Reactome | RAN [nucleoplasm]

RAN [nucleoplasm]

Stable Identifier

R-HSA-165528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RAN GTPase

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External Reference Information

External Reference

UniProt:P62826 RAN

Gene Names

RAN, ARA24, OK/SW-cl.81

Chain

initiator methionine:, chain:2-216

Reference Genes

BioGPS Gene:5901 RAN

COSMIC (genes):RAN RAN

CTD Gene:5901 RAN

dbSNP Gene:5901 RAN

ENSEMBL:ENSG00000132341 RAN

ENSEMBL_homo_sapiens_GENE:ENSG00000132341.12 RAN

HGNC:9846 RAN

KEGG Gene (Homo sapiens):5901 RAN

Monarch:5901 RAN

NCBI Gene:5901 RAN

OMIM:601179 RAN

UCSC:P62826 RAN

Reference Transcript

Other Identifiers

11726279_x_at

11753560_s_at

11758953_s_at

16759202

1839_at

1840_g_at

200749_PM_at

200749_at

200750_PM_s_at

200750_s_at

2901618

2901619

3438028

3438029

3438030

3438031

3438033

3438034

3438040

3438041

3438043

3438044

3438045

3438046

3438047

3438048

38708_at

45716_at

5901

7959882

A_14_P128218

A_23_P128126

GE61422

GE80197

GO:0000054

GO:0000055

GO:0000056

GO:0000070

GO:0000166

GO:0000278

GO:0000287

GO:0000785

GO:0001673

GO:0002177

GO:0003682

GO:0003723

GO:0003824

GO:0003924

GO:0003925

GO:0005049

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005768

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006259

GO:0006606

GO:0006611

GO:0006886

GO:0006913

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007286

GO:0008104

GO:0014070

GO:0015031

GO:0016020

GO:0016032

GO:0016787

GO:0019003

GO:0019904

GO:0021766

GO:0022414

GO:0030036

GO:0030154

GO:0030496

GO:0031047

GO:0031410

GO:0031503

GO:0032092

GO:0032991

GO:0035281

GO:0036126

GO:0042254

GO:0042307

GO:0042470

GO:0042565

GO:0043226

GO:0044877

GO:0045296

GO:0045505

GO:0046039

GO:0046872

GO:0046982

GO:0048856

GO:0051301

GO:0055037

GO:0055086

GO:0061015

GO:0061676

GO:0070062

GO:0070883

GO:0071389

GO:0098772

GO:0140014

GO:0140104

GO:1901135

GO:1902570

HMNXSV003031581

Hs.10842.0.A3_3p_at

ILMN_1757384

PH_hs_0001070

TC12001038.hg

g4092053_3p_a_at

g4092053_3p_x_at

Participates

as a component of

Other forms of this molecule

RAN [cytosol]

Inferred To

Homologues of RAN [nucleoplasm] (Canis familiaris)

RAN [nucleoplasm] (Bos taurus)

RAN [nucleoplasm] (Caenorhabditis elegans)

RAN [nucleoplasm] (Canis familiaris)

RAN [nucleoplasm] (Danio rerio)

RAN [nucleoplasm] (Dictyostelium discoideum)

RAN [nucleoplasm] (Drosophila melanogaster)

RAN [nucleoplasm] (Gallus gallus)

RAN [nucleoplasm] (Mus musculus)

RAN [nucleoplasm] (Rattus norvegicus)

RAN [nucleoplasm] (Saccharomyces cerevisiae)

RAN [nucleoplasm] (Schizosaccharomyces pombe)

RAN [nucleoplasm] (Sus scrofa)

LOC119867725 [nucleoplasm] (Canis familiaris)

ran [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_006316.1, NP_001287725.1, NP_001287726.1

OpenTargets

ENSG00000132341

GeneCards

P62826

HPA

ENSG00000132341-RAN

Ensembl

ENST00000543796, ENST00000392369, ENSG00000132341, ENSP00000376176, ENSP00000446215

PRO

P62826

Pharos - Targets

P62826

HMDB Protein

HMDBP01769

PDB

5DIS, 6LQ9, 3GJX, 5CIT, 8HUF, 4WVF, 7B51, 4HAV, 7DBG, 6A3C, 6X2R, 6CIT, 6X2U, 3GJ3, 5CIW, 1QBK, 1IBR, 2MMC, 4GMX, 5DLQ, 6X2W, 6XJT, 8UX1, 4OL0, 3GJ8, 7CND, 1K5G, 5YTB, 7MNW, 3NC0, 5JLJ, 6XJU, 3EA5, 6A38, 5UWR, 5CLQ, 4HB0, 7MNY, 4C0Q, 5UWT, 6Q84, 7MNZ, 7L5E, 6XJP, 6A3B, 8ITV, 7MO1, 6TVO, 5UWH, 7MNT, 8HQ4, 7MNV, 7MO4, 3CH5, 6M6X, 4HB4, 5YRO, 3NC1, 6X2Y, 5CLL, 5DIF, 6X2M, 3NBY, 5UWQ, 6M60, 7MNR, 3GJ6, 8HQ6, 6Q82, 5CIQ, 5DHF, 6X2P, 3GJ4, 5ZPU, 7MO2, 5UWW, 4HAT, 2MMG, 6A3E, 3ZJY, 1I2M, 5DI9, 5UWJ, 6XJS, 5YSU, 7MO5, 5UWP, 3NBZ, 8HQ5, 4HB2, 4HAY, 3GJ7, 7MNX, 2N1B, 1K5D, 5DHA, 5UWS, 4HAW, 6A3A, 8HUG, 3GJ5, 5UWU, 8HQ3, 6KFT, 4GPT, 7MO3, 6X2S, 4HAU, 5CJ2, 6XJR, 7MNU, 1RRP, 3GJ0, 5UWI, 5YST, 7MNP, 6X2V, 6X2X, 5UWO, 4HB3, 5DH9, 7MNQ, 4HAZ, 7YPZ, 7MO0, 7MNS, 6X2O, 5FYQ, 4HAX

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.946	19
UniProt:P49792 RANBP2	6	polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [cytosol] (R-HSA-157703)	0.861	7
GDP [ChEBI:17552]	7	GDP [lysosomal membrane] (R-ALL-9628545) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.806	7
UniProt:P43487 RANBP1	1	RANBP1 [nuclear envelope] (R-HSA-167651)	0.77	6
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.761	9
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.725	5
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.725	6
UniProt:Q6P5F9 Xpo1	2	Xpo1 [nucleoplasm] (R-MMU-9769779) Xpo1 [cytosol] (R-MMU-165539)	0.676	3
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.65	9
UniProt:Q9HD47 RANGRF	1	RANGRF [cytosol] (R-HSA-5216063)	0.643	4
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.643	4
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.635	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P47813 EIF1AX	1	EIF1AX [cytosol] (R-HSA-72557)	0.591	3
UniProt:Q92973 TNPO1	2	TNPO1 [cilium] (R-HSA-5624896) TNPO1 [cytosol] (R-HSA-180743)	0.59	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.564	2
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P06276 BCHE	2	BCHE [extracellular region] (R-HSA-434469) BCHE [plasma membrane] (R-HSA-3640835)	0.556	3
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.556	3
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:P35658 NUP214	2	NUP214 [nucleoplasm] (R-HSA-451222) NUP214 [cytosol] (R-HSA-157691)	0.527	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.491	5
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.463	2

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