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What is Reactome ?
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MCM2 [nucleoplasm]
Stable Identifier
R-HSA-68557
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mcm2, DNA replication licensing factor MCM2, Nuclear protein BM28
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDT1 binds MCM2-7 (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Formation of MCM2-7 complex (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence (Homo sapiens)
MITF-M-dependent MCM2 gene expression (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49736 MCM2
Gene Names
MCM2, BM28, CCNL1, CDCL1, KIAA0030
Chain
initiator methionine:, chain:2-904
Reference Genes
BioGPS Gene:4171 MCM2
COSMIC (genes):CCNL1 MCM2
COSMIC (genes):MCM2 MCM2
CTD Gene:4171 MCM2
dbSNP Gene:4171 MCM2
ENSEMBL:ENSG00000073111 MCM2
HGNC:6944 MCM2
KEGG:hsa:4171 MCM2
Monarch:4171 MCM2
NCBI Gene:4171 MCM2
OMIM:116945 MCM2
UCSC:P49736 MCM2
Reference Transcript
RefSeq:NM_004526.3 MCM2
Other Identifiers
11715991_a_at
11715992_s_at
11746594_a_at
11756666_x_at
16945101
202107_PM_s_at
202107_s_at
2640859
2640861
2640862
2640863
2640864
2640865
2640866
2640867
2640868
2640869
2640870
2640871
2640873
2640874
2640875
2640876
2640877
2640878
2640879
2640881
2640882
2640883
2640884
2640885
35312_at
4171
8082350
A_14_P136042
A_32_P103633
D21063_at
GE57107
GO:0000727
GO:0000781
GO:0000785
GO:0003677
GO:0003688
GO:0003697
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005664
GO:0005694
GO:0005737
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006281
GO:0006310
GO:0006325
GO:0006334
GO:0006915
GO:0012501
GO:0016787
GO:0016887
GO:0017116
GO:0019899
GO:0030174
GO:0032508
GO:0042393
GO:0042555
GO:0043138
GO:0043226
GO:0046872
GO:0048856
GO:0065003
GO:0071162
GO:0071353
GO:0090102
GO:0140097
GO:0140657
GO:1902975
GO:1905775
HMNXSV003042467
ILMN_1681503
PH_hs_0003681
TC03000664.hg
g4758705_3p_s_at
Participates
as an output of
MITF-M-dependent MCM2 gene expression (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
as an input of
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
as a component of
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Inferred To
mcm-2 [nucleoplasm]
(Caenorhabditis elegans)
Mcm2 [nucleoplasm]
(Rattus norvegicus)
mcm2 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of MCM2 [nucleoplasm]
(Danio rerio)
MCM2 [nucleoplasm]
(Bos taurus)
MCM2 [nucleoplasm]
(Canis familiaris)
MCM2 [nucleoplasm]
(Drosophila melanogaster)
MCM2 [nucleoplasm]
(Gallus gallus)
MCM2 [nucleoplasm]
(Mus musculus)
MCM2 [nucleoplasm]
(Plasmodium falciparum)
MCM2 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM2 [nucleoplasm]
(Schizosaccharomyces pombe)
MCM2 [nucleoplasm]
(Sus scrofa)
MCM2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004517.2
OpenTargets
ENSG00000073111
ENSEMBL
ENSP00000265056
,
ENST00000265056
IntEnz
3.6.4.12
HPA
ENSG00000073111-MCM2
PRO
P49736
Pharos - Targets
P49736
GlyGen
P49736
Orphanet
MCM2
HMDB Protein
HMDBP11816
PDB
8YJM
,
8YJF
,
7CIZ
,
5BNX
,
7PLO
,
8B9D
,
6YA7
,
5BNV
,
6XTX
,
5BO0
,
6XTY
,
7CJ0
,
4UUZ
,
5C3I
,
7W1Y
,
5JA4
,
7W68
,
7PFO
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.951
19
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.931
24
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.924
9
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.89
12
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.83
9
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.802
6
UniProt:P33992 MCM5
1
MCM5 [nucleoplasm]
(R-HSA-68551)
0.8
5
UniProt:Q9BTE3 MCMBP
0.784
5
UniProt:Q9NVP2 ASF1B
0.773
6
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.748
9
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.708
8
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.657
3
UniProt:P84243 H3-3A
18
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
H3F3A [extracellular region]
(R-HSA-977567)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
Me1K5-H3-3A [nucleoplasm]
(R-HSA-9864864)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
0.656
3
UniProt:Q96H20 SNF8
1
SNF8 [cytosol]
(R-HSA-917711)
0.633
8
UniProt:Q9NYP3 DONS
0.629
10
UniProt:Q9Y468 L3MBTL1
1
L3MBTL1 [nucleoplasm]
(R-HSA-3222110)
0.623
3
UniProt:O43823 AKAP8
0.581
7
UniProt:Q71DI3 H3C15
20
2xAcK-HIST2H3A [nucleoplasm]
(R-HSA-427525)
Me1K5-HIST2H3A [nucleoplasm]
(R-HSA-9677679)
Me2aR27-HIST2H3A [nucleoplasm]
(R-HSA-5229057)
Me2aR18-HIST2H3A [nucleoplasm]
(R-HSA-5229063)
Me2sR9-HIST2H3A [nucleoplasm]
(R-HSA-5211327)
Me2sR3-HIST2H3A [nucleoplasm]
(R-HSA-5218930)
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8870892)
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871273)
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871304)
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871292)
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8865607)
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871296)
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871290)
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871302)
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871289)
Me2K28-HIST2H3A [nucleoplasm]
(R-HSA-4754197)
MeK37-HIST2H3A [nucleoplasm]
(R-HSA-4722131)
MeK80-HIST2H3A [nucleoplasm]
(R-HSA-5649805)
Me3K80-HIST2H3A [nucleoplasm]
(R-HSA-5649798)
Me2K80-HIST2H3A [nucleoplasm]
(R-HSA-5649803)
0.576
5
UniProt:P49450 CENPA
2
CENPA [nucleoplasm]
(R-HSA-606322)
CENPA [cytosol]
(R-HSA-375317)
0.576
3
UniProt:Q9BRX5 GINS3
1
GINS3 [nucleoplasm]
(R-HSA-5688046)
0.574
2
UniProt:O75419 CDC45
1
CDC45 [nucleoplasm]
(R-HSA-68563)
0.574
2
UniProt:Q8IYD8 FANCM
3
FANCM [cytosol]
(R-HSA-420802)
p-S1045-FANCM [nucleoplasm]
(R-HSA-6788401)
FANCM [nucleoplasm]
(R-HSA-419535)
0.539
5
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
4
UniProt:Q96HA7 TONSL
0.527
5
UniProt:Q9P0M6 H2AW
0.527
2
UniProt:Q9BPZ2 SPI2B
0.527
2
UniProt:Q86UY6 NAA40
0.527
2
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
4
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
UniProt:P03433 PA
4
PA [extracellular region]
(R-FLU-169243)
PA [endosome lumen]
(R-FLU-189131)
PA [cytosol]
(R-FLU-195948)
PA [nucleoplasm]
(R-FLU-188877)
0.462
2
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