Reactome | MCRS1 [nucleoplasm]

MCRS1 [nucleoplasm]

Stable Identifier

R-HSA-3321849

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Microspherule protein 1, MCRS1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96EZ8 MCRS1

Gene Names

MCRS1, INO80Q, MSP58

Chain

chain:1-462

Reference Genes

BioGPS Gene:10445 MCRS1

COSMIC (genes):MCRS1 MCRS1

CTD Gene:10445 MCRS1

dbSNP Gene:10445 MCRS1

ENSEMBL:ENSG00000187778 MCRS1

ENSEMBL:ENSG00000187778.14 MCRS1

HGNC:6960 MCRS1

KEGG Gene (Homo sapiens):10445 MCRS1

Monarch:10445 MCRS1

NCBI Gene:10445 MCRS1

OMIM:609504 MCRS1

UCSC:Q96EZ8 MCRS1

Reference Transcript

Other Identifiers

10445

11718162_a_at

16764348

202556_PM_s_at

202556_s_at

33898_at

3453905

3453906

3453908

3453910

3453912

3453914

3453916

3453917

3453920

3453921

3453922

3453923

3453925

3453926

3453928

3453929

3453930

3453933

3453934

3453937

7963064

A_23_P48237

GE81623

GO:0000123

GO:0000228

GO:0000723

GO:0002151

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005844

GO:0006260

GO:0006275

GO:0006281

GO:0006282

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006974

GO:0008266

GO:0010521

GO:0030425

GO:0031011

GO:0032200

GO:0033044

GO:0034046

GO:0036211

GO:0043204

GO:0043226

GO:0043981

GO:0043982

GO:0043984

GO:0044545

GO:0045739

GO:0045893

GO:0045944

GO:0045995

GO:0048856

GO:0051571

GO:0051726

GO:0051974

GO:0060382

GO:0071339

GO:0098772

GO:1900095

GO:1904357

GO:1904507

GO:1904751

HMNXSV003025875

ILMN_1713147

ILMN_1784227

PH_hs_0002226

TC12001478.hg

TC12002870.hg

g5453693_3p_a_at

Participates

as a component of

as an input of

Formation of the NSL complex (Homo sapiens)

Inferred To

Mcrs1 [nucleoplasm] (Mus musculus)

Mcrs1 [nucleoplasm] (Rattus norvegicus)

MCRS1 [nucleoplasm] (Bos taurus)

MCRS1 [nucleoplasm] (Canis familiaris)

MCRS1 [nucleoplasm] (Gallus gallus)

MCRS1 [nucleoplasm] (Sus scrofa)

mcrs1 [nucleoplasm] (Xenopus tropicalis)

wu:fj97a11 [nucleoplasm] (Danio rerio)

Rcd5 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_006328.2, XP_016874179.1, NP_001012300.1, NP_001265270.1, XP_005268629.1, XP_016874178.1

OpenTargets

ENSG00000187778

GeneCards

Q96EZ8

HPA

ENSG00000187778-MCRS1

Ensembl

ENST00000357123, ENST00000546244, ENSG00000187778, ENST00000550165, ENSP00000349640, ENSP00000448056, ENST00000343810, ENSP00000444982, ENSP00000345358

PRO

Q96EZ8

Pharos - Targets

Q96EZ8

Interactors (120)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C0 WASC3			0.879	13
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.8	8
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.793	11
UniProt:O15209 ZBT22			0.718	6
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:Q86WP2 GPBP1			0.696	5
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.696	5
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.671	4
UniProt:Q9C0F1 CEP44			0.666	6
UniProt:P51116 FXR2			0.666	4
UniProt:P57055 DSCR6			0.666	4
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.666	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.666	4
UniProt:Q9BQD3 KXDL1			0.666	4
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.621	3
UniProt:Q9D1P2	1	KAT8 [nucleoplasm] (R-MMU-3321802)	0.564	2
UniProt:Q6NT76 HMBX1			0.556	8
UniProt:O60759 CYTIP			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:P38432 COIL			0.556	3
UniProt:Q86TJ2-3 Q86TJ23			0.556	3
UniProt:P19237 TNNI1	1	TNNI1 [cytosol] (R-HSA-390539)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
UniProt:Q8N137 CNTRB			0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q96KB5 TOPK			0.556	3
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.556	3
UniProt:O60861-1 GAS7			0.556	3
UniProt:Q14919 DRAP1	1	DRAP1 [nucleoplasm] (R-HSA-1226029)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:Q86VR2 RETR3			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8N302 AGGF1	2	AGGF(1-290)-RAF1(279-648) fusion [cytosol] (R-HSA-6802255) AGGF(1-290)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802507)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9H0E9-2 BRD8			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q5PSV4 BRM1L			0.556	5
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.556	3
UniProt:O75971-2 SNAPC5			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
UniProt:Q2T9L4 INSY1			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:P50548 ERF	3	ERF [nucleoplasm] (R-HSA-2534321) p-T526-ERF [cytosol] (R-HSA-3209167) p-T526-ERF [nucleoplasm] (R-HSA-3209166)	0.556	3
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.556	3
UniProt:Q01664 TFAP4			0.556	3
UniProt:Q9H2S9 IKZF4			0.556	3
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.556	3
UniProt:Q8IYE1 CCD13			0.556	6
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
IntAct:EBI-23710320 CCSB ORF ID			0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q02446 SP4			0.556	3
UniProt:Q96GN5 CDA7L			0.556	6
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q8TC99 FNDC8			0.556	3
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.556	5
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.556	3
UniProt:Q5T5X7 BEND3			0.556	3
UniProt:Q8N344 MIER2			0.556	5
UniProt:Q96S65 CSRN1			0.556	3
UniProt:O95810 CAVN2			0.556	3
UniProt:O75420 GGYF1			0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q9H4L5 OSBPL3	1	OSBPL3 [cytosol] (R-HSA-8867532)	0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
IntAct:EBI-22395812 CCSB ORF ID			0.556	3
UniProt:P17098 ZNF8			0.556	3
UniProt:P41227 NAA10			0.556	3
IntAct:EBI-23624784 CCSB ORF ID			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q9UID6 ZN639			0.556	3
UniProt:Q8N8K9 K1958			0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	6
UniProt:Q96B23 CR025			0.556	5
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q15154-3 PCM1			0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P17027 ZNF23	1	ZNF23 [nucleoplasm] (R-HSA-1027395)	0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:O14492-2 O144922			0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:Q7RTU4 BHA09			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q7Z3K6-2 MIER3			0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.508	2

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