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What is Reactome ?
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MYD88 [endosome membrane]
Stable Identifier
R-HSA-975123
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
MyD88
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
MYD88 homodimer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
MYD88 homodimer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
MYD88 homodimer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
MYD88 homodimer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
MYD88 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99836 MYD88
Gene Names
MYD88
Chain
chain:1-296
Reference Genes
COSMIC (genes):MYD88 MYD88
dbSNP Gene:4615 MYD88
ENSEMBL:ENSG00000172936 MYD88
Participates
as a component of
MYD88 homodimer [endosome membrane] (Homo sapiens)
MyD88 oligomer [endosome membrane] (Homo sapiens)
Other forms of this molecule
MyD88 R196C [cytosol]
MyD88 E52del [cytosol]
MyD88 L93P [cytosol]
MyD88 S34Y [cytosol]
MyD88 E65del [cytosol]
MYD88 [plasma membrane]
MYD88 [cytosol]
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.958
40
UniProt:Q9NWZ3 IRAK4
9
IRAK4 [cytosol]
(R-HSA-166081)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
0.922
15
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.861
9
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.837
8
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.758
4
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-167992)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-9637646)
0.737
4
UniProt:P51617 IRAK1
14
IRAK1 [cytosol]
(R-HSA-446639)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
0.723
4
UniProt:O14836 TNFRSF13B
1
TAC1 [plasma membrane]
(R-HSA-5668752)
0.692
12
UniProt:Q6SZW1 SARM1
0.622
5
UniProt:P10599 TXN
4
TXN [cytosol]
(R-HSA-66000)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
0.602
4
UniProt:Q8NF50 DOCK8
1
DOCK8 [cytosol]
(R-HSA-1011619)
0.576
3
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.573
3
UniProt:P13682 ZNF35
0.556
3
UniProt:Q69FE3 Q69FE3
0.556
5
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q6IQ16 SPOPL
1
SPOPL [nucleoplasm]
(R-HSA-5635036)
0.556
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.543
3
UniProt:Q93009 USP7
2
USP7 [nucleoplasm]
(R-HSA-3215278)
USP7 [cytosol]
(R-HSA-8853511)
0.543
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.543
3
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.524
3
UniProt:Q9UBN7 HDAC6
4
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [nucleoplasm]
(R-HSA-351589)
0.524
6
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.462
8
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![MYD88 [endosome membrane] icon](/icon/R-ICO-013037.svg){kind=icon}
