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What is Reactome ?
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PSMB1 [cytosol]
Stable Identifier
R-HSA-68738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proteasome subunit beta type 1 , Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Proteasome mediated degradation of COP1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Proteasome mediated degradation of Cyclin D1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
CDT1 association with the CDC6:ORC:origin complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD (Homo sapiens)
processing defective Hh variants are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Proteosome-mediated degradation of APOBEC3G (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Degradation of ubiquitinated CD4 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
Proteasomal clevage of exogenous antigen (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
26Sproteasome degrades K48polyUb-NIK (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
26S proteosome degrades ODC holoenzyme complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1:mRNA complex is destroyed (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1 binds 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
ADRM1:26S proteaseome binds USP14 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Neddylation (Homo sapiens)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
ub-GLI is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
PRICKLE1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Degradation of DVL (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20618 PSMB1
Gene Names
PSMB1, PSC5
Chain
propeptide:1-28, chain:29-241
Reference Genes
BioGPS Gene:5689 PSMB1
COSMIC (genes):PSMB1 PSMB1
CTD Gene:5689 PSMB1
dbSNP Gene:5689 PSMB1
ENSEMBL:ENSG00000008018 PSMB1
HGNC:9537 PSMB1
KEGG Gene (Homo sapiens):5689 PSMB1
Monarch:5689 PSMB1
NCBI Gene:5689 PSMB1
OMIM:602017 PSMB1
UCSC:P20618 PSMB1
Reference Transcript
RefSeq:NM_002793.3 PSMB1
Other Identifiers
0003870136
11715943_x_at
11754482_a_at
1447_at
17026002
200876_s_at
214288_s_at
29635
29637
2986503
2986504
2986506
2986510
2986511
2986514
2986515
2986521
2986522
33911
4R3O
4R67
5689
5A0Q
5GJQ
5GJR
5L4G
5L5B
5L5D
5L5E
5L5F
5L5H
5L5I
5L5J
5L5O
5L5P
5L5Q
5L5R
5L5S
5L5T
5L5U
5L5V
5L5W
5L5X
5L5Y
5L5Z
5L60
5L61
5L62
5L63
5L64
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M2B
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
8130952
A0A140VK45
A_23_P156531
A_24_P233570
AAH00508
AAH20807
AAV38525
AB451312
AB451442
AEE61182
AL031259
BAA00658
BAG70126
BAG70256
BC000508
BC020807
BT019720
CAB033911
CCDS34577
D00761
D00761_at
ENSG00000008018
ENSP00000262193
ENST00000262193
ENST00000262193.6
EntrezGene:5689
EntrezGene:PSMB1
g4506192_3p_a_at
GE79695
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006508
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0010498
GO:0010499
GO:0010972
GO:0016032
GO:0016192
GO:0016579
GO:0016787
GO:0019774
GO:0030154
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
HGNC:9537
HM005585
HPA029635
HPA029637
ILMN_1789176
IPR001353
IPR016050
IPR023333
IPR029055
IPR035202
MIM:602017
NM_002793
NP_002784
PF00227
PH_hs_0023954
PSMB1
PSMB1-201
TC06002343.hg
UPI000013259C
Participant Of
hasComponent
26S proteasome [cytosol]
Other forms of this molecule
PSMB1 [secretory granule lumen]
PSMB1 [extracellular region]
PSMB1 [ficolin-1-rich granule lumen]
PSMB1 [nucleoplasm]
Inferred To
PSMB1 [cytosol] (Caenorhabditis elegans)
PSMB1 [cytosol] (Canis familiaris)
PSMB1 [cytosol] (Danio rerio)
PSMB1 [cytosol] (Dictyostelium discoideum)
PSMB1 [cytosol] (Drosophila melanogaster)
PSMB1 [cytosol] (Mus musculus)
PSMB1 [cytosol] (Plasmodium falciparum)
PSMB1 [cytosol] (Rattus norvegicus)
PSMB1 [cytosol] (Saccharomyces cerevisiae)
PSMB1 [cytosol] (Schizosaccharomyces pombe)
PSMB1 [cytosol] (Sus scrofa)
PSMB1 [cytosol] (Xenopus tropicalis)
Ghost homologue of PSMB1 [cytosol] (Bos taurus)
Cross References
ZINC - Investigational
PSB1_HUMAN
RefSeq
NP_002784.1
ZINC - World Drugs
PSB1_HUMAN
OpenTargets
ENSG00000008018
ZINC - FDA approved
PSB1_HUMAN
GeneCards
P20618
ZINC - Substances
PSB1_HUMAN
ZINC target
P20618
PRO
P20618
ZINC - Predictions - Purchasable
PSB1_HUMAN
PDB
5VFO
,
5L63
,
5T0C
,
5VFQ
,
6MSD
,
5LF3
,
5LEY
,
5LF6
,
6MSJ
,
5L5D
,
5L5U
,
5L5S
,
5VFS
,
5T0H
,
6MSG
,
5T0J
,
5L5W
,
5M2B
,
5L60
,
5GJR
,
5L5Y
,
5L5J
,
5LF1
,
5L5H
,
5L5P
,
5VFU
,
5LF7
,
4R3O
,
5VFP
,
5L64
,
6MSB
,
5VFR
,
5L5R
,
5LEX
,
5LF4
,
4R67
,
5LEZ
,
5L62
,
5L5V
,
6MSK
,
5L5B
,
5L5T
,
5LE5
,
6MSE
,
5T0G
,
5VFT
,
5T0I
,
5L5X
,
6MSH
,
5L5E
,
6AVO
,
5GJQ
,
5L5F
,
5M32
,
5LF0
,
5LN3
,
5L5I
,
5L61
,
5L5Q
,
5L5O
,
5L5Z
,
5L4G
,
5A0Q
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.696
5
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.696
5
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.488
2
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
0.488
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
0.488
2
UniProt:P84022 SMAD3
12
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
0.488
2
UniProt:Q9HAP6 LIN7B
3
LIN7B [transport vesicle membrane]
(R-HSA-9610415)
LIN7B [plasma membrane]
(R-HSA-5216107)
LIN7B [plasma membrane]
(R-HSA-6794260)
0.488
2
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.488
2
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