Reactome | PPP2R1A [nucleoplasm]

PPP2R1A [nucleoplasm]

Stable Identifier

R-HSA-165968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-subunit A alpha isoform

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1A [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1A [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1A [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30153 PPP2R1A

Gene Names

PPP2R1A

Chain

initiator methionine:, chain:2-589

Reference Genes

BioGPS Gene:5518 PPP2R1A

COSMIC (genes):PPP2R1A PPP2R1A

CTD Gene:5518 PPP2R1A

dbSNP Gene:5518 PPP2R1A

ENSEMBL:ENSG00000105568 PPP2R1A

ENSEMBL_homo_sapiens_GENE:ENSG00000105568.19 PPP2R1A

HGNC:9302 PPP2R1A

KEGG Gene (Homo sapiens):5518 PPP2R1A

Monarch:5518 PPP2R1A

NCBI Gene:5518 PPP2R1A

OMIM:605983 PPP2R1A

UCSC:P30153 PPP2R1A

Reference Transcript

RefSeq:NM_014225.5 PPP2R1A

Other Identifiers

11747739_a_at

11747740_x_at

11749158_a_at

11755561_x_at

11756949_a_at

16864778

200695_PM_at

200695_at

3840059

3840060

3840065

3840066

3840067

3840069

3840070

3840072

3840074

3840075

3840076

3840078

3840079

3840080

3840081

3840082

3840083

3840085

3840087

3840088

3840089

3840097

3840099

3840100

3840101

40867_at

5518

8030881

922_at

A_14_P110884

GO:0000159

GO:0000278

GO:0000775

GO:0002376

GO:0003824

GO:0004722

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0006260

GO:0006275

GO:0006351

GO:0006355

GO:0006470

GO:0006629

GO:0006672

GO:0006915

GO:0007010

GO:0007059

GO:0007143

GO:0007155

GO:0008380

GO:0010033

GO:0012501

GO:0015630

GO:0016020

GO:0016328

GO:0016787

GO:0019888

GO:0019932

GO:0022414

GO:0023052

GO:0030111

GO:0030154

GO:0030155

GO:0030308

GO:0030425

GO:0036211

GO:0040008

GO:0042532

GO:0042995

GO:0043005

GO:0043025

GO:0043029

GO:0043226

GO:0043409

GO:0045202

GO:0045595

GO:0046982

GO:0048856

GO:0051232

GO:0051306

GO:0051754

GO:0051898

GO:0065003

GO:0070062

GO:0098772

GO:0098978

GO:0140013

GO:0140014

GO:0140096

GO:1903538

GO:1990405

GO:2001241

ILMN_1810467

J02902_at

PH_hs_0010422

TC19000792.hg

TC19002217.hg

g7657474_3p_at

Participates

as a candidate of

PP2A-subunit A [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PPP2R1A [cytosol]

Inferred To

TPD3 [nucleoplasm] (Saccharomyces cerevisiae)

paa-1 [nucleoplasm] (Caenorhabditis elegans)

ppp2r1bb [nucleoplasm] (Danio rerio)

pppA [nucleoplasm] (Dictyostelium discoideum)

Pp2A-29B [nucleoplasm] (Drosophila melanogaster)

ppp2r1a [nucleoplasm] (Xenopus tropicalis)

paa1 [nucleoplasm] (Schizosaccharomyces pombe)

PPP2R1A [nucleoplasm] (Bos taurus)

PPP2R1A [nucleoplasm] (Canis familiaris)

PPP2R1A [nucleoplasm] (Sus scrofa)

Ppp2r1a [nucleoplasm] (Mus musculus)

Ppp2r1a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_055040.2

OpenTargets

ENSG00000105568

HPA

ENSG00000105568-PPP2R1A

GeneCards

P30153

Ensembl

ENSG00000105568, ENST00000322088, ENSP00000324804

PRO

P30153

Pharos - Targets

P30153

Orphanet

23797

PDB

4LAC, 8U89, 3K7V, 4I5N, 7PKS, 8SO0, 8RC4, 2IE3, 8U1X, 2NYM, 6NTS, 6IUR, 3K7W, 7CUN, 7SOY, 2PKG, 2IE4, 2NPP, 3C5W, 7YCX, 8TWE, 8RBX, 3DW8, 8UWB, 7K36, 8TWI, 4I5L, 8TTB, 5W0W, 1B3U, 2NYL, 8RBZ

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.984	50
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.953	20
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.944	15
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.889	24
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.848	10
UniProt:Q86XL3 ANKLE2	2	ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000) Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946)	0.807	7
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.788	5
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.745	7
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.744	4
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.742	6
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.671	7
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.643	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.628	3
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.591	3
UniProt:P42285 SKIV2L2	1	SKIV2L2 [nucleoplasm] (R-HSA-6791189)	0.569	3
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.564	3
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.564	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.544	2
UniProt:O55106	1	Strn [cytosol] (R-MMU-9037081)	0.536	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	3
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.524	3
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.508	2
UniProt:P51809 VAMP7	6	VAMP7 [late endosome membrane] (R-HSA-2193120) VAMP7 [lysosomal membrane] (R-HSA-376342) VAMP7 [plasma membrane] (R-HSA-376361) VAMP7 [Golgi membrane] (R-HSA-266197) VAMP7 [cytoplasmic vesicle membrane] (R-HSA-376336) VAMP7 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869135)	0.508	2
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.499	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.499	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.462	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.462	2

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