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UCHL5 [cytosol]
Stable Identifier
R-HSA-1629778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH37
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5K5 UCHL5
Gene Names
UCHL5, UCH37, AD-019, CGI-70
Chain
chain:1-329
Reference Genes
BioGPS Gene:51377 UCHL5
COSMIC (genes):UCHL5 UCHL5
CTD Gene:51377 UCHL5
dbSNP Gene:51377 UCHL5
ENSEMBL:ENSG00000116750 UCHL5
HGNC:19678 UCHL5
KEGG:hsa:51377 UCHL5
Monarch:51377 UCHL5
NCBI Gene:51377 UCHL5
OMIM:610667 UCHL5
UCSC:Q9Y5K5 UCHL5
Reference Transcript
RefSeq:NM_001199262.3 UCHL5
RefSeq:NM_001199261.3 UCHL5
RefSeq:NM_001199263.3 UCHL5
RefSeq:NM_015984.5 UCHL5
Participates
as a component of
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
as an input of
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
as a member of
UCHL5/USP15 [cytosol] (Homo sapiens)
Other forms of this molecule
UCHL5 [nucleoplasm]
Inferred To
uchl5 [cytosol]
(Danio rerio)
uchl5 [cytosol]
(Xenopus tropicalis)
Homologues of UCHL5 [cytosol]
(Sus scrofa)
UCH54 [cytosol]
(Plasmodium falciparum)
Uch-L5 [cytosol]
(Drosophila melanogaster)
uch2 [cytosol]
(Dictyostelium discoideum)
uch2 [cytosol]
(Schizosaccharomyces pombe)
Uchl5 [cytosol]
(Mus musculus)
Uchl5 [cytosol]
(Rattus norvegicus)
UCHL5 [cytosol]
(Bos taurus)
UCHL5 [cytosol]
(Canis familiaris)
UCHL5 [cytosol]
(Gallus gallus)
UCHL5 [cytosol]
(Sus scrofa)
ubh-4 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001186190.1
,
NP_001186192.1
,
NP_001186191.1
,
NP_057068.1
OpenTargets
ENSG00000116750
ENSEMBL
ENST00000367449
,
ENST00000367448
,
ENSP00000356419
,
ENSP00000356424
,
ENSP00000356418
,
ENSG00000116750
,
ENST00000367454
,
ENSP00000356425
,
ENST00000367455
IntEnz
3.4.19.12
GeneCards
UCHL5
HPA
ENSG00000116750-UCHL5
ZINC - Substances
UCHL5_HUMAN
ZINC target
Q9Y5K5
PRO
Q9Y5K5
Pharos - Targets
Q9Y5K5
PDB
4UEL
,
4UF6
,
3TB3
,
3RIS
,
4UEM
,
3A7S
,
4WLP
,
3RII
,
4UF5
,
3IHR
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16186 ADRM1
2
ADRM1 [cytosol]
(R-HSA-5665939)
ADRM1 [nucleoplasm]
(R-HSA-9918361)
0.965
24
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.886
8
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
0.886
8
UniProt:Q6P4R8 NFRKB
1
NFRKB [nucleoplasm]
(R-HSA-5689578)
0.885
15
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.857
8
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
0.837
8
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.837
9
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
0.837
7
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
0.837
7
UniProt:P43686 PSMC4
2
PSMC4 [cytosol]
(R-HSA-68777)
PSMC4 [nucleoplasm]
(R-HSA-174315)
0.837
8
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
0.837
7
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.837
7
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
0.837
7
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.823
11
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.788
7
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
0.788
6
UniProt:Q99460 PSMD1
4
PSMD1 [cytosol]
(R-HSA-68786)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [extracellular region]
(R-HSA-6806194)
0.788
6
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
0.788
7
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.788
6
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
0.788
7
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.773
7
UniProt:P60900 PSMA6
2
PSMA6 [cytosol]
(R-HSA-68734)
PSMA6 [nucleoplasm]
(R-HSA-174314)
0.744
5
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.725
4
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.725
4
UniProt:P28066 PSMA5
5
PSMA5 [cytosol]
(R-HSA-68732)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
0.725
5
UniProt:O00487 PSMD14
5
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
0.725
5
UniProt:P48556 PSMD8
2
PSMD8 [cytosol]
(R-HSA-68808)
PSMD8 [nucleoplasm]
(R-HSA-174318)
0.725
5
UniProt:Q99436 PSMB7
7
PSMB7 [cytosol]
(R-HSA-68759)
PSMB7 [nucleoplasm]
(R-HSA-174331)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
0.725
4
UniProt:Q9H981 ACTR8
1
ACTR8 [nucleoplasm]
(R-HSA-5689565)
0.708
5
UniProt:P28070 PSMB4
4
PSMB4 [cytosol]
(R-HSA-68750)
PSMB4 [nucleoplasm]
(R-HSA-174343)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
0.643
4
UniProt:P28072 PSMB6
4
PSMB6 [cytosol]
(R-HSA-68756)
PSMB6 [nucleoplasm]
(R-HSA-174342)
pro-PSMB6 [cytosol]
(R-HSA-9908130)
PSMB6(1-34) [cytosol]
(R-HSA-9908141)
0.643
4
UniProt:P25787 PSMA2
5
PSMA2 [cytosol]
(R-HSA-68726)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
0.643
4
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.643
4
UniProt:P20618 PSMB1
7
PSMB1 [cytosol]
(R-HSA-68738)
PSMB1 [nucleoplasm]
(R-HSA-174347)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
0.643
4
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.643
3
UniProt:P28074 PSMB5
4
PSMB5 [cytosol]
(R-HSA-68753)
PSMB5 [nucleoplasm]
(R-HSA-174344)
pro-PSMB5 [cytosol]
(R-HSA-9908135)
PSMB5(1-59) [cytosol]
(R-HSA-9908134)
0.643
4
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.643
4
UniProt:P25789 PSMA4
2
PSMA4 [cytosol]
(R-HSA-68730)
PSMA4 [nucleoplasm]
(R-HSA-174324)
0.643
4
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.643
4
UniProt:Q9ULG1 INO80
1
INO80 [nucleoplasm]
(R-HSA-5688910)
0.643
4
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.643
4
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.643
4
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.643
4
UniProt:Q9H9F9 ACTR5
1
ACTR5 [nucleoplasm]
(R-HSA-5688913)
0.643
4
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:Q8WV99 ZFN2B
0.527
2
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.527
2
UniProt:Q5JXX7 TMM31
0.527
3
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.527
3
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.527
2
UniProt:P17706 PTPN2
3
PTPN2 [nucleoplasm]
(R-HSA-9008891)
PTPN2 [cytosol]
(R-HSA-997292)
p-PTPN2 [cytosol]
(R-HSA-9836510)
0.527
2
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.527
2
UniProt:O14818 PSMA7
2
PSMA7 [cytosol]
(R-HSA-68736)
PSMA7 [nucleoplasm]
(R-HSA-174351)
0.527
3
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