Reactome | PSMD7 [cytosol]

PSMD7 [cytosol]

Stable Identifier

R-HSA-68806

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit S12, Proteasome subunit p40, Mov34 protein homolog, 26S proteasome regulatory subunit RPN8

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51665 PSMD7

Gene Names

PSMD7, MOV34L

Chain

chain:1-324

Reference Genes

BioGPS Gene:5713 PSMD7

COSMIC (genes):PSMD7 PSMD7

CTD Gene:5713 PSMD7

dbSNP Gene:5713 PSMD7

ENSEMBL:ENSG00000103035 PSMD7

HGNC:9565 PSMD7

KEGG:hsa:5713 PSMD7

Monarch:5713 PSMD7

NCBI Gene:5713 PSMD7

OMIM:157970 PSMD7

UCSC:P51665 PSMD7

Reference Transcript

RefSeq:NM_002811.4 PSMD7

Other Identifiers

11729113_a_at

11729114_s_at

11746059_a_at

16821021

201705_PM_at

201705_at

3668618

3668619

3668625

3668626

3668627

3668628

3668629

3668631

3668632

3668633

3668634

3668635

3668636

3668637

3668638

3668639

3668640

40276_at

5713

7997230

945_at

A_14_P114737

A_14_P123906

A_23_P106741

D50063_at

GE57237

GO:0000502

GO:0003824

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0008233

GO:0008237

GO:0016020

GO:0016787

GO:0030163

GO:0034774

GO:0042803

GO:0043161

GO:0043226

GO:0070062

GO:0140096

GO:1904813

HMNXSV003019799

ILMN_1776173

PH_hs_0025797

TC16000612.hg

g4506230_3p_at

Participates

as an input of

Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 (Homo sapiens)

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Homo sapiens)

Other forms of this molecule

PSMD7 [nucleoplasm]

PSMD7 [secretory granule lumen]

PSMD7 [extracellular region]

PSMD7 [ficolin-1-rich granule lumen]

Inferred To

RPN8 [cytosol] (Saccharomyces cerevisiae)

rpn-8 [cytosol] (Caenorhabditis elegans)

Rpn8 [cytosol] (Drosophila melanogaster)

PSMD7 [cytosol] (Bos taurus)

PSMD7 [cytosol] (Canis familiaris)

PSMD7 [cytosol] (Gallus gallus)

PSMD7 [cytosol] (Plasmodium falciparum)

PSMD7 [cytosol] (Sus scrofa)

Psmd7 [cytosol] (Mus musculus)

Psmd7 [cytosol] (Rattus norvegicus)

psmd7 [cytosol] (Danio rerio)

psmd7 [cytosol] (Xenopus tropicalis)

psmD7 [cytosol] (Dictyostelium discoideum)

rpn8 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002802.2

OpenTargets

ENSG00000103035

ENSEMBL

ENST00000219313, ENSP00000219313

HPA

ENSG00000103035-PSMD7

PRO

P51665

Pharos - Targets

P51665

GlyGen

P51665

PDB

5VHH, 2O95, 6WJN, 6MSG, 7QY7, 7QXX, 7W3F, 5VHS, 7W3C, 7QYB, 6WJD, 5VFP, 7QXU, 7W3B, 6MSJ, 7W3G, 5T0H, 7W3A, 7W3I, 5L4K, 6MSB, 7W39, 5T0I, 7QXW, 5VFS, 5VFQ, 7QYA, 2O96, 7W3K, 5T0C, 7W3M, 7QXN, 5VHI, 7QXP, 8CVT, 6MSD, 5GJQ, 7W3J, 5M32, 7W3H, 5VHF, 6MSK, 5T0G, 7W38, 6MSH, 5VGZ, 5GJR, 5T0J, 7W37, 5VFT, 5VFR, 5LN3, 5VFU

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.904	16
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.802	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.788	6
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.788	6
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.745	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	5
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.744	6
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.731	5
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.725	6
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.725	5
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.725	5
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.725	5
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.669	4
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9
UniProt:Q6PJG6 BRAT1			0.527	2
UniProt:Q5VIR6 VPS53	1	VPS53 [trans-Golgi network membrane] (R-HSA-6811031)	0.527	2
UniProt:Q86UP2 KTN1	4	KTN1 [plasma membrane] (R-HSA-9696518) KTN1 [endoplasmic reticulum membrane] (R-HSA-201604) p-KTN1 [endoplasmic reticulum lumen] (R-HSA-8956968) KTN1 [endoplasmic reticulum lumen] (R-HSA-8956694)	0.527	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	9
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.527	2
UniProt:O60826 CCDC22	2	CCDC22 [nucleoplasm] (R-HSA-8955644) CCDC22 [cytosol] (R-HSA-8955640)	0.527	2
UniProt:Q53HC0 CCD92			0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:Q01850 CDR2			0.527	2
UniProt:Q96EN9 REX1B			0.527	3
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.527	2
UniProt:P54252-1 ATXN3			0.499	2
UniProt:P04578-PRO_0000038427 ENV			0.462	2

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