Reactome | K48polyUb-PRKDC [cytosol]

K48polyUb-PRKDC [cytosol]

Stable Identifier

R-HSA-8938766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DNA-dependent protein kinase catalytic subunit, PRKDC_HUMAN

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External Reference Information

External Reference

UniProt:P78527 PRKDC

Gene Names

PRKDC, HYRC, HYRC1

Chain

chain:1-4128

Reference Genes

BioGPS Gene:5591 PRKDC

COSMIC (genes):PRKDC PRKDC

CTD Gene:5591 PRKDC

dbSNP Gene:5591 PRKDC

ENSEMBL:ENSG00000253729.8 PRKDC

HGNC:9413 PRKDC

KEGG Gene (Homo sapiens):5591 PRKDC

Monarch:5591 PRKDC

NCBI Gene:5591 PRKDC

OMIM:600899 PRKDC

UCSC:P78527 PRKDC

Reference Transcript

Other Identifiers

0006550403

11719391_a_at

11740423_a_at

11749467_a_at

11757399_s_at

1250_at

17076867

2012_s_at

208694_PM_at

208694_at

210543_PM_s_at

210543_s_at

3134045

3134046

3134047

3134048

3134049

3134050

3134052

3134053

3134058

3134059

3134060

3134061

3134064

3134067

3134068

3134070

3134071

3134072

3134074

3134075

3134077

3134078

3134079

3134081

3134082

3134083

3134084

3134085

3134086

3134087

3134088

3134089

3134090

3134092

3134094

3134095

3134098

3134100

3134101

3134102

3134103

3134104

3134105

3134107

3134108

3134111

3134112

3134113

3134115

3134116

3134117

3134118

3134119

3134120

3134121

3134122

3134124

3134125

3134126

3134127

3134129

3134130

3134132

3134133

3134137

3134138

3134139

3134140

3134141

3134142

3134145

3134146

3134147

3134148

3134151

3134154

3134155

3134156

3134159

3134160

3134161

3134165

3134169

3134171

3134172

3134173

3134174

3134176

3134177

3134179

3134180

3134181

3134182

3134184

3134186

3134187

3134188

3134189

3134190

3134191

3134192

3134193

3134194

3134195

3134197

3134198

40129_at

5591

8150599

A_23_P9603

A_32_P25204

A_33_P3337599

GE62614

GE81694

GO:0000166

GO:0000278

GO:0000460

GO:0000723

GO:0000781

GO:0001756

GO:0001933

GO:0002218

GO:0002326

GO:0002327

GO:0002328

GO:0002360

GO:0002376

GO:0003677

GO:0003690

GO:0003723

GO:0004672

GO:0004674

GO:0004677

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005958

GO:0006281

GO:0006302

GO:0006303

GO:0006310

GO:0006351

GO:0006355

GO:0006468

GO:0006974

GO:0007420

GO:0007507

GO:0008630

GO:0010212

GO:0010332

GO:0012501

GO:0016020

GO:0016233

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019219

GO:0019899

GO:0019904

GO:0022414

GO:0023052

GO:0030098

GO:0030154

GO:0031571

GO:0031648

GO:0032040

GO:0032200

GO:0032869

GO:0032991

GO:0032993

GO:0033077

GO:0033151

GO:0033152

GO:0033153

GO:0034462

GO:0034511

GO:0035234

GO:0036211

GO:0042254

GO:0042752

GO:0043065

GO:0043066

GO:0043226

GO:0045087

GO:0045621

GO:0045648

GO:0045727

GO:0045944

GO:0048511

GO:0048584

GO:0048660

GO:0048856

GO:0050678

GO:0060255

GO:0061629

GO:0065003

GO:0070418

GO:0070419

GO:0080135

GO:0097681

GO:0098542

GO:0106310

GO:0140096

GO:1902036

GO:1905221

GO:2001034

HMNXSV003015027

ILMN_1769517

ILMN_2253648

ILMN_2334121

PH_hs_0025022

RNA146935|p0039_imsncRNA85

TC08001191.hg

U35835_s_at

U47077_at

g13570016_3p_at

g13570016_3p_x_at

g13606055_3p_a_at

Participates

as an output of

RNF144A polyubiquitinates PRKDC (Homo sapiens)

Other forms of this molecule

PRKDC [cytosol]

PRKDC [nucleoplasm]

p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]

Inferred To

PRKDC [cytosol] (Bos taurus)

PRKDC [cytosol] (Gallus gallus)

PRKDC [cytosol] (Sus scrofa)

prkdc [cytosol] (Xenopus tropicalis)

K48polyUb-PRKDC [cytosol] (Canis familiaris)

K48polyUb-PRKDC [cytosol] (Danio rerio)

dnapkcs [cytosol] (Dictyostelium discoideum)

Prkdc [cytosol] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001075109.1, NP_008835.5

ZINC - World Drugs

PRKDC_HUMAN

Guide to Pharmacology - Targets

2800

OpenTargets

ENSG00000253729

ZINC - FDA approved

PRKDC_HUMAN

ZINC - Substances

PRKDC_HUMAN

ZINC - Biogenic

PRKDC_HUMAN

ZINC target

P78527

PRO

P78527

PDB

7NFC, 7K11, 6ZHE, 7K10, 7K0Y, 6ZH4, 7SGL, 7OTP, 7NFE, 7OTM, 7SUD, 6ZH2, 7K19, 6ZH8, 6ZFP, 7OTV, 7K1J, 7OTW, 6ZH6, 7LT3, 7K1B, 7SU3, 7K1N, 5Y3R, 5LUQ, 7OTY, 7K1K, 5W1R, 6ZHA

ZINC - Investigational

PRKDC_HUMAN

HPA

ENSG00000253729-PRKDC

GeneCards

P78527

Ensembl

ENSG00000253729, ENST00000338368, ENSP00000313420, ENSP00000345182, ENST00000314191

Pharos - Targets

P78527

ZINC - Predictions - Purchasable

PRKDC_HUMAN

Orphanet

21609

HMDB Protein

HMDBP01324

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13010 XRCC5	4	XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [nucleoplasm] (R-HSA-58274)	0.867	8
UniProt:P12956 XRCC6	5	XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [nucleoplasm] (R-HSA-58272)	0.86	7
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.623	5
UniProt:Q96SD1 DCLRE1C	3	p-S516,S645-DCLRE1C [nucleoplasm] (R-HSA-5687176) p-S645-DCLRE1C [nucleoplasm] (R-HSA-5686708) DCLRE1C [nucleoplasm] (R-HSA-5686712)	0.612	4
UniProt:Q9Y4R8 TELO2			0.597	5
UniProt:Q96RI1-2 NR1H4	2	SUMO1-K132,K289-NR1H4 [nucleoplasm] (R-HSA-4755487) NR1H4-2 [nucleoplasm] (R-HSA-3196161)	0.558	4
IntAct:EBI-2602074 TMPS2			0.527	4
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.527	5
IntAct:EBI-3954042 PLA1A			0.527	4
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O00743 PPP6C	2	PPP6C [cytosol] (R-HSA-5685719) PPP6C [nucleoplasm] (R-HSA-9686576)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
IntAct:EBI-1776214 KLK3			0.527	4
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.525	2
UniProt:P50549 ETV1			0.525	2
UniProt:P17947 SPI1	1	SPI1 [nucleoplasm] (R-HSA-8865503)	0.525	2
UniProt:O43918 AIRE			0.499	2
UniProt:P09629 HXB7			0.499	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.499	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.499	3
UniProt:Q9BPZ7 MAPKAP1	1	MAPKAP1 [cytosol] (R-HSA-3006620)	0.499	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.499	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.483	2
UniProt:P21709 EPHA1	2	EPHA1 [plasma membrane] (R-HSA-211415) p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336)	0.483	2
UniProt:P68431 H3C1	20	HIST1H3A [extracellular region] (R-HSA-977570) 2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288)	0.483	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.462	2
UniProt:P11308 ERG			0.462	7
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.462	3
UniProt:P05919 vpu	6	VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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