Reactome | UCHL5 [cytosol]

UCHL5 [cytosol]

Stable Identifier

R-HSA-1629778

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH37

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y5K5 UCHL5

Gene Names

UCHL5, UCH37, AD-019, CGI-70

Chain

chain:1-329

Reference Genes

BioGPS Gene:51377 UCHL5

COSMIC (genes):UCHL5 UCHL5

CTD Gene:51377 UCHL5

dbSNP Gene:51377 UCHL5

ENSEMBL:ENSG00000116750 UCHL5

HGNC:19678 UCHL5

KEGG:hsa:51377 UCHL5

Monarch:51377 UCHL5

NCBI Gene:51377 UCHL5

OMIM:610667 UCHL5

UCSC:Q9Y5K5 UCHL5

Reference Transcript

Participates

as a component of

ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)

as an input of

ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)

as a member of

UCHL5/USP15 [cytosol] (Homo sapiens)

Other forms of this molecule

UCHL5 [nucleoplasm]

Inferred To

uchl5 [cytosol] (Danio rerio)

uchl5 [cytosol] (Xenopus tropicalis)

Homologues of UCHL5 [cytosol] (Sus scrofa)

UCH54 [cytosol] (Plasmodium falciparum)

Uch-L5 [cytosol] (Drosophila melanogaster)

uch2 [cytosol] (Dictyostelium discoideum)

uch2 [cytosol] (Schizosaccharomyces pombe)

Uchl5 [cytosol] (Mus musculus)

Uchl5 [cytosol] (Rattus norvegicus)

UCHL5 [cytosol] (Bos taurus)

UCHL5 [cytosol] (Canis familiaris)

UCHL5 [cytosol] (Gallus gallus)

UCHL5 [cytosol] (Sus scrofa)

ubh-4 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001186190.1, NP_001186192.1, NP_001186191.1, NP_057068.1

OpenTargets

ENSG00000116750

ENSEMBL

ENST00000367449, ENST00000367448, ENSP00000356419, ENSP00000356424, ENSP00000356418, ENSG00000116750, ENST00000367454, ENSP00000356425, ENST00000367455

IntEnz

3.4.19.12

GeneCards

UCHL5

HPA

ENSG00000116750-UCHL5

ZINC - Substances

UCHL5_HUMAN

ZINC target

Q9Y5K5

PRO

Q9Y5K5

Pharos - Targets

Q9Y5K5

PDB

4UEL, 4UF6, 3TB3, 3RIS, 4UEM, 3A7S, 4WLP, 3RII, 4UF5, 3IHR

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.965	24
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.886	8
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.886	8
UniProt:Q6P4R8 NFRKB	1	NFRKB [nucleoplasm] (R-HSA-5689578)	0.885	15
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.857	8
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.837	8
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.837	9
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.837	7
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.837	7
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.837	8
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.837	7
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.837	7
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.837	7
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.823	11
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.788	7
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.788	6
UniProt:Q99460 PSMD1	4	PSMD1 [cytosol] (R-HSA-68786) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194)	0.788	6
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.788	7
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.788	6
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983)	0.788	7
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.773	7
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.744	5
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.725	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.725	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.725	5
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.725	5
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.725	5
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.725	4
UniProt:Q9H981 ACTR8	1	ACTR8 [nucleoplasm] (R-HSA-5689565)	0.708	5
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	4
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.643	4
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.643	4
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.643	4
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.643	4
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.643	3
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.643	4
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.643	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.643	4
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.643	4
UniProt:Q9ULG1 INO80	1	INO80 [nucleoplasm] (R-HSA-5688910)	0.643	4
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.643	4
UniProt:Q6PI98 INO80C	1	INO80C [nucleoplasm] (R-HSA-5689605)	0.643	4
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.643	4
UniProt:Q9H9F9 ACTR5	1	ACTR5 [nucleoplasm] (R-HSA-5688913)	0.643	4
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q8WV99 ZFN2B			0.527	2
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	2
UniProt:Q5JXX7 TMM31			0.527	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	3
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	2
UniProt:P17706 PTPN2	3	PTPN2 [nucleoplasm] (R-HSA-9008891) PTPN2 [cytosol] (R-HSA-997292) p-PTPN2 [cytosol] (R-HSA-9836510)	0.527	2
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.527	2
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.527	3

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