Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
polyUb-K377,K604,K634-RIPK1 [cytosol]
Stable Identifier
R-HSA-9818391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
polyUb-K377,K604,K634-RIP1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
polyUb-K377,K604,K634-RIPK1 [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
polyUb-K377,K604,K634-RIPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13546 RIPK1
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Reference Genes
BioGPS Gene:8737 RIPK1
COSMIC (genes):RIPK1 RIPK1
CTD Gene:8737 RIPK1
dbSNP Gene:8737 RIPK1
ENSEMBL:ENSG00000137275 RIPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000137275.16 RIPK1
HGNC:10019 RIPK1
KEGG Gene (Homo sapiens):8737 RIPK1
Monarch:8737 RIPK1
NCBI Gene:8737 RIPK1
OMIM:603453 RIPK1
UCSC:Q13546 RIPK1
Reference Transcript
RefSeq:NM_003804.4 RIPK1
RefSeq:XM_005249457.3 RIPK1
Other Identifiers
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
17004295
209941_PM_at
209941_at
226551_PM_at
226551_at
2892343
2892344
2892345
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892363
2892364
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892383
2892385
2892386
2892387
2892388
2892389
2939062
2939063
40696_at
475_at
51161_at
8116622
8737
A_23_P370005
A_33_P3279059
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006950
GO:0006954
GO:0006979
GO:0007165
GO:0008152
GO:0010008
GO:0010628
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031264
GO:0031349
GO:0031410
GO:0031625
GO:0032103
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034612
GO:0035556
GO:0035591
GO:0036211
GO:0036289
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043226
GO:0043235
GO:0043410
GO:0043525
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060090
GO:0060545
GO:0060546
GO:0062100
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071345
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0106310
GO:0140096
GO:1900119
GO:1901026
GO:1901224
GO:1903265
GO:1903800
GO:1990000
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
HMNXSV003025407
HMNXSV003028067
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_2119535
PH_hs_0018906
TC06000023.hg
TC06002463.hg
U50062_at
g3426026_3p_at
Participates
as a component of
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
K48polyUb-RIPK1 [cytosol]
PolyUb-RIPK1 [cytosol]
RIPK1 D324N [cytosol]
RIPK1 D324Y [cytosol]
RIPK1 D324V [cytosol]
RIPK1 D324H [cytosol]
RIPK1 [plasma membrane]
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
K63,M1polyUb-RIPK1 [cytosol]
RIPK1(1-324) [cytosol]
RIPK1(325-671) [cytosol]
K63,M1polyUb, p-T189-RIPK1 [cytosol]
p-S320-RIPK1 [cytosol]
p-S357-RIPK1 [cytosol]
p-S166-RIPK1 [cytosol]
K63polyUb-RIPK1 [cytosol]
RIPK1 [endosome membrane]
RIPK1 [cytosol]
Inferred To
Ghost homologue of polyUb-K377,K604,K634-RIPK1 [cytosol]
(Danio rerio)
Homologues of polyUb-K377,K604,K634-RIPK1 [cytosol]
(Xenopus tropicalis)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(Gallus gallus)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(Mus musculus)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(Xenopus tropicalis)
Ripk1 [cytosol]
(Rattus norvegicus)
RIPK1 [cytosol]
(Bos taurus)
RIPK1 [cytosol]
(Canis familiaris)
RIPK1 [cytosol]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 377
Coordinate
377
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 604
Coordinate
604
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 634
Coordinate
634
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005249514.2
,
NP_003795.2
ZINC - World Drugs
RIPK1_HUMAN
Guide to Pharmacology - Targets
2189
OpenTargets
ENSG00000137275
ZINC - FDA approved
RIPK1_HUMAN
ZINC - Substances
RIPK1_HUMAN
ZINC target
Q13546
PRO
Q13546
PDB
7CJB
,
5HX6
,
5V7Z
,
6HHO
,
4ITJ
,
4NEU
,
6C3E
,
6NW2
,
7XMK
,
5TX5
,
8I2N
,
6R5F
,
7FCZ
,
6NYH
,
6RLN
,
7YDX
,
4ITH
,
6C4D
,
4ITI
,
6AC5
,
6OCQ
,
7FD0
ZINC - Investigational
RIPK1_HUMAN
HPA
ENSG00000137275-RIPK1
GeneCards
Q13546
Ensembl
ENST00000259808
,
ENSP00000259808
,
ENST00000380409
,
ENSP00000369773
,
ENSG00000137275
Pharos - Targets
Q13546
ZINC - Predictions - Purchasable
RIPK1_HUMAN
HMDB Protein
HMDBP09499
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
0.972
27
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.959
30
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.928
12
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.893
9
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.892
11
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.884
10
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.877
7
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.837
9
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.798
8
UniProt:P0DTD1-PRO_0000449629 REP
0.788
6
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.703
5
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.697
5
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.602
5
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.602
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.589
2
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.564
3
UniProt:P04083 ANXA1
2
ANXA1 [cytosol]
(R-HSA-5263630)
ANXA1 [extracellular region]
(R-HSA-444539)
0.556
5
IntAct:EBI-4399559 UBIQ
0.544
3
UniProt:Q13107 USP4
1
USP4 [cytosol]
(R-HSA-5212663)
0.524
4
UniProt:Q8IVM0 CCD50
0.524
2
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.508
2
UniProt:B7UI21 NLEB1
0.508
4
UniProt:U5TQE9 U5TQE9
0.499
3
UniProt:Q96AB6 NTAN1
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text