Reactome | p-S218,S222-MAP2K1 [cytosol]

p-S218,S222-MAP2K1 [cytosol]

Stable Identifier

R-HSA-109837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S218,222-MEK1, Dual specificity mitogen-activated protein kinase kinase 1(phosphorylated), MAP kinase kinase 1(phosphorylated), p-S218,222-MAPKK 1, ERK activator kinase 1(phosphorylated), MAPK/ERK kinase 1

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External Reference Information

External Reference

UniProt:Q02750 MAP2K1

Gene Names

MAP2K1, MEK1, PRKMK1

Chain

chain:1-393

Reference Genes

BioGPS Gene:5604 MAP2K1

COSMIC (genes):MAP2K1 MAP2K1

CTD Gene:5604 MAP2K1

dbSNP Gene:5604 MAP2K1

ENSEMBL:ENSG00000169032 MAP2K1

HGNC:6840 MAP2K1

KEGG Gene (Homo sapiens):5604 MAP2K1

Monarch:5604 MAP2K1

NCBI Gene:5604 MAP2K1

OMIM:176872 MAP2K1

UCSC:Q02750 MAP2K1

Reference Transcript

Other Identifiers

0001740347

1130_at

11717291_a_at

11749555_a_at

11757478_s_at

16802190

1844_s_at

1S9J

202670_at

26430

2P55

3092255

3092256

3092263

3092264

3598663

3598664

3598670

3598671

3598672

3598673

3598688

3598690

3598691

3598692

3598696

3598697

3598700

3598701

3598702

3834

3DV3

3DY7

3E8N

3EQB

3EQC

3EQD

3EQF

3EQG

3EQH

3EQI

3MBL

3ORN

3OS3

3PP1

3SLS

3V01

3V04

3VVH

3W8Q

3WIG

3ZLS

3ZLW

3ZLX

3ZLY

3ZM4

4AN2

4AN3

4AN9

4ANB

4ARK

4LMN

4MNE

4U7Z

4U80

4U81

5604

5BX0

5EYM

5HZE

5YT3

7984319

A4QPA9

A_23_P20248

AAA36318

AAI37460

AAI39730

AK291500

BAF84189

BC137459

BC139729

CAB003834

CCDS10216

CH471082

EAW77765

ENSG00000169032

ENSP00000302486

ENST00000307102

ENST00000307102.9

EntrezGene:5604

EntrezGene:MAP2K1

GE57608

GO:0000003

GO:0000165

GO:0000166

GO:0000187

GO:0000902

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006935

GO:0006950

GO:0007049

GO:0007050

GO:0007165

GO:0007507

GO:0007568

GO:0008022

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009790

GO:0010628

GO:0010629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018107

GO:0018108

GO:0021697

GO:0023014

GO:0030154

GO:0030182

GO:0030216

GO:0030234

GO:0030878

GO:0031098

GO:0031410

GO:0032147

GO:0032872

GO:0034641

GO:0040011

GO:0043167

GO:0043226

GO:0043539

GO:0045597

GO:0045893

GO:0047485

GO:0048538

GO:0048646

GO:0048679

GO:0048856

GO:0048870

GO:0050772

GO:0060020

GO:0060324

GO:0060425

GO:0060440

GO:0060502

GO:0060674

GO:0060711

GO:0070371

GO:0070374

GO:0071902

GO:0090170

GO:0090398

GO:0097110

GO:1903800

GO:2000641

H3BRW9

HGNC:6840

HPA026430

Hs.3446.0.A2_3p_at

ILMN_1694240

IPR000719

IPR008271

IPR011009

IPR017441

L05624

L05624_s_at

L11284

L11284_at

LRG_725

LRG_725t1

MAP2K1

MAP2K1-201

MIM:163950

MIM:176872

MIM:615279

NM_002755

NP_002746

PF00069

PH_hs_0022483

SM00220

TC15000613.hg

UPI000013EBC9

XM_011521783

XM_017022411

XM_017022412

XP_011520085

XP_016877900

XP_016877901

Participant Of

hasComponent

hasMember

input

MAP2K1 binds MAPK3

output

Dissociation of p-T,Y-MAPK3:MAP2K1

Other forms of this molecule

MAP2K1(9-393) [cytosol]

MAP2K1(2-8) [cytosol]

p-S,218, S222,T292 MAP2K1 [cytosol]

p-T286,T292-MAP2K1 [cytosol]

p-S218,S222,T286,T292-MAP2K1 [cytosol]

MAP2K1 [cytosol]

Inferred To

Phospho Mek1 [cytosol] (Mus musculus)

phospho-p-S218,S222-MAP2K1 [cytosol] (Bos taurus)

phospho-p-S218,S222-MAP2K1 [cytosol] (Caenorhabditis elegans)

phospho-p-S218,S222-MAP2K1 [cytosol] (Canis familiaris)

phospho-p-S218,S222-MAP2K1 [cytosol] (Danio rerio)

phospho-p-S218,S222-MAP2K1 [cytosol] (Dictyostelium discoideum)

phospho-p-S218,S222-MAP2K1 [cytosol] (Drosophila melanogaster)

phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)

phospho-p-S218,S222-MAP2K1 [cytosol] (Plasmodium falciparum)

phospho-p-S218,S222-MAP2K1 [cytosol] (Rattus norvegicus)

phospho-p-S218,S222-MAP2K1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S218,S222-MAP2K1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S218,S222-MAP2K1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 218

Coordinate

218

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 222

Coordinate

222

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016877900.1, NP_002746.1

ZINC - World Drugs

MP2K1_HUMAN

OpenTargets

ENSG00000169032

ZINC - FDA approved

MP2K1_HUMAN

ZINC - Substances

MP2K1_HUMAN

ZINC - Biogenic

MP2K1_HUMAN

ZINC target

Q02750

PRO

Q02750

PDB

3ZLS, 3E8N, 3W8Q, 3EQB, 4AN2, 4AN3, 5YT3, 3EQH, 5HZE, 3ORN, 3OS3, 3EQI, 4LMN, 4ARK, 3DV3, 3MBL, 3DY7, 3EQF, 2P55, 4AN9, 3EQG, 3ZLY, 3PP1, 4U81, 4ANB, 4U7Z, 4U80, 3ZLX, 3EQC, 3SLS, 4MNE, 3ZLW, 3EQD, 3WIG, 1S9J, 3ZM4, 3V04, 3V01, 3VVH, 5BX0, 5EYM

ZINC - Investigational

MP2K1_HUMAN

ZINC - Metabolites

MP2K1_HUMAN

GeneCards

Q02750

Orphanet

16377

ZINC - Predictions - Purchasable

MP2K1_HUMAN

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.976	58
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.952	35
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.69	5
UniProt:Q8IVT5 KSR1	5	KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654) p-S311 KSR1 [cytosol] (R-HSA-5672652) p-S311,Y552 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y552 KSR1 [cytosol] (R-HSA-5672656)	0.643	7
UniProt:P28482 MAPK1	7	MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.609	2
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.556	3
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q86Y07 VRK2			0.524	2
UniProt:Q61097	5	KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y552 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y552 KSR1 [cytosol] (R-MMU-5672656)	0.508	2
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.508	5
UniProt:Q86Y07-1 VRK2			0.499	2
UniProt:P27361 MAPK3	4	p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724)	0.499	2
UniProt:Q8WWU5-7 TCP11			0.488	2
UniProt:Q8N9N5-2 BANP			0.488	2
UniProt:Q9H8W4 PKHF2			0.488	2
UniProt:Q49A26-4 GLYR1			0.488	2
UniProt:Q96S96 PEBP4			0.462	3
UniProt:O75832 PSMD10	2	PSMD10 [cytosol] (R-HSA-68788) PSMD10 [nucleoplasm] (R-HSA-174322)	0.462	2