Reactome | p-BRAF F595L [plasma membrane]

p-BRAF F595L [plasma membrane]

Stable Identifier

R-HSA-8936641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

B-RAF

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] (Homo sapiens)
        
        phosphorylated moderate kinase activity BRAF mutants [plasma membrane] (Homo sapiens)
        
        p-BRAF F595L [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
16439621	Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome Rodriguez-Viciana, P, Tetsu, O, Tidyman, WE, Estep, AL, Conger, BA, Cruz, MS, McCormick, F, Rauen, KA	Science	2006
12068308	Mutations of the BRAF gene in human cancer Davies, H, Bignell, GR, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, MJ, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Wilson, R, Jayatilake, H, Gusterson, BA, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, GJ, Bigner, DD, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, JW, Leung, SY, Yuen, ST, Weber, BL, Seigler, HF, Darrow, TL, Paterson, H, Marais, R, Marshall, CJ, Wooster, R, Stratton, MR, Futreal, PA	Nature	2002
19206169	Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum Sarkozy, A, Carta, C, Moretti, S, Zampino, G, Digilio, MC, Pantaleoni, F, Scioletti, AP, Esposito, G, Cordeddu, V, Lepri, F, Petrangeli, V, Dentici, ML, Mancini, GM, Selicorni, A, Rossi, C, Mazzanti, L, Marino, B, Ferrero, GB, Silengo, MC, Memo, L, Stanzial, F, Faravelli, F, Stuppia, L, Puxeddu, E, Gelb, BD, Dallapiccola, B, Tartaglia, M	Hum. Mutat.	2009
15035987	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R	Cell	2004

External Reference Information

External Reference

UniProt:P15056 BRAF

Gene Names

BRAF, BRAF1, RAFB1

Chain

initiator methionine:1, chain:2-766

Reference Genes

BioGPS Gene:673 BRAF

COSMIC (genes):BRAF BRAF

CTD Gene:673 BRAF

dbSNP Gene:673 BRAF

ENSEMBL:ENSG00000157764 BRAF

HGNC:1097 BRAF

KEGG Gene (Homo sapiens):673 BRAF

Monarch:673 BRAF

NCBI Gene:673 BRAF

OMIM:164757 BRAF

UCSC:P15056 BRAF

Reference Transcript

RefSeq:NM_004333.4 BRAF

Other Identifiers

11732491_s_at

1654_at

17063631

1UWH

1UWJ

206044_s_at

2FB8

2L05

3076364

3076365

3076366

3076367

3076368

3076370

3076372

3076374

3076375

3076380

3076381

3076382

3076383

3076384

3076386

3076388

3076392

3076393

3076396

3076399

3076414

3076416

3076439

3076440

3076441

3076442

3982166

3982173

3C4C

3D4Q

3IDP

3II5

3NY5

3OG7

3PPJ

3PPK

3PRF

3PRI

3PSB

3PSD

3Q4C

3Q96

3SKC

3TV4

3TV6

40306_at

4CQE

4DBN

4E26

4E4X

4EHE

4EHG

4FC0

4FK3

4G9C

4G9R

4H58

4JVG

4KSP

4KSQ

4MBJ

4MNE

4MNF

4PP7

4R5Y

4RZV

4RZW

4WO5

4XV1

4XV2

4XV3

4XV9

4YHT

5C9C

5CSW

5CSX

5CT7

5FD2

5HI2

5HID

5HIE

5ITA

5J17

5J18

5J2R

5JRQ

5JSM

5JT2

5VAL

5VAM

5VR3

5VYK

673

6B8U

6CAD

8143417

86199_r_at

A0A2R8Y467

A0A2R8Y679

A0A2R8Y8E0

A0A2R8YDP5

A0A2R8YES9

A0A2U3TZI2

A_23_P42935

AAA35609

AAA96495

AAD15551

AAD43193

AAI01758

AAI12080

AC006344

AC006347

ACD11489

AM989472

AM989473

AM989474

AM989475

AM989476

AM989477

BC101757

BC112079

BRAF

BRAF-220

CAA46301

CAB004552

CAQ43111

CAQ43112

CAQ43113

CAQ43114

CAQ43115

CAQ43116

CCDS5863

CH236950

EAL24023

ENSG00000157764

ENSP00000493543

ENST00000646891

ENST00000646891.1

EntrezGene:673

EntrezGene:BRAF

EU600171

g4757867_3p_a_at

GE58163

GE766137

GO:0000165

GO:0000166

GO:0000186

GO:0003674

GO:0004672

GO:0004674

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005975

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009887

GO:0010628

GO:0010828

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0033138

GO:0035556

GO:0042802

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0046872

GO:0046982

GO:0048856

GO:0055085

GO:0070374

GO:0070413

GO:0071277

GO:0090150

H7C560

H7C5K3

HGNC:1097

HPA001328

HPA071048

ILMN_1652472

IPR000719

IPR001245

IPR002219

IPR003116

IPR008271

IPR011009

IPR017441

IPR020454

IPR029071

LRG_299

M21001

M95712

M95712_at

MIM:115150

MIM:163950

MIM:164757

MIM:211980

MIM:613706

MIM:613707

NM_004333

NP_004324

PF00130

PF02196

PF07714

PH_hs_0027912

PR00008

SM00109

SM00220

SM00455

TC07001927.hg

UPI000013DF26

X65187

Participant Of

hasMember

phosphorylated moderate kinase activity BRAF mutants [plasma membrane]

Other forms of this molecule

p-S,T-BRAF [cytosol]

BRAF-MACF1fusion [cytosol]

p-BRAF-MACF1 fusion [cytosol]

BRAF E501G [cytosol]

BRAF D594N [cytosol]

BRAF D638E [cytosol]

BRAF G596R [cytosol]

BRAF D594V [cytosol]

BRAF G596V [cytosol]

BRAF G466E [cytosol]

BRAF D594G [cytosol]

BRAF L505H [cytosol]

BRAF F595L [cytosol]

BRAF L597V [cytosol]

BRAF G464E [cytosol]

BRAF N581D [cytosol]

BRAF E586K [cytosol]

BRAF V600K [cytosol]

BRAF A246P [cytosol]

BRAF G469V [cytosol]

BRAF T244P [cytosol]

BRAF G469R [cytosol]

BRAF L597R [cytosol]

BRAF G469E [cytosol]

BRAF L597Q [cytosol]

BRAF G466A [cytosol]

BRAF G466V [cytosol]

BRAF N581S [cytosol]

BRAF G464V [cytosol]

p-BRAF L597V [plasma membrane]

p-BRAF L505H [plasma membrane]

p-BRAF G464E [plasma membrane]

p-BRAF A246P [plasma membrane]

p-BRAF E586K [plasma membrane]

p-BRAF N581D [plasma membrane]

p-BRAF V600K [plasma membrane]

p-BRAF G464V [plasma membrane]

p-BRAF T244P [plasma membrane]

p-BRAF G469E [plasma membrane]

p-BRAF G466V [plasma membrane]

p-BRAF G469V [plasma membrane]

p-BRAF G466A [plasma membrane]

p-BRAF L597Q [plasma membrane]

p-BRAF L597R [plasma membrane]

p-BRAF N581S [plasma membrane]

p-BRAF G469R [plasma membrane]

BRAF 599dupT [cytosol]

BRAF G534R [cytosol]

BRAF S467A [cytosol]

BRAF K601N [cytosol]

BRAF G469A [cytosol]

BRAF L485F [cytosol]

BRAF Q257R [cytosol]

BRAF K499E [cytosol]

BRAF V600E [cytosol]

BRAF K601E [cytosol]

BRAF V600E V169_M438del [cytosol]

BRAF V600E V47_D380del [cytosol]

BRAF V600E V47_M438del [cytosol]

V600E BRAF V169_D380del [cytosol]

p-S445,S729-BRAF [plasma membrane]

BRAF [cytosol]

p-S365,S445,S729 BRAF [cytosol]

hyperphosphorylated BRAF [plasma membrane]

p-S445,T599,S602,S729 BRAF [plasma membrane]

p-S445,S729-BRAF [cytosol]

p-S445,T599,S602,S729 BRAF [cytosol]

Modified Residues

Name

L-phenylalanine 595 replaced with L-leucine

Coordinate

595

PsiMod

L-phenylalanine removal [MOD:01644]

A protein modification that effectively removes or replaces an L-phenylalanine.

L-leucine residue [MOD:00020]

A protein modification that effectively converts a source amino acid residue to an L-leucine.

Name

O-phospho-L-serine at 445

Coordinate

445

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cardiofaciocutaneous syndrome	0060233	CFC syndrome, cardio-facial-cutaneous syndrome
LEOPARD syndrome	14291	Generalized lentiginosis, Multiple lentigines syndrome, Moynahan syndrome, Cardiocutaneous syndrome, Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome, Lentiginosis profusa syndrome, Gorlin syndrome II, Progressive cardiomyopathic lentiginosis
bladder carcinoma	4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
colorectal cancer	9256
Noonan syndrome	3490	Turner's phenotype, karyotype normal (disorder)

Cross References

RefSeq

NP_004324.2

ZINC - World Drugs

BRAF_HUMAN

ClinGen

CA295915, CA280071, CA280058

OpenTargets

ENSG00000157764

ZINC - FDA approved

BRAF_HUMAN

ZINC - Substances

BRAF_HUMAN

ZINC - Biogenic

BRAF_HUMAN

ZINC target

P15056

PRO

P15056

PDB

3SKC, 1UWJ, 4G9R, 6U2H, 5JRQ, 5HI2, 3TV4, 2L05, 5VAM, 6UAN, 5J2R, 4R5Y, 5VYK, 3PSB, 3TV6, 5VAL, 5VR3, 5CSW, 3NY5, 4XV1, 6B8U, 4E26, 5J18, 4YHT, 3PRF, 5FD2, 4G9C, 4WO5, 3PRI, 4KSP, 3C4C, 4MBJ, 1UWH, 4MNF, 4E4X, 4FK3, 6N0P, 4FC0, 6NSQ, 6U2G, 4JVG, 5ITA, 4KSQ, 3IDP, 3D4Q, 3II5, 5J17, 5C9C, 4DBN, 4XV3, 4RZW, 4XV2, 4RZV, 3PSD, 4CQE, 3Q4C, 5CSX, 5CT7, 4EHE, 3PPJ, 5JSM, 4XV9, 4EHG, 3PPK, 3OG7, 5HIE, 6CAD, 3Q96, 4H58, 4PP7, 4MNE, 5HID, 5JT2, 2FB8

ZINC - Investigational

BRAF_HUMAN

ZINC - Metabolites

BRAF_HUMAN

COSMIC

COSM468, COSM21612

GeneCards

P15056

ZINC - Predictions - Purchasable

BRAF_HUMAN

Orphanet

15376

HMDB Protein

HMDBP02597

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02750 MAP2K1	7	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.976	58
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.957	55
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.907	13
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.864	8
UniProt:P01112 HRAS	17	HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.783	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.763	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.758	5
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.758	5
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.744	4
UniProt:P36507 MAP2K2	5	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 [cytosol] (R-HSA-59504) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.744	7
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.609	2
UniProt:P01111 NRAS	19	NRAS [plasma membrane] (R-HSA-62725) NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662)	0.591	3
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.589	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.564	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.544	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q61097	5	KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y552 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y552 KSR1 [cytosol] (R-MMU-5672656)	0.499	3
UniProt:Q99N57	10	phospho-p-S338,Y340,Y341-RAF1 [cytosol] (R-MMU-5624465) RAF1 [cytosol] (R-MMU-167205) phospho-p-S338-RAF1 [cytosol] (R-MMU-5624469) phospho-p-S259,S621-RAF1 [cytosol] (R-MMU-109786) phospho-p-S621-RAF1 [plasma membrane] (R-MMU-206222) phospho-hyperphosphorylated RAF1 [plasma membrane] (R-MMU-5675193) phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5675420) phospho-p-S621-RAF1 [cytosol] (R-MMU-206028) phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5672665) phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-MMU-5672664)	0.499	3