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p-S215 FOXO1 [nucleoplasm]
Stable Identifier
R-HSA-5692651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Forkhead box protein O1A, FOXO1_HUMAN, FOXO1A
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)
p-S215 FOXO1 [nucleoplasm] (Homo sapiens)
p-S215 FOXO1 binds RAG gene (Homo sapiens)
p-S215 FOXO1 [nucleoplasm] (Homo sapiens)
p-S215 FOXO1:RAG1,2 gene [nucleoplasm] (Homo sapiens)
p-S215 FOXO1 [nucleoplasm] (Homo sapiens)
p-S215 FOXO1 positively regulates RAG gene expression (Homo sapiens)
p-S215 FOXO1:RAG1,2 gene [nucleoplasm] (Homo sapiens)
p-S215 FOXO1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12778 FOXO1
Gene Names
FOXO1, FKHR, FOXO1A
Chain
chain:1-655
Reference Genes
BioGPS Gene:2308 FOXO1
COSMIC (genes):FOXO1 FOXO1
CTD Gene:2308 FOXO1
dbSNP Gene:2308 FOXO1
ENSEMBL:ENSG00000150907 FOXO1
HGNC:3819 FOXO1
KEGG Gene (Homo sapiens):2308 FOXO1
Monarch:2308 FOXO1
NCBI Gene:2308 FOXO1
OMIM:136533 FOXO1
UCSC:Q12778 FOXO1
Reference Transcript
RefSeq:NM_002015.3 FOXO1
Other Identifiers
0000510288
11727927_a_at
11727928_at
11727929_a_at
11755772_a_at
16778392
202723_s_at
202724_s_at
2308
3510859
3510861
3510904
3510905
3510906
3510907
3510908
3510909
40570_at
7971177
A_23_P151426
A_24_P22079
GE54250
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001223
GO:0001228
GO:0001659
GO:0001678
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006355
GO:0006357
GO:0006464
GO:0006473
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0007165
GO:0008013
GO:0008134
GO:0008150
GO:0008219
GO:0008286
GO:0009056
GO:0009058
GO:0009267
GO:0010508
GO:0019221
GO:0019899
GO:0030154
GO:0031018
GO:0031625
GO:0032868
GO:0032869
GO:0032873
GO:0034599
GO:0034641
GO:0042592
GO:0043065
GO:0043066
GO:0043226
GO:0043565
GO:0045444
GO:0045599
GO:0045732
GO:0045892
GO:0045893
GO:0045944
GO:0048646
GO:0048856
GO:0051721
GO:0070166
GO:0070301
GO:0070417
GO:0070542
GO:0071455
GO:0071549
GO:0071732
GO:0097009
GO:1902617
GO:1903243
HMNXSV003026619
Hs.170133.0.A1_3p_s_at
ILMN_1738816
PH_hs_0010156
TC13001719.hg
U02310_at
U36922_at
g9257221_3p_a_at
Participates
as an output of
p-S182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)
as a component of
p-S215 FOXO1:RAG1,2 gene [nucleoplasm] (Homo sapiens)
as an input of
p-S215 FOXO1 binds RAG gene (Homo sapiens)
Other forms of this molecule
FOXO1 [nucleoplasm]
p-T24,S256,S319-FOXO1 [nucleoplasm]
p-T24,S256,S319-FOXO1 [cytosol]
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
Inferred To
phospho-FOXO1 [nucleoplasm]
(Bos taurus)
phospho-FOXO1 [nucleoplasm]
(Canis familiaris)
phospho-FOXO1 [nucleoplasm]
(Gallus gallus)
phospho-FOXO1 [nucleoplasm]
(Sus scrofa)
phospho-foxo [nucleoplasm]
(Drosophila melanogaster)
phospho-foxo1 [nucleoplasm]
(Xenopus tropicalis)
phospho-foxo1a [nucleoplasm]
(Danio rerio)
phospho-daf-16 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Foxo1 [nucleoplasm]
(Mus musculus)
phospho-Foxo1 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 215
Coordinate
215
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_002006.2
OpenTargets
ENSG00000150907
ZINC - Substances
FOXO1_HUMAN
GeneCards
Q12778
HPA
ENSG00000150907-FOXO1
Ensembl
ENSG00000150907
,
ENST00000379561
,
ENSP00000368880
ZINC target
Q12778
PRO
Q12778
Orphanet
16069
ZINC - Predictions - Purchasable
FOXO1_HUMAN
PDB
6QZS
,
6QZR
,
5DUI
,
4LG0
,
3COA
,
6QVW
,
3CO6
,
3CO7
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.702
4
UniProt:P06493 CDK1
10
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
CDK1 [cytosol]
(R-HSA-170075)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
0.645
5
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.639
8
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.591
5
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.571
2
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.571
2
UniProt:Q92793 CREBBP
3
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
3
UniProt:P14921-3 ETS1
0.544
2
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-427531)
Sirt1 [nucleoplasm]
(R-MMU-5211238)
0.544
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
3
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.508
2
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