Reactome | PSMB1 [cytosol]

PSMB1 [cytosol]

Stable Identifier

R-HSA-68738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit beta-6

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20618 PSMB1

Gene Names

PSMB1, PSC5

Chain

propeptide:1-28, chain:29-241

Reference Genes

BioGPS Gene:5689 PSMB1

COSMIC (genes):PSMB1 PSMB1

CTD Gene:5689 PSMB1

dbSNP Gene:5689 PSMB1

ENSEMBL:ENSG00000008018 PSMB1

HGNC:9537 PSMB1

KEGG:hsa:5689 PSMB1

Monarch:5689 PSMB1

NCBI Gene:5689 PSMB1

OMIM:602017 PSMB1

UCSC:P20618 PSMB1

Reference Transcript

RefSeq:NM_002793.3 PSMB1

Other Identifiers

11715943_x_at

11754482_a_at

1447_at

17026002

200876_PM_s_at

200876_s_at

214288_PM_s_at

214288_s_at

2986502

2986503

2986504

2986506

2986510

2986511

2986514

2986515

2986516

2986521

2986522

5689

8130952

A_23_P156531

A_24_P233570

D00761_at

GE79695

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0019774

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003007545

ILMN_1789176

PH_hs_0023954

TC06002343.hg

g4506192_3p_a_at

Participates

as a component of

20S CP inner ring [cytosol] (Homo sapiens)

Other forms of this molecule

PSMB1 [nucleoplasm]

PSMB1 [secretory granule lumen]

PSMB1 [extracellular region]

PSMB1 [ficolin-1-rich granule lumen]

pro-PSMB1 [cytosol]

PSMB1(1-28) [cytosol]

Inferred To

Psmb1 [cytosol] (Mus musculus)

Psmb1 [cytosol] (Rattus norvegicus)

PSMB1 [cytosol] (Bos taurus)

PSMB1 [cytosol] (Canis familiaris)

PSMB1 [cytosol] (Gallus gallus)

PSMB1 [cytosol] (Sus scrofa)

Ghost homologue of PSMB1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PSMB1 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PSMB1 [cytosol] (Drosophila melanogaster)

Ghost homologue of PSMB1 [cytosol] (Plasmodium falciparum)

Ghost homologue of PSMB1 [cytosol] (Saccharomyces cerevisiae)

pam1 [cytosol] (Schizosaccharomyces pombe)

psmb1 [cytosol] (Danio rerio)

psmb1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002784.1

ZINC - World Drugs

PSB1_HUMAN

Guide to Pharmacology - Targets

2404

OpenTargets

ENSG00000008018

ENSEMBL

ENST00000262193, ENSP00000262193

ZINC - FDA approved

PSB1_HUMAN

ZINC - Substances

PSB1_HUMAN

ZINC target

P20618

PRO

P20618

GlyGen

P20618

PDB

7W38, 5T0J, 7W3H, 5T0H, 7NHT, 7W3A, 7QXU, 7NAN, 8QZ9, 5VFU, 5VFQ, 6MSJ, 7V5M, 6RGQ, 5L5W, 5L60, 5LEY, 5L5B, 6WJD, 5L5Z, 5L5P, 5L5D, 5L5T, 5LEZ, 7PG9, 6R70, 5LE5, 7QY7, 7QXP, 8CVS, 7V5G, 7NAO, 7W3G, 7NAQ, 5M32, 7W3I, 6MSG, 6WJN, 5VFS, 5VFR, 8UD9, 6MSK, 6AVO, 5L5O, 5L64, 5LF4, 8CXB, 5L5I, 7QYB, 5L5X, 5L62, 5L5U, 6REY, 5LF6, 5L5J, 7W3M, 6MSD, 7W3C, 5M2B, 6MSB, 7W3B, 5VFO, 6KWY, 8QYO, 8QYS, 7W39, 5T0C, 7QXW, 5VFT, 5A0Q, 5L5S, 7AWE, 5LEX, 8BZL, 7QYA, 5LF1, 5L5Q, 5L5Y, 5LF7, 5L5E, 5L63, 8CVR, 6MSE, 7QXX, 7QXN, 8QYN, 5VFP, 5T0I, 7W3J, 5T0G, 7W37, 5GJR, 6MSH, 7NAP, 5LN3, 7B12, 6XMJ, 7LXV, 5L5V, 5L5H, 6E5B, 5L61, 5L5F, 5LF0, 5LF3, 5L5R, 4R67, 5L4G, 4R3O, 7W3K, 8CVT, 7W3F, 5GJQ

ZINC - Investigational

PSB1_HUMAN

HPA

ENSG00000008018-PSMB1

Pharos - Targets

P20618

ZINC - Predictions - Purchasable

PSB1_HUMAN

Interactors (123)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.929	16
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.85	13
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.804	7
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.804	6
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.804	6
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.8	9
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.798	8
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.795	8
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.788	9
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.781	7
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.781	7
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.725	5
UniProt:Q9BVG8 KIFC3			0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.643	4
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.643	5
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.643	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.643	6
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.643	5
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.643	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.643	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.643	3
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.643	5
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.643	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.638	3
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	3
UniProt:Q9H079 KTBL1			0.556	5
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.556	3
UniProt:Q5SQQ9-2 VAX1			0.556	3
UniProt:Q9NUG4 CCM2L			0.556	3
UniProt:Q12824-2 SMARCB1			0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:P78356-2 PIP4K2B			0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q6PID6 TTC33			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q58EX7 PLEKHG4	1	PLEKHG4 [cytosol] (R-HSA-9679579)	0.556	3
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:Q9NP55 BPIFA1	1	BPIFA1 [extracellular region] (R-HSA-6809280)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:P60323-2 P603232			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9UPY8 MARE3			0.556	3
UniProt:Q9UIY3 RWD2A			0.556	3
UniProt:Q9NQ48 LZTFL1	1	LZTFL1 [cytosol] (R-HSA-5617789)	0.556	3
UniProt:Q6GQQ9 OTUD7B	1	OTUD7B [cytosol] (R-HSA-5212662)	0.556	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.556	3
UniProt:Q96C01 F136A			0.556	3
UniProt:Q16740 CLPP	1	CLPP [mitochondrial matrix] (R-HSA-9838002)	0.556	3
UniProt:Q93045 STMN2	1	STMN2 [cytosol] (R-HSA-9696513)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q13555-5 CAMK2G			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q8TBB0 THAP6			0.556	3
UniProt:Q8WTU0 DDI1			0.556	3
UniProt:Q9UIA0 CYTH4	2	CYTH4 [cytosol] (R-HSA-8847839) CYTH4 [Golgi membrane] (R-HSA-8847837)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:P57055 DSCR6			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.556	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.556	3
UniProt:P0C7X2 ZNF688	1	ZNF688 [nucleoplasm] (R-HSA-2248884)	0.556	3
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.556	3
UniProt:Q9HCM9-2 TRIM39			0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:Q9NZD4 AHSP			0.556	3
UniProt:Q3LI76 KRTAP15-1	1	KRTAP15-1 [cytosol] (R-HSA-6810304)	0.556	3
UniProt:Q7Z7F0-4 KHDC4			0.556	3
UniProt:Q86WP2 GPBP1			0.556	3
UniProt:P78358 CTG1B			0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:Q8IUC3 KRA71			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q53H96 PYCRL	1	PYCR3 [cytosol] (R-HSA-6783934)	0.556	3
UniProt:Q6NTE8 MRNIP			0.556	3
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.556	3
UniProt:Q8NB16-2 MLKL			0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:O43679 LDB2			0.556	3
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:Q5T754 LCE1F	1	LCE1F [cytosol] (R-HSA-6814270)	0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:O60729 CDC14B	1	CDC14B [nucleoplasm] (R-HSA-3214897)	0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q13360-2 ZNF177			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q6ZMJ2-2 SCARA5			0.556	3
UniProt:A0A0C4DGF1 A0A0C4DGF1			0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	5
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q9HAP6 LIN7B	2	LIN7B [plasma membrane] (R-HSA-5216107) LIN7B [transport vesicle membrane] (R-HSA-9610415)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	5
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.556	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:Q9P2X3 IMPACT	1	IMPACT [cytosol] (R-HSA-9634678)	0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [specific granule lumen] (R-HSA-6799719) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [azurophil granule lumen] (R-HSA-6799709)	0.556	3
UniProt:Q9GZU8 PIP30			0.527	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.527	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	3
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	4
UniProt:Q15555 MARE2			0.508	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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