Reactome | K48polyUb-PRKDC [cytosol]

K48polyUb-PRKDC [cytosol]

Stable Identifier

R-HSA-8938766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DNA-dependent protein kinase catalytic subunit, PRKDC_HUMAN

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External Reference Information

External Reference

UniProt:P78527 PRKDC

Gene Names

PRKDC, HYRC, HYRC1

Chain

chain:1-4128

Reference Genes

BioGPS Gene:5591 PRKDC

CTD Gene:5591 PRKDC

dbSNP Gene:5591 PRKDC

ENSEMBL:ENSG00000253729 PRKDC

HGNC:9413 PRKDC

KEGG Gene (Homo sapiens):5591 PRKDC

Monarch:5591 PRKDC

NCBI Gene:5591 PRKDC

OMIM:600899 PRKDC

UCSC:P78527 PRKDC

Reference Transcript

Other Identifiers

0006550403

11719391_a_at

11740423_a_at

11749467_a_at

11757399_s_at

1250_at

17076867

2012_s_at

208694_at

210543_s_at

3134045

3134046

3134047

3134048

3134049

3134050

3134052

3134053

3134058

3134059

3134060

3134061

3134064

3134067

3134068

3134070

3134071

3134072

3134074

3134075

3134077

3134078

3134079

3134081

3134082

3134083

3134084

3134085

3134086

3134087

3134088

3134089

3134090

3134092

3134094

3134095

3134098

3134100

3134101

3134102

3134103

3134104

3134105

3134107

3134108

3134111

3134112

3134113

3134115

3134116

3134117

3134118

3134119

3134120

3134121

3134122

3134124

3134125

3134126

3134127

3134129

3134130

3134132

3134133

3134137

3134138

3134139

3134140

3134141

3134142

3134145

3134146

3134147

3134148

3134151

3134154

3134155

3134156

3134159

3134160

3134161

3134165

3134169

3134171

3134172

3134173

3134174

3134176

3134177

3134179

3134180

3134181

3134182

3134184

3134186

3134187

3134188

3134189

3134190

3134191

3134192

3134193

3134194

3134195

3134197

3134198

40129_at

5591

8150599

A_23_P9603

A_32_P25204

A_33_P3337599

GE62614

GE81694

GO:0000003

GO:0000166

GO:0000228

GO:0000278

GO:0000723

GO:0000784

GO:0001756

GO:0001933

GO:0002218

GO:0002326

GO:0002328

GO:0002360

GO:0002376

GO:0002377

GO:0002638

GO:0002684

GO:0003674

GO:0003677

GO:0003690

GO:0003723

GO:0004672

GO:0004674

GO:0004677

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005958

GO:0006259

GO:0006281

GO:0006302

GO:0006303

GO:0006310

GO:0006464

GO:0006468

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0007420

GO:0007507

GO:0007568

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008630

GO:0009058

GO:0009790

GO:0010212

GO:0010332

GO:0014823

GO:0016020

GO:0016233

GO:0016301

GO:0016310

GO:0016567

GO:0016740

GO:0018105

GO:0019899

GO:0019904

GO:0030098

GO:0030154

GO:0031648

GO:0032481

GO:0032869

GO:0032991

GO:0032993

GO:0033077

GO:0033151

GO:0033152

GO:0033153

GO:0034641

GO:0035234

GO:0040007

GO:0042592

GO:0042752

GO:0043065

GO:0043066

GO:0043167

GO:0043226

GO:0045087

GO:0045944

GO:0048146

GO:0048511

GO:0048536

GO:0048538

GO:0048639

GO:0048646

GO:0048660

GO:0048856

GO:0050678

GO:0051276

GO:0070419

GO:0072431

GO:0097681

GO:2000773

GO:2001034

GO:2001229

ILMN_1769517

ILMN_1797499

ILMN_2253648

ILMN_2334121

PH_hs_0025022

TC08001191.hg

U35835_s_at

U47077_at

g13570016_3p_at

g13570016_3p_x_at

g13606055_3p_a_at

Participant Of

output

RNF144A polyubiquitinates PRKDC

Other forms of this molecule

p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]

PRKDC [nucleoplasm]

PRKDC [cytosol]

Inferred To

PRKDC [cytosol] (Bos taurus)

PRKDC [cytosol] (Canis familiaris)

PRKDC [cytosol] (Gallus gallus)

PRKDC [cytosol] (Sus scrofa)

prkdc [cytosol] (Danio rerio)

prkdc [cytosol] (Xenopus tropicalis)

Prkdc [cytosol] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001075109.1, NP_008835.5

ZINC - World Drugs

PRKDC_HUMAN

OpenTargets

ENSG00000253729

ZINC - FDA approved

PRKDC_HUMAN

ZINC - Substances

PRKDC_HUMAN

ZINC - Biogenic

PRKDC_HUMAN

ZINC target

P78527

PRO

P78527

PDB

5LUQ, 5W1R, 5Y3R

ZINC - Investigational

PRKDC_HUMAN

HPA

ENSG00000253729-PRKDC

GeneCards

P78527

Ensembl

ENSG00000253729, ENST00000338368, ENST00000314191, ENSP00000345182, ENSP00000313420

ZINC - Predictions - Purchasable

PRKDC_HUMAN

Orphanet

21609

HMDB Protein

HMDBP01324

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [nucleoplasm] (R-HSA-58274)	0.875	8
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813)	0.87	7
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.623	5
UniProt:Q96SD1 DCLRE1C	3	p-S645-DCLRE1C [nucleoplasm] (R-HSA-5686708) p-S516,S645-DCLRE1C [nucleoplasm] (R-HSA-5687176) DCLRE1C [nucleoplasm] (R-HSA-5686712)	0.612	4
UniProt:Q9Y4R8 TELO2			0.597	5
UniProt:Q96RI1-2 NR1H4	2	NR1H4-2 [nucleoplasm] (R-HSA-3196161) SUMO1-K132,K289-NR1H4 [nucleoplasm] (R-HSA-4755487)	0.558	4
IntAct:EBI-2602074 TMPS2			0.527	4
IntAct:EBI-3954042 PLA1A			0.527	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O00743 PPP6C	2	PPP6C [cytosol] (R-HSA-5685719) PPP6C [nucleoplasm] (R-HSA-9686576)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:P68431 H3C1	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.527	2
IntAct:EBI-1776214 KLK3			0.527	4
UniProt:P09874 PARP1	4	SUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) SUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.527	5
UniProt:P14921 ETS1	2	p-T38-ETS1 [nucleoplasm] (R-HSA-3132720) ETS1 [nucleoplasm] (R-HSA-1629809)	0.525	2
UniProt:P17947 SPI1	1	SPI1 [nucleoplasm] (R-HSA-8865503)	0.525	2
UniProt:P50549 ETV1			0.525	2
UniProt:P17936 IGFBP3	15	IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) IGFBP3 [extracellular region] (R-HSA-381512) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454)	0.499	2
UniProt:O43918 AIRE			0.499	2
UniProt:P09629 HXB7			0.499	2
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.499	3
UniProt:Q9BPZ7 MAPKAP1	1	MAPKAP1 [cytosol] (R-HSA-3006620)	0.499	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.499	2
UniProt:P10276 RARA	3	SUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.499	3
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	2
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.462	2
UniProt:P56180-2 TPTE			0.462	2
UniProt:P11308 ERG			0.462	7
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.462	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2
UniProt:P11387 TOP1	2	SUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	2

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