Reactome | p-Y753,Y759-PLCG2 [cytosol]

p-Y753,Y759-PLCG2 [cytosol]

Stable Identifier

R-HSA-5607631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PLCG2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2, PLCG2_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15509800	Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2 Kim, YJ, Sekiya, F, Poulin, B, Bae, YS, Rhee, SG	Mol Cell Biol	2004

External Reference Information

External Reference

UniProt:P16885 PLCG2

Gene Names

PLCG2

Chain

chain:1-1265

Reference Genes

BioGPS Gene:5336 PLCG2

COSMIC (genes):PLCG2 PLCG2

CTD Gene:5336 PLCG2

dbSNP Gene:5336 PLCG2

ENSEMBL:ENSG00000197943 PLCG2

HGNC:9066 PLCG2

KEGG Gene (Homo sapiens):5336 PLCG2

Monarch:5336 PLCG2

NCBI Gene:5336 PLCG2

OMIM:600220 PLCG2

UCSC:P16885 PLCG2

Reference Transcript

RefSeq:NM_002661.4 PLCG2

Other Identifiers

0000360131

00562+3.1.4.11

04070+3.1.4.11

1085_s_at

11720244_at

1557993_at

16821330

16821365

20099

20100

204613_at

230917_at

2K2J

2W2W

2W2X

3670950

3670955

3670956

3670973

3670976

3670978

3670985

3670986

3670990

3670991

3670993

3670994

3670996

3670997

3670999

3671000

3671004

3671006

3671007

3671008

3671009

3671011

3671012

3671014

3671016

3671017

3671021

3671026

3671029

3671030

3671034

3671037

3671038

3671039

3671042

3671048

3671049

3671050

3671051

3671052

3671053

3671054

3671055

3671056

3671057

37180_at

4280

5336

7997453

7997489

A0A0A0MRF9

A_23_P106675

A_32_P52632

AAA60112

AAH07565

AAH11772

AAH14561

AAH18646

AAQ76815

AB208914

AC092142

AC098966

AC099524

AY364256

BAD92151

BC007565

BC011772

BC014561

BC018646

CAA32194

CAB004280

CCDS42204

CH471114

EAW95524

EAW95525

ENSG00000197943

ENSP00000482457

ENST00000564138

ENST00000564138.5

EntrezGene:5336

EntrezGene:PLCG2

g4505870_3p_at

GE57955

GE61863

GO:0001784

GO:0002092

GO:0002223

GO:0002316

GO:0002376

GO:0003674

GO:0004435

GO:0004629

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0006661

GO:0006810

GO:0006950

GO:0007165

GO:0007267

GO:0008081

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0009395

GO:0010468

GO:0010634

GO:0016042

GO:0016055

GO:0016192

GO:0016787

GO:0019722

GO:0030154

GO:0030168

GO:0030183

GO:0032237

GO:0032481

GO:0032496

GO:0032959

GO:0035556

GO:0038095

GO:0038096

GO:0040011

GO:0042592

GO:0043069

GO:0043226

GO:0043647

GO:0044281

GO:0048015

GO:0048856

GO:0048870

GO:0050852

GO:0050853

GO:0051209

GO:0055085

GO:0070062

H3BQV5

HGNC:9066

HPA020099

HPA020100

Hs.6179.2.A1_3p_at

Hs.6179.2.A1_3p_x_at

Hs2.382891.1.S1_3p_at

Hs2.382891.1.S1_3p_x_at

ILMN_1815719

IPR000008

IPR000909

IPR000980

IPR001192

IPR001452

IPR001711

IPR001849

IPR011992

IPR011993

IPR016279

IPR017946

IPR028381

IPR035023

IPR035024

IPR035723

IPR035892

IPR036028

IPR036860

LRG_376

M37238

M37238_s_at

MIM:600220

MIM:614468

MIM:614878

NM_002661

NP_002652

PF00017

PF00018

PF00168

PF00387

PF00388

PH_hs_0026742

PLCG2

PLCG2-207

PR00390

PR00401

PR00452

SM00148

SM00149

SM00233

SM00239

SM00252

SM00326

TC16000643.hg

TC16000644.hg

TC16001663.hg

UPI00001411F7

X14034

Participant Of

hasComponent

pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane]

output

1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG

input

p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane

Other forms of this molecule

p-Y753,Y759,Y1217-PLCG2 [plasma membrane]

p-PLCG2 [plasma membrane]

PLCG2 [plasma membrane]

PLCG2 [cytosol]

PLCG2 [plasma membrane]

p-4Y-PLCG2 [plasma membrane]

p-Y753,Y759-PLCG2 [plasma membrane]

PLCG2 [cytosol]

p-Y-PLCG2 [cytosol]

Inferred To

phospho-p-Y753,Y759-PLCG2 [cytosol] (Bos taurus)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Caenorhabditis elegans)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Canis familiaris)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Danio rerio)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Dictyostelium discoideum)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Drosophila melanogaster)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Gallus gallus)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Mus musculus)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Plasmodium falciparum)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Rattus norvegicus)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Saccharomyces cerevisiae)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Schizosaccharomyces pombe)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Sus scrofa)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 753

Coordinate

753

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 759

Coordinate

759

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002652.2

OpenTargets

ENSG00000197943

GeneCards

P16885

ZINC - Substances

PLCG2_HUMAN

ZINC target

P16885

PRO

P16885

ZINC - Predictions - Purchasable

PLCG2_HUMAN

Orphanet

21179

HMDB Protein

HMDBP00230

PDB

2W2W, 2W2X, 2K2J

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.744	5
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.609	3
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.589	2
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.525	2
UniProt:O95073-2 FSBP			0.508	2
UniProt:O43242 PSMD3	5	PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.508	2
UniProt:Q99645 EPYC			0.488	2
UniProt:Q68G74 LHX8			0.488	2
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963)	0.488	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.488	2
UniProt:O95997 PTTG1	2	PTTG1 [cytosol] (R-HSA-174190) K11polyUb-PTTG1 [cytosol] (R-HSA-3095943)	0.488	2
UniProt:P19419 ELK1	2	p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350) ELK1 [nucleoplasm] (R-HSA-3009346)	0.488	2