Reactome | SMAD4 [nucleoplasm]

SMAD4 [nucleoplasm]

Stable Identifier

R-HSA-177103

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Co-SMAD, Mothers against decapentaplegic homolog 4

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13485 SMAD4

Gene Names

SMAD4, DPC4, MADH4

Chain

chain:1-552

Reference Genes

BioGPS Gene:4089 SMAD4

COSMIC (genes):SMAD4 SMAD4

CTD Gene:4089 SMAD4

dbSNP Gene:4089 SMAD4

ENSEMBL:ENSG00000141646 SMAD4

ENSEMBL:ENSG00000141646.15 SMAD4

HGNC:6770 SMAD4

KEGG Gene (Homo sapiens):4089 SMAD4

Monarch:4089 SMAD4

NCBI Gene:4089 SMAD4

OMIM:600993 SMAD4

UCSC:Q13485 SMAD4

Reference Transcript

RefSeq:NM_005359.5 SMAD4

Other Identifiers

11725360_a_at

11725361_s_at

11725362_x_at

11725363_s_at

11744679_a_at

11750827_a_at

11753117_a_at

16852354

202526_PM_at

202526_at

202527_PM_s_at

202527_s_at

235725_PM_at

235725_at

36953_at

3788304

3788305

3788306

3788307

3788308

3788315

3788316

3788318

3788320

3788324

3788327

3788328

3788330

3788335

3788337

3788344

3788346

3788347

3788348

3788349

3788350

3788351

3788353

3788355

3788357

3788358

3788359

4089

46885_at

509_at

510_g_at

57902_at

58962_at

74813_at

8021228

A_14_P134632

A_19_P00323665

A_19_P00804817

A_19_P00812250

A_23_P27346

GE887174

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001223

GO:0001228

GO:0001541

GO:0001649

GO:0001658

GO:0001666

GO:0001701

GO:0001702

GO:0001822

GO:0001837

GO:0003012

GO:0003148

GO:0003161

GO:0003190

GO:0003198

GO:0003220

GO:0003251

GO:0003279

GO:0003360

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005518

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006879

GO:0007010

GO:0007179

GO:0007183

GO:0007283

GO:0007338

GO:0007369

GO:0007411

GO:0007492

GO:0007498

GO:0008092

GO:0008283

GO:0008285

GO:0008584

GO:0008585

GO:0009653

GO:0009952

GO:0010468

GO:0010614

GO:0010631

GO:0010666

GO:0010718

GO:0010862

GO:0012501

GO:0014033

GO:0017015

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030308

GO:0030325

GO:0030509

GO:0030511

GO:0030513

GO:0031005

GO:0032444

GO:0032525

GO:0032909

GO:0032924

GO:0032991

GO:0033686

GO:0035556

GO:0036211

GO:0036302

GO:0042118

GO:0042127

GO:0042177

GO:0042733

GO:0042802

GO:0042803

GO:0043199

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0045944

GO:0046332

GO:0046872

GO:0046881

GO:0048382

GO:0048589

GO:0048663

GO:0048729

GO:0048733

GO:0048856

GO:0048859

GO:0048870

GO:0050886

GO:0051098

GO:0051571

GO:0051797

GO:0055065

GO:0060065

GO:0060391

GO:0060395

GO:0060412

GO:0060956

GO:0061040

GO:0061629

GO:0062009

GO:0065003

GO:0070102

GO:0070371

GO:0070373

GO:0070411

GO:0070412

GO:0071141

GO:0071144

GO:0071333

GO:0071559

GO:0071773

GO:0072133

GO:0072134

GO:0072520

GO:0090575

GO:0140110

GO:1901522

GO:1902895

GO:1905305

GO:2000617

HMNXSV003050274

Hs.50438.0.A1_3p_at

Hs.75862.0.S2_3p_at

ILMN_1741477

ILMN_1842785

PH_hs_0004380

TC18000998.hg

U44378_at

g4885456_3p_a_at

Participates

as an output of

as a component of

Other forms of this molecule

SMAD4 P356R [cytosol]

SMAD4 K428T [cytosol]

SMAD4 D351del [cytosol]

SMAD4 R361H [cytosol]

SMAD4 P356L [cytosol]

SMAD4 A406T [cytosol]

SMAD4 D351Y [cytosol]

SMAD4 D351H [cytosol]

SMAD4 R361C [cytosol]

SMAD4 D351G [cytosol]

SMAD4 R515T [cytosol]

SMAD4 G352* [cytosol]

SMAD4 S178* [cytosol]

SMAD4 G477* [cytosol]

SMAD4 G473* [cytosol]

SMAD4 S144* [cytosol]

SMAD4 E538* [cytosol]

SMAD4 E390* [cytosol]

SMAD4 S154* [cytosol]

SMAD4 E330* [cytosol]

SMAD4 E417* [cytosol]

SMAD4 Y195* [cytosol]

SMAD4 E108* [cytosol]

SMAD4 S343* [cytosol]

SMAD4 E520* [cytosol]

SMAD4 G510* [cytosol]

SMAD4 G358* [cytosol]

SMAD4 E175* [cytosol]

SMAD4 E307* [cytosol]

SMAD4 E53* [cytosol]

SMAD4 S171* [cytosol]

SMAD4 G30* [cytosol]

SMAD4 G168* [cytosol]

SMAD4 Q366* [cytosol]

SMAD4 R135* [cytosol]

SMAD4 L146* [cytosol]

SMAD4 L440* [cytosol]

SMAD4 Q183* [cytosol]

SMAD4 Q289* [cytosol]

SMAD4 Q248* [cytosol]

SMAD4 Q249* [cytosol]

SMAD4 Q256* [cytosol]

SMAD4 Q239* [cytosol]

SMAD4 Q245* [cytosol]

SMAD4 Q224* [cytosol]

SMAD4 W509* [cytosol]

SMAD4 Q311* [cytosol]

SMAD4 W398* [cytosol]

SMAD4 Q250* [cytosol]

SMAD4 Q410* [cytosol]

SMAD4 Q534* [cytosol]

SMAD4 Q83* [cytosol]

SMAD4 Q448* [cytosol]

SMAD4 K428R [cytosol]

SMAD4 Q455* [cytosol]

SMAD4 R445* [cytosol]

SMAD4 Q442* [cytosol]

SMAD4 Q516* [cytosol]

SMAD4 C443* [cytosol]

SMAD4 Q334* [cytosol]

SMAD4 R361G [cytosol]

SMAD4 L172* [cytosol]

SMAD4 K122* [cytosol]

SMAD4 R361S [cytosol]

SMAD4 Y430* [cytosol]

SMAD4 Y260* [cytosol]

SMAD4 Y95* [cytosol]

SMAD4 Y322* [cytosol]

SMAD4 E321* [cytosol]

SMAD4 Y412* [cytosol]

SMAD4 R515* [cytosol]

SMAD4 Y328* [cytosol]

SMAD4 E33* [cytosol]

SMAD4 Y513* [cytosol]

SMAD4 E526* [cytosol]

SMAD4 S138* [cytosol]

SMAD4 Y276* [cytosol]

SMAD4 E205* [cytosol]

SMAD4 E49* [cytosol]

SMAD4 W101* [cytosol]

SMAD4 W268* [cytosol]

SMAD4 Q116* [cytosol]

SMAD4 S242* [cytosol]

SMAD4 W302* [cytosol]

SMAD4 W524* [cytosol]

SMAD4 [cytosol]

Ub-SMAD4 [cytosol]

Ub-SMAD4 [nucleoplasm]

RibC-SMAD4 [nucleoplasm]

Inferred To

Med [nucleoplasm] (Drosophila melanogaster)

daf-3 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of SMAD4 [nucleoplasm] (Gallus gallus)

Homologues of SMAD4 [nucleoplasm] (Caenorhabditis elegans)

SMAD4 [nucleoplasm] (Bos taurus)

SMAD4 [nucleoplasm] (Caenorhabditis elegans)

SMAD4 [nucleoplasm] (Canis familiaris)

SMAD4 [nucleoplasm] (Danio rerio)

SMAD4 [nucleoplasm] (Mus musculus)

SMAD4 [nucleoplasm] (Rattus norvegicus)

SMAD4 [nucleoplasm] (Sus scrofa)

smad4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005350.1

OpenTargets

ENSG00000141646

GeneCards

Q13485

HPA

ENSG00000141646-SMAD4

Ensembl

ENST00000398417, ENST00000342988, ENSG00000141646, ENSP00000381452, ENSP00000341551

PRO

Q13485

Pharos - Targets

Q13485

Orphanet

15524

HMDB Protein

HMDBP14469

PDB

5C4V, 1DD1, 5MF0, 1G88, 5MEZ, 1MR1, 1YGS, 5MEY, 1U7V, 6YIC, 1U7F, 5UWU

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.98	35
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.962	23
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468)	0.946	12
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.91	13
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.835	6
UniProt:P61968 LMO4			0.83	8
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.779	5
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.748	6
UniProt:O15198 SMAD9	3	p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441) SMAD9 [cytosol] (R-HSA-201478)	0.748