
3410697
3410703
3410707
3410709
3410711
3410713
3410714
3410717
3410721
3410722
3410723
3410727
3410728
3410731
3410732
3410734
3410735
3410737
3410739
3410740
3410742
3410743
3410744
3410745
3410746
3410747
3410748
3410749
3410750
357_at
41201_at
44814_s_at
63887_at
7954752
AF000430_at
A_23_P204324
A_24_P176044
A_24_P743907
GE81541
GO:0000166
GO:0000266
GO:0001836
GO:0002376
GO:0003013
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005525
GO:0005737
GO:0005739
GO:0005741
GO:0005777
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005903
GO:0005905
GO:0006816
GO:0006897
GO:0006914
GO:0007005
GO:0007031
GO:0008017
GO:0008092
GO:0008289
GO:0010468
GO:0010821
GO:0012501
GO:0012505
GO:0016020
GO:0016192
GO:0016559
GO:0016787
GO:0023052
GO:0030672
GO:0030742
GO:0031267
GO:0031410
GO:0031625
GO:0032991
GO:0042802
GO:0042803
GO:0043065
GO:0043226
GO:0043231
GO:0043653
GO:0045202
GO:0048312
GO:0048471
GO:0048511
GO:0048856
GO:0048870
GO:0050714
GO:0051179
GO:0051259
GO:0055086
GO:0060047
GO:0060090
GO:0061024
GO:0061025
GO:0065003
GO:0070266
GO:0070585
GO:0090023
GO:0090141
GO:0090149
GO:0090200
GO:0098772
GO:0099073
GO:0160040
GO:1900063
GO:1901135
GO:1901524
GO:1903578
GO:2001244
HMNXSV003031208
Hs.180628.4.A1_3p_at
ILMN_1685260
ILMN_1724826
ILMN_2286800
PH_hs_0010688
TC12000298.hg
g6996004_3p_a_at
Participates
as an output of
Mitochondrial recruitment of Drp1 (Homo sapiens)
Other forms of this molecule
DNM1L [cytosol]
Inferred To
DNM1L [mitochondrial outer membrane]
(Bos taurus)
DNM1L [mitochondrial outer membrane]
(Canis familiaris)
DNM1L [mitochondrial outer membrane]
(Danio rerio)
DNM1L [mitochondrial outer membrane]
(Dictyostelium discoideum)
DNM1L [mitochondrial outer membrane]
(Gallus gallus)
DNM1L [mitochondrial outer membrane]
(Mus musculus)
DNM1L [mitochondrial outer membrane]
(Plasmodium falciparum)
DNM1L [mitochondrial outer membrane]
(Rattus norvegicus)
DNM1L [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
DNM1L [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
DNM1L [mitochondrial outer membrane]
(Sus scrofa)
LOC119868890 [mitochondrial outer membrane]
(Canis familiaris)
Homologues of DNM1L [mitochondrial outer membrane]
(Canis familiaris)
drp-1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
Drp1 [mitochondrial outer membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_036193.2
,
NP_001317309.1
,
NP_001265394.1
,
NP_036192.2
,
NP_001265392.1
,
NP_001265393.1
,
NP_001265395.1
,
NP_005681.2
OpenTargets
ENSG00000087470
GeneCards
O00429
HPA
ENSG00000087470-DNM1L
Ensembl
ENSP00000450399
,
ENST00000549701
,
ENST00000358214
,
ENST00000553257
,
ENST00000381000
,
ENSP00000370388
,
ENSP00000350948
,
ENSP00000449089
,
ENSP00000266481
,
ENST00000452533
,
ENSP00000448610
,
ENST00000547312
,
ENSG00000087470
,
ENSP00000415131
,
ENST00000266481
PRO
O00429
Pharos - Targets
O00429
Orphanet
22019
PDB
8T1H
,
4H1U
,
3W6N
,
4H1V
,
3W6P
,
4BEJ
,
3W6O
,
5WP9
HMDB Protein
HMDBP08349
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.91
16
UniProt:Q96C03 MID49
0.696
5
UniProt:Q9NQG6 MID51
0.693
11
UniProt:Q9NVI7-2 ATAD3A
0.645
5
UniProt:Q9GZY8 MFF
0.641
3
UniProt:O00429 DNM1L
2
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
DNM1L [cytosol]
(R-HSA-351943)
0.609
2
UniProt:Q9Y512 SAMM50
1
SAMM50 [mitochondrial outer membrane]
(R-HSA-1252178)
0.602
3
UniProt:P12532 CKMT1A
1
CKMT1A [mitochondrial inner membrane]
(R-HSA-200361)
0.527
3
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
2
UniProt:Q8NC51 SERB1
0.527
3
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.527
5
UniProt:Q9NVI7 ATD3A
0.499
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.483
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.483
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
4
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
3
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